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MEBIAS Discovery LLC Company Profile

07:57 EDT 23rd April 2018 | BioPortfolio

MEBIAS, an emerging leader in the field of biased agonism GPCR drug discovery, was founded by three highly experienced drug discovery scientists, formerly of Merck and Johnson & Johnson. MEBIAS has developed a platform to discover next-generation GPCR drugs that avoid the on-target side effects of earlier generations of compounds, which historically signal through both the G-protein as well as the beta-arrestin pathways. The platform is established on the principle that compounds signaling through either the G-protein or the beta-arrestin pathway can be efficacious with fewer or no side effects. At the core of MEBIAS’ know-how are two specialized technologies: native GPCR purification and protein nuclear magnetic resonance. This know-how allows MEBIAS to achieve sensitivity unmatched by cell assays alone. The Company’s lead program has produced proprietary mu opioid agonists designed to achieve analgesia without respiratory depression, constipation, and addiction potential seen in opioids on the market today. An additional internal discovery program will be initiated by the end of 2017. Areas of focus are neuroscience/pain, metabolic, gastroparesis, and inflammatory disorders.


News Articles [283 Associated News Articles listed on BioPortfolio]

Blue Oak and PsychoGenics partner on drug discovery

Blue Oak Pharmaceuticals and PGI Drug Discovery have entered into a partnership to discover and optimize novel treatments for brain disorders and psychiatric conditions. Under the terms of the agreeme...

How Robot Math and Smartphones Led Researchers to a Drug Discovery Breakthrough

NewsResearchers have figured out how to apply an algorithm originally designed to help robots move to an entirely different problem: drug discovery.

Beacon Discovery, Janssen team up in metabolic conditions

Beacon Discovery Inc. and Janssen Pharmaceuticals Inc. are teaming up in the discovery of small molecules aimed at various G-protein coupled receptor (GPCR) targets for metabolic diseases.

X-Chem, AstraZeneca expand drug discovery partnership

X-Chem, a small molecule discovery specialist, has expanded its existing global drug discovery and technology transfer collaboration with AstraZeneca.

Beacon enters drug discovery collaboration with Janssen

US-based drug discovery firm Beacon Discovery has entered a multi-year collaboration agreement with Janssen Pharmaceuticals for small molecule compounds to...Read More... The post Beacon enters drug d...

Bayer and PeptiDream enter into multi-target discovery collaboration

In a discovery and license collaboration valued up to $1.1bn, Japanese pharma PeptiDream Inc. will use its Peptide Discovery Platform System (PDPS) technology to identify macrocyclic/constrained pepti...

Disrupting Drug Discovery: How GSK is Using Data More Effectively in R&D to Drive Innovation

ArticleDrug Discovery & Development spoke with Mark Ramsey, Ph.D., chief data office at GSK, in an exclusive interview about the company’s new analytics initiatives to manage R&D data and quickly br...

ChemDiv discovery platform tapped to advance R&D pipeline into preclinical studies

The Tri-Institutional Therapeutics Discovery Institute, Inc. will use ChemDiv's proprietary discovery chemistry platform to advance its research and development (R&D) pipeline.

PubMed Articles [514 Associated PubMed Articles listed on BioPortfolio]

Protac-induced Protein Degradation in Drug Discovery: Breaking the Rules - or Just Making New Ones?

Targeted protein degradation, using bifunctional small molecules (Protacs) to remove specific proteins from within cells, has emerged as a novel drug discovery strategy with the potential to offer the...

From machine learning to deep learning: progress in machine intelligence for rational drug discovery.

Machine intelligence, which is normally presented as artificial intelligence, refers to the intelligence exhibited by computers. In the history of rational drug discovery, various machine intelligence...

Allosteric Tuning of Caspase-7: a Fragment-Based Drug Discovery Approach.

The caspase family of cysteine proteases are highly sought after drug targets due to their essential roles in apoptosis, proliferation and inflammation pathways. High throughput screening efforts to d...

Challenges with modelling anxiety disorders: a possible hindrance for drug discovery.

Discovery of the Second Messenger Cyclic di-GMP.

The nearly ubiquitous bacterial second messenger cyclic di-GMP is involved in a multitude of fundamental physiological processes such as sessility/motility transition and the switch between the acute ...

Clinical Trials [164 Associated Clinical Trials listed on BioPortfolio]

Discovery Elbow Multi-Center Prospective Study

The purpose of this prospective clinical trial is to document the performance and clinical outcomes of Biomet Discovery Elbow.

A Clinical Investigation of the Discovery™ Elbow System

The purpose of this study is to perform a five-year, multi-center prospective evaluation of the Discovery™ Elbow System for outcome and durability. Relief of pain and restoration of fun...

Endometriosis Biomarker Discovery Study

This is a prospective, Single time point, discovery study intending to identify biomarkers that can differentiate endometriosis from other underlying reasons for pelvic pain. Patients unde...

Protein Biomarker Discovery and Validation in Chronic Obstructive Pulmonary Disease (COPD) And Asthma

The purpose of the study is to better understand the function of asthma and COPD, and response to therapy. There are two Phases to this study broken into two arms. In Phase I, our propose ...

Biologic Basis of Liver Cancer From Chronic Hepatitis B

The focus of the study is to identify viral factors and host immune responses that differentiate HBV-related HCC patients from HBV patients who have not progressed to HCC. To that end, the...

Companies [1085 Associated Companies listed on BioPortfolio]

MEBIAS Discovery LLC

MEBIAS, an emerging leader in the field of biased agonism GPCR drug discovery, was founded by three highly experienced drug discovery scientists, formerly of Merck and Johnson & J...

Discovery Health

Discovery Health Media includes the Discovery Health and FitTV television networks and online assets, including www.discoveryhealth.com, as well as its Continuing Medical Education (CME) business and ...

Argenta Discovery Ltd.

Argenta Discovery is a privately held drug discovery company, applying its integrated medicinal chemistry, biology, ADMET and CADD expertise to drive drug discovery programmes. Argenta has a successfu...

Pyxis Discovery B.V.

The ambition of Pyxis Discovery is to be the preferred chemistry service provider for companies that are active in small molecule drug discovery. Pyxis Discovery's Smart approach of designing and ...

Med Discovery SA

Med Discovery’s mission is the discovery and development of highly specific protein drugs to treat uro-genital cancers. By combining biological drug discovery expertise with a strong in-house knowle...

More Information about "MEBIAS Discovery LLC" on BioPortfolio

We have published hundreds of MEBIAS Discovery LLC news stories on BioPortfolio along with dozens of MEBIAS Discovery LLC Clinical Trials and PubMed Articles about MEBIAS Discovery LLC for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of MEBIAS Discovery LLC Companies in our database. You can also find out about relevant MEBIAS Discovery LLC Drugs and Medications on this site too.

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