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Ironwood Pharmaceuticals , Inc. Company Profile

16:22 EDT 21st June 2018 | BioPortfolio

IW-1973 and IW-1701 are investigational clinical compounds from Ironwood’s library of pharmacologically distinct soluble guanylate cyclase (sGC) stimulators. The stimulation of sGC is a clinically validated approach with broad therapeutic potential. Found throughout the body, sGC is an enzyme that is activated by the key regulator nitric oxide (NO) to increase levels of the second messenger cyclic guanosine monophosphate (cGMP), a signaling molecule that regulates blood flow, inflammation and fibrosis. As fundamental regulators of such core physiological processes, sGC stimulators may be relevant in the treatment of a broad range of diseases including cardiovascular diseases such as pulmonary arterial hypertension and congestive heart failure, as well as fibrotic diseases, muscular dystrophy, and other disorders. Ironwood established its expertise in the cGMP signaling pathway through the discovery and development of linaclotide, a guanylate cyclase C (GC-C) agonist that also modulates cGMP; the company has leveraged its GC-C expertise to discover its broad library of sGC stimulators.


News Articles [545 Associated News Articles listed on BioPortfolio]

Ironwood Pharmaceuticals to divide into two companies

US-based biotech company Ironwood Pharmaceuticals has revealed plans to split into two independent, publicly traded companies, Ironwood and R&D. After...Read More... The post Ironwood Pharmaceutic...

Ironwood Pharmaceuticals to Separate into Two Companies

Ironwood Pharmaceuticals will split into two independent companies, Ironwood and what is currently being dubbed R&D Co.

Critical Contrast: Ironwood Pharmaceuticals

Ironwood Pharmaceuticals and Infinity Pharmaceuticals are both medical companies, but which is the better business? We will contrast the two companies based on the strength of their valuation, risk, d...

Ironwood Pharma to Split in Two, Forming New Rare Disease Biz

Ironwood Pharmaceuticals (NASDAQ: IRWD) is making the unusual move of splitting up into two separate, publicly traded companies. One, which will keep the Ironwood name, will focus on selling its three...

Ironwood Pharmaceutical To Separate Into Two Independent Companies

NewsIronwood, a commercial biotech company, today announced that its Board of Directors has authorized an intent to separate into two independent, publicly traded companies (Ironwood and “R&D Co.”...

Allergan and Ironwood Settle Linzess Patent Suit With Sun Pharma

NewsWith the settlement, Ironwood and Allergan will grant the wholly owned subsidiaries of Sun Pharma a license to market a generic version of Linzess in the United States beginning on February 1, 203...

FDA gives orphan status to Ironwood's sickle cell disease drug

Ironwood Pharmaceuticals' IW-1701, or olinciguat, was given orphan drug designation by the FDA.  -More- 

Sun Pharma, Ironwood and Allergan settle Linzess patent litigation

Sun Pharmaceutical Industries’ wholly owned subsidiaries have reached an agreement with Ironwood Pharmaceuticals and Allergan to resolve the patent litigation...Read More... The post Sun Pharma, Iro...

PubMed Articles [134 Associated PubMed Articles listed on BioPortfolio]

Letter--Incorporating Real-World Evidence and Patient Value Criteria into Value-Based Frameworks for Relapsed/Refractory Multiple Myeloma.

Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Ja...

Genetics of familial hypercholesterolemia: a tool for development of novel lipid lowering pharmaceuticals?

Familial hypercholesterolemia is characterized by high LDL cholesterol and an elevated risk to develop coronary heart disease. Mutations in LDL receptor-mediated cholesterol uptake are the main cause ...

Post-production handling and administration of protein pharmaceuticals and potential instability issues.

The safety and efficacy of protein pharmaceuticals depend not only on biological activity, but also on purity levels. Impurities may be process related due to limitations in manufacturing, or product ...

Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential.

Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophophate (cGMP), transduces many of...

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines and Pharmaceuticals.

Methods to incorporate deuterium and tritium atoms into organic molecules are valuable for medicinal chemistry. The prevalence of pyridines and diazines in pharmaceuticals means that new ways to label...

Clinical Trials [216 Associated Clinical Trials listed on BioPortfolio]

Bioequivalence Study of Torrent Pharmaceuticals Ltd's Nebivolol 20 mg Tablet

Subjects to compare the single dose bioavailability of Torrent's Nebivolol Tablets 20 mg and Bystolic®20 mg Tablets of Forest Pharmaceuticals Inc., USA. Dosing periods of studies were sep...

Bioequivalence Study of Torrent Pharmaceuticals's Ltd's Nebivolol 20 mg Tablet

Subjects to compare the single dose bioavailability of Torrent's Nebivolol Tablets 20 mg and Bystolic 20 mg Tablets of Forest Pharmaceuticals Inc., USA. Dosing periods of studies were sepa...

Study Comparing Citalopram Hydrobromide Tablets 40 mg (Torrent Pharmaceuticals Ltd) and RLD Tablets 40 mg (Manufactured By Forest Pharmaceuticals Inc, Missouri) in 24+2 Normal Healthy Male Subjects in Fed Condition

- Objective: - The objective of this study is to compare the rate and extent of absorption of the Test Product, Citalopram Hydrobromide 40 mg (Torrent Pharmaceutical Li...

Bioequivalence Study of Torrent Pharmaceuticals Ltd.'s Rosuvastatin Calcium Tablets Under Fed Conditions

Subjects to compare the single dose bioavailability of Torrent's Rosuvastatin Calcium Tablets 40 mg and Crestor® 40 mg Tablets of AstraZeneca Pharmaceuticals LP, USA. Dosing periods of st...

Cilostazol 50 mg Tablets Under Fasting Conditions

This study will compare the relative bioavailability (rate and extent of absorption) of 50 mg Cilostazol Tablets manufactured by TEVA Pharmaceuticals Industries Ltd. and distributed by TEV...

Companies [1325 Associated Companies listed on BioPortfolio]

Almirall, S.A. and Ironwood Pharmaceuticals, Inc.

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agon...

Forest Laboratories, Inc. & Ironwood Pharmaceuticals, Inc.

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agon...

Ironwood Pharmaceuticals, Inc.

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agonist, is...

Ironwood Pharmaceuticals, Inc. and Almirall

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Ironwood is located in Cambridge, Mass. ...

Ironwood Pharmaceuticals, Inc. and AstraZeneca

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Ironwood is located in Cambridge, Mass. ...

More Information about "Ironwood Pharmaceuticals , Inc." on BioPortfolio

We have published hundreds of Ironwood Pharmaceuticals , Inc. news stories on BioPortfolio along with dozens of Ironwood Pharmaceuticals , Inc. Clinical Trials and PubMed Articles about Ironwood Pharmaceuticals , Inc. for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Ironwood Pharmaceuticals , Inc. Companies in our database. You can also find out about relevant Ironwood Pharmaceuticals , Inc. Drugs and Medications on this site too.

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