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Telephus Medical LLC Company Profile

04:24 EDT 17th September 2019 | BioPortfolio

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host tissues, replicate and evade immune attack. These enzymes, are central components of the bacterial machinery staphylococci utilize to invade host tissues, evade the immune response and colonize surfaces of implanted medical devices found in some patients with severe infections. Originally identified as virulence factors, these enzymes, play critical roles in biofilm establishment and immune evasion by staphylococcal bacteria. Our initial development focus is the treatment of antibiotic-resistant periprosthetic joint infections – infections in patients who have received hip or knee replacements. Staphylococcal bacteria represent the vast majority of pathogens in these patients who suffer severe consequences from this type of infection. Diabetes, hyperglycemia and immunosuppressive medication use all are comorbidities which drive this infection rate, and the profound impact it has on mortality, morbidity and cost to the healthcare system. Telephus is dedicated to improving the lives of our patients by developing new therapeutics that harness the power of patients’ own immune systems to fight infection.


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Antibodies
An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be produc...

Rheumatology
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...

Joint Disorders
A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. Joints can be damaged by many types of injuries or diseases, including Arthritis - inflammation of a joint causes pain, stiffness, and swelling with ...


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