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Ironwood Pharmaceuticals , Inc. Company Profile

22:57 EST 11th December 2018 | BioPortfolio

IW-1973 and IW-1701 are investigational clinical compounds from Ironwood’s library of pharmacologically distinct soluble guanylate cyclase (sGC) stimulators. The stimulation of sGC is a clinically validated approach with broad therapeutic potential. Found throughout the body, sGC is an enzyme that is activated by the key regulator nitric oxide (NO) to increase levels of the second messenger cyclic guanosine monophosphate (cGMP), a signaling molecule that regulates blood flow, inflammation and fibrosis. As fundamental regulators of such core physiological processes, sGC stimulators may be relevant in the treatment of a broad range of diseases including cardiovascular diseases such as pulmonary arterial hypertension and congestive heart failure, as well as fibrotic diseases, muscular dystrophy, and other disorders. Ironwood established its expertise in the cGMP signaling pathway through the discovery and development of linaclotide, a guanylate cyclase C (GC-C) agonist that also modulates cGMP; the company has leveraged its GC-C expertise to discover its broad library of sGC stimulators.


News Articles [374 Associated News Articles listed on BioPortfolio]

Ironwood begins two Phase III trials of IW-3718

Ironwood Pharmaceuticals has commenced two Phase III clinical trials to examine the safety and efficacy of IW-3718 in patients with...Read More... The post Ironwood begins two Phase III trials of IW-3...

Ironwood returns US Zurampic rights to AstraZeneca, announces operational cuts

Ironwood Pharmaceuticals has revealed that it has taken the decision to hand the rights for gout therapy Zurampic (lesinurad) back to AstraZeneca, terminating an agreement between the two firms that w...

FDA fast-tracks Ironwood's heart failure candidate

Ironwood Pharmaceuticals' IW-1973, or praliciguat, indicated to treat patients with heart failure with preserved ejection fra -More- 

FDA gives orphan status to Ironwood's sickle cell disease drug

Ironwood Pharmaceuticals' IW-1701, or olinciguat, was given orphan drug designation by the FDA.  -More- 

Ironwood starts Phase IIIb trial of linaclotide for IBS-C

Ironwood Pharmaceuticals has commenced a Phase IIIb clinical trial to examine the efficacy and safety of linaclotide for the treatment...Read More... The post Ironwood starts Phase IIIb trial of linac...

Ironwood Pharmaceuticals starts Phase IIIb study of linaclotide in adult patients with IBS-C

Ironwood Pharmaceuticals has started a phase IIIb clinical trial evaluating the efficacy and safety of linaclotide 290 mcg on multiple abdominal symptoms in addition to pain, including bloating and di...

Ironwood Pharma Provides Q2 Financials, Terminates Deal with AstraZeneca

Ironwood Pharmaceuticals, located in Cambridge, Massachusetts, released its second-quarter financial report and updated its business activities. Key among the announcements was the termination of a li...

Ironwood Pharmaceuticals starts phase III program for IW-3718 in persistent gastroesophageal reflux disease

Ironwood Pharmaceuticals has initiated two Phase III clinical trials to assess the safety and efficacy of IW-3718 in patients with persistent gastroesophageal reflux disease (GERD).

PubMed Articles [133 Associated PubMed Articles listed on BioPortfolio]

Swimming activity in zebrafish larvae exposed to veterinary antiparasitic pharmaceuticals.

Veterinary antiparasitic pharmaceuticals have been detected in surface waters and several of these pharmaceuticals act on the nervous system on the target organisms implying that neurological effects ...

Chiral pharmaceuticals: Environment sources, potential human health impacts, remediation technologies and future perspective.

Chiral pharmaceuticals (CPs), including non-steroid anti-inflammatory drugs (NSAIDs), β-blockers and some herbicide and pesticides, are widely used in aquaculture, clinical treatment and many other f...

Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation.

The removal efficiency of pharmaceuticals in wastewater treatment plants (WWTPs) is variable and some of these compounds pass these plants almost intact and others presenting a removal efficiency clos...

Letter--Incorporating Real-World Evidence and Patient Value Criteria into Value-Based Frameworks for Relapsed/Refractory Multiple Myeloma.

Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Ja...

Effects of pharmaceuticals on microbial communities and activity of soil enzymes in mesocosm-scale constructed wetlands.

Cyperus alternifolius based mesocosm-scale constructed wetland was employed to remove pharmaceuticals. We investigated the microbial community composition using phosphor lipid fatty acids (PFLAs) anal...

Clinical Trials [228 Associated Clinical Trials listed on BioPortfolio]

Bioequivalence Study of Torrent Pharmaceuticals Ltd's Nebivolol 20 mg Tablet

Subjects to compare the single dose bioavailability of Torrent's Nebivolol Tablets 20 mg and Bystolic®20 mg Tablets of Forest Pharmaceuticals Inc., USA. Dosing periods of studies were sep...

Bioequivalence Study of Torrent Pharmaceuticals's Ltd's Nebivolol 20 mg Tablet

Subjects to compare the single dose bioavailability of Torrent's Nebivolol Tablets 20 mg and Bystolic 20 mg Tablets of Forest Pharmaceuticals Inc., USA. Dosing periods of studies were sepa...

Study Comparing Citalopram Hydrobromide Tablets 40 mg (Torrent Pharmaceuticals Ltd) and RLD Tablets 40 mg (Manufactured By Forest Pharmaceuticals Inc, Missouri) in 24+2 Normal Healthy Male Subjects in Fed Condition

- Objective: - The objective of this study is to compare the rate and extent of absorption of the Test Product, Citalopram Hydrobromide 40 mg (Torrent Pharmaceutical Li...

Bioequivalence Study of Torrent Pharmaceuticals Ltd.'s Rosuvastatin Calcium Tablets Under Fed Conditions

Subjects to compare the single dose bioavailability of Torrent's Rosuvastatin Calcium Tablets 40 mg and Crestor® 40 mg Tablets of AstraZeneca Pharmaceuticals LP, USA. Dosing periods of st...

Cilostazol 50 mg Tablets Under Fasting Conditions

This study will compare the relative bioavailability (rate and extent of absorption) of 50 mg Cilostazol Tablets manufactured by TEVA Pharmaceuticals Industries Ltd. and distributed by TEV...

Companies [1342 Associated Companies listed on BioPortfolio]

Almirall, S.A. and Ironwood Pharmaceuticals, Inc.

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agon...

Forest Laboratories, Inc. & Ironwood Pharmaceuticals, Inc.

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agon...

Ironwood Pharmaceuticals, Inc.

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agonist, is...

Ironwood Pharmaceuticals, Inc. and Almirall

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Ironwood is located in Cambridge, Mass. ...

Ironwood Pharmaceuticals, Inc. and AstraZeneca

Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Ironwood is located in Cambridge, Mass. ...

More Information about "Ironwood Pharmaceuticals , Inc." on BioPortfolio

We have published hundreds of Ironwood Pharmaceuticals , Inc. news stories on BioPortfolio along with dozens of Ironwood Pharmaceuticals , Inc. Clinical Trials and PubMed Articles about Ironwood Pharmaceuticals , Inc. for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Ironwood Pharmaceuticals , Inc. Companies in our database. You can also find out about relevant Ironwood Pharmaceuticals , Inc. Drugs and Medications on this site too.

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