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Active Implants, LLC and TOCA Company Profile

07:18 EDT 18th September 2019 | BioPortfolio

Active Implants, LLC develops orthopedic implant solutions that complement the natural biomechanics of the musculoskeletal system, allowing patients to maintain or return to an active lifestyle. Active Implants is privately held with headquarters in Memphis, Tennessee. European offices are in Driebergen, The Netherlands, with R&D facilities in Netanya, Israel. For more information, visit www.activeimplants.com.


News Articles [632 Associated News Articles listed on BioPortfolio]

TOCA 511 and Toca FC Treatment Misses OS Endpoint in Glioma Trial

Treatment with Toca 511 and Toca FC did not improve overall survival compared with standard therapy in patients with recurrent high-grade glioma undergoing resection, missing the primary endpoint of t...

Tocagen’s Toca 5 Phase 3 Trial Misses Primary Endpoint in Patients with Recurrent High Grade Glioma

SAN DIEGO, Sept. 12, 2019 /PRNewswire/ — Tocagen Inc. (Nasdaq: TOCA), a clinical-stage, cancer-selective gene therapy company, today announced that the Toca 5 Phase 3, randomized, multi-center c...

Tocagen plummets on phase 3 data for glioma therapy

A phase 3 trial of Tocagen’s therapy for high-grade glioma (HGG) – a form of brain cancer – failed to show an improvement in overall survival, sending the biotech’s shares into freefall. The T...

Toca 511 & Toca FC in Recurrent High-Grade Glioma

Pivotal clinical trial fails to confirm benefit of 511 & Toca FC in recurrent High-Grade Glioma.

EU awards Active Implants a grant of around $6.8M

The European Union has granted Active Implants a Horizon 2020 grant of approximately $6.8 million for use in developing a men -More- 

Tocagen's late-stage study of Toca 511, Toca FC immunotherapy in high-grade glioma fails main goal https://www.firstwordpharma.com/node/1665744  $TOCA

Tocagen's late-stage study of Toca 511, Toca FC immunotherapy in high-grade glioma fails main goal https://www.firstwordpharma.com/node/1665744  $TOCA

Toca 511 & Toca FC Produce Durable Responses in Recurrent High-Grade Glioma

Toca 511 & Toca FC Produce Durable Responses in Recurrent High-Grade Glioma.

Tocagen On The Rocks With Phase III Brain Cancer Study Failure

The firm’s stock crashed on news that its Toca 511/Toca FC regimen did not show an overall survival benefit or...    

PubMed Articles [1240 Associated PubMed Articles listed on BioPortfolio]

Immediate Placement of Trabecular Implants in Sites of Failed Implants.

Immediate replacement of a new implant for a failed implant has the benefit of reducing treatment time and increasing patient satisfaction. Limited studies have reported the outcome of implants placed...

Can implants move in bone? A longitudinal in-vivo micro CT analysis of implants under constant forces in rat vertebrae.

Whereas stationary stability of implants has been postulated for decades, recent studies suggested a phenomenon termed implant migration. This describes a change in position of implants as a reaction ...

Outcomes after Application of Active Bone Conducting Implants.

A bone conducting implant is a treatment option for individuals with conductive or mixed hearing loss (CHL, MHL) who do not tolerate regular hearing aids, and for individuals with single-sided deafnes...

Mandibular Angle Implants.

After studying this article, the reader should be able to understand the two basic types of implants for aesthetic augmentation of the jaw angles and the aesthetic goals in using them. The operative s...

Anatomic Implants in Breast Reconstruction: A Comparison of Outcomes and Aesthetic Results Compared to Smooth Round Silicone Implants.

Direct comparison studies of outcomes and aesthetic satisfaction of anatomic implants compared to other implants are scarce in the literature.

Clinical Trials [3527 Associated Clinical Trials listed on BioPortfolio]

A Study of the Safety of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Subjects With Newly Diagnosed High Grade Glioma Receiving Standard of Care

This is a multi-center, open label trial of combination therapy with Toca 511 and ascending doses of Toca FC added to the SOC for newly diagnosed HGG.

A Study of Toca 511 & Toca FC in Patients With Recurrent High Grade Non-Muscle Invasive Bladder Cancer (Toca 8)

This is a Phase 1, multicenter, open-label study of intravesical Toca 511 followed by oral Toca FC in patients with high grade (HG) non-muscle invasive bladder cancer (NMIBC), with cohort ...

A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Subjects With Solid Tumors

This is a multicenter, open label, single arm study of Toca 511 and Toca FC. Based on their cancer diagnosis (brain metastases from non small cell lung cancer or breast cancer; colorectal ...

Study of a Retroviral Replicating Vector to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor

This is a multicenter study evaluating the safety and tolerability of increasing doses of Toca 511, a retroviral replicating vector, injected into the resection cavity of subjects with Gra...

Multicentre Phase III Erythropoietic Protoporphyria Study

This was a phase III, multicentre, randomised, double-blind, placebo-controlled study, to evaluate the safety and efficacy of subcutaneous bioresorbable afamelanotide implants in patients ...

Companies [1014 Associated Companies listed on BioPortfolio]

Active Implants, LLC and TOCA

Active Implants, LLC develops orthopedic implant solutions that complement the natural biomechanics of the musculoskeletal system, allowing patients to maintain or return to an ac...

Active Implants, LLC

Active Implants, LLC develops orthopedic implant solutions that complement the natural biomechanics of the musculoskeletal system, allowing patients to maintain or return to an ac...

Active Implants Corporation

Active Implants LLC develops orthopedic implant solutions that complement the natural biomechanics of the musculoskeletal system, allowing patients to maintain or return to an act...

Active Implants LLC

Active Implants LLC develops orthopedic implant solutions that complement the natural biomechanics of the musculoskeletal system, allowing patients to maintain or return to an act...

Active Implants Corporation (AIC)

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Arthroplasty Joint Disorders Orthopedics Spinal Cord Disorders Orthopedics is the science or practice of correcting deformities caused by disease or damage to the bones and joints of the skeleton. This specialized branch of surgery may ...


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