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MEBIAS Discovery LLC Company Profile

07:33 EST 19th December 2018 | BioPortfolio

MEBIAS, an emerging leader in the field of biased agonism GPCR drug discovery, was founded by three highly experienced drug discovery scientists, formerly of Merck and Johnson & Johnson. MEBIAS has developed a platform to discover next-generation GPCR drugs that avoid the on-target side effects of earlier generations of compounds, which historically signal through both the G-protein as well as the beta-arrestin pathways. The platform is established on the principle that compounds signaling through either the G-protein or the beta-arrestin pathway can be efficacious with fewer or no side effects. At the core of MEBIAS’ know-how are two specialized technologies: native GPCR purification and protein nuclear magnetic resonance. This know-how allows MEBIAS to achieve sensitivity unmatched by cell assays alone. The Company’s lead program has produced proprietary mu opioid agonists designed to achieve analgesia without respiratory depression, constipation, and addiction potential seen in opioids on the market today. An additional internal discovery program will be initiated by the end of 2017. Areas of focus are neuroscience/pain, metabolic, gastroparesis, and inflammatory disorders.


News Articles [335 Associated News Articles listed on BioPortfolio]

MEBIAS Discovery Receives Grant from NIDA to Advance Its Signaling-Pathway Selective Mu-Opioid Receptor Drug Candidate

Preclinical studies of lead molecules have shown absence of respiratory depression, rewarding behavior, sedation, and constipation associated with traditional opioids M...

MEBIAS Discovery Receives Grant from NIDA to Advance Its Signaling-Pathway Selective Mu-Opioid ...

Preclinical studies of lead molecules have shown absence of respiratory depression, rewarding behavior, sedation, and constipation associated with traditional opioids Read more...

C4X Discovery launches drug discovery partnership with LifeArc

C4X Discovery has formed a discovery partnership with British medical research charity LifeArc to collaborate on the development of small...Read More... The post C4X Discovery launches drug discovery ...

Magnetic Resonance Mass Spectrometry for Fragment Based Drug Discovery

ArticleHigh throughput screening (HTS) has been the go-to technique for early-stage drug discovery for many years. Contributed Au

Integrated lead discovery: An evolving toolbox

(SLAS (Society for Laboratory Automation and Screening)) A new SLAS Discovery review article by GlaxoSmithKline researchers in the US and UK offers an informative guide to the established and emerging...

High-Throughput Flow Cytometry in Drug Discovery

NewsA new special issue of SLAS Discovery reflects examples of the recent groundswell of creative new applications for high-throughput flow cytometry (HTFC) in drug discovery.

Sygnature Discovery Announces Multi-Target Drug Discovery Deal with Sitryx Therapeutics

Sygnature Discovery, a leading independent integrated drug discovery and pre-clinical services company, has today announced a multi-target, integrated drug discovery collaboration with Sitryx Therapeu...

C4XD forms discovery partnership with AI company GTN

C4X Discovery has entered into a drug discovery partnership with artificial intelligence (AI) company GTN.

PubMed Articles [459 Associated PubMed Articles listed on BioPortfolio]

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources.

Following multiple warnings from governments and health organisations, there has been renewed investment, led by the public sector, in the discovery of novel antimicrobials to meet the challenge of ri...

Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory.

The identification of high-quality starting points for drug discovery is an enduring challenge in medicinal chemistry. Yet, the chemical space explored in discovery programmes tends be limited by the ...

Considerations for implementing an informatics system to support biologics drug discovery.

A comprehensive, well-functioning and scientifically aware informatics environment is of the utmost importance in supporting effective drug discovery programs. However, implementing such a system can,...

The continuing effect of the discovery of IgE by Kimishige Ishizaka.

Sadly, Kimi Ishizaka died on July 6, 2018. I would like to take the opportunity to consider his role in the discovery of IgE and the effect of that discovery. All of us owe an enormous debt to those w...

Filling the drug discovery gap: is high-content screening the missing link?

In recent years, questions about the sustainability of the current drug discovery process have triggered a revival of interest in phenotypic drug discovery approaches. This trend has clearly been ampl...

Clinical Trials [189 Associated Clinical Trials listed on BioPortfolio]

Discovery Elbow Multi-Center Prospective Study

The purpose of this prospective clinical trial is to document the performance and clinical outcomes of Biomet Discovery Elbow.

A Clinical Investigation of the Discovery™ Elbow System

The purpose of this study is to perform a five-year, multi-center prospective evaluation of the Discovery™ Elbow System for outcome and durability. Relief of pain and restoration of fun...

Using 'Guided-Discovery-Learning' to Optimize and Maximize Transfer of Surgical Simulation

The study is a randomized experimental study comparing two forms of learning; guided-discovery-learning and traditional instructional learning. Recruiting sixty-four participants, the inve...

Endometriosis Biomarker Discovery Study

This is a prospective, Single time point, discovery study intending to identify biomarkers that can differentiate endometriosis from other underlying reasons for pelvic pain. Patients unde...

Protein Biomarker Discovery and Validation in Chronic Obstructive Pulmonary Disease (COPD) And Asthma

The purpose of the study is to better understand the function of asthma and COPD, and response to therapy. There are two Phases to this study broken into two arms. In Phase I, our propose ...

Companies [1111 Associated Companies listed on BioPortfolio]

MEBIAS Discovery LLC

MEBIAS, an emerging leader in the field of biased agonism GPCR drug discovery, was founded by three highly experienced drug discovery scientists, formerly of Merck and Johnson & J...

Discovery Health

Discovery Health Media includes the Discovery Health and FitTV television networks and online assets, including www.discoveryhealth.com, as well as its Continuing Medical Education (CME) business and ...

Argenta Discovery Ltd.

Argenta Discovery is a privately held drug discovery company, applying its integrated medicinal chemistry, biology, ADMET and CADD expertise to drive drug discovery programmes. Argenta has a successfu...

Pyxis Discovery B.V.

The ambition of Pyxis Discovery is to be the preferred chemistry service provider for companies that are active in small molecule drug discovery. Pyxis Discovery's Smart approach of designing and ...

Med Discovery SA

Med Discovery’s mission is the discovery and development of highly specific protein drugs to treat uro-genital cancers. By combining biological drug discovery expertise with a strong in-house knowle...

More Information about "MEBIAS Discovery LLC" on BioPortfolio

We have published hundreds of MEBIAS Discovery LLC news stories on BioPortfolio along with dozens of MEBIAS Discovery LLC Clinical Trials and PubMed Articles about MEBIAS Discovery LLC for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of MEBIAS Discovery LLC Companies in our database. You can also find out about relevant MEBIAS Discovery LLC Drugs and Medications on this site too.

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