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MEBIAS Discovery LLC Company Profile

11:45 EST 27th January 2020 | BioPortfolio

MEBIAS, an emerging leader in the field of biased agonism GPCR drug discovery, was founded by three highly experienced drug discovery scientists, formerly of Merck and Johnson & Johnson. MEBIAS has developed a platform to discover next-generation GPCR drugs that avoid the on-target side effects of earlier generations of compounds, which historically signal through both the G-protein as well as the beta-arrestin pathways. The platform is established on the principle that compounds signaling through either the G-protein or the beta-arrestin pathway can be efficacious with fewer or no side effects. At the core of MEBIAS’ know-how are two specialized technologies: native GPCR purification and protein nuclear magnetic resonance. This know-how allows MEBIAS to achieve sensitivity unmatched by cell assays alone. The Company’s lead program has produced proprietary mu opioid agonists designed to achieve analgesia without respiratory depression, constipation, and addiction potential seen in opioids on the market today. An additional internal discovery program will be initiated by the end of 2017. Areas of focus are neuroscience/pain, metabolic, gastroparesis, and inflammatory disorders.


News Articles [333 Associated News Articles listed on BioPortfolio]

PhoreMost and C4X Discovery Announce Neurodegeneration Focused Drug Discovery Collaboration

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, and C4X Discovery Holdings plc, a pioneering drug discovery company, have ann...

PhoreMost, C4X Discovery announce neurodegeneration collaboration

The collaboration will initially accelerate C4X Discovery’s Parkinson’s disease drug discovery pipeline.

AI in Drug Discovery Conference 2020

16 - 17 March 2020, London, UK. SMi group presents the launch of the inaugural AI in Drug Discovery conference taking place in London. AI-empowered machine learning technologies hold the potential of...

Automated Discovery

To what extent can scientific discovery be automated? Where are the areas where automation can make the biggest contribution to human efforts? These questions and a number of others are addressed in a...

Scottish CRO Integrates Drug Discovery and Compound Management

At the BioCity Scotland incubator, BioAscent Discovery uses former Merck Sharp & Dohme facilities and works with the European Lead Factory’s platform to support a cross-functional environment f...

Sygnature Discovery invests in high-throughput screening capability

Sygnature Discovery has added in-house high-throughput screening (HTS) to its range of drug discovery services. This is backed up by its new Leadfinder compound library. HTS allows many thousands of m...

Bayer and Exscientia Collaborate to Leverage the Potential of Artificial Intelligence in Cardiovascular and Oncology Drug Discovery

Bayer and Exscientia Ltd., a UK-based Artificial Intelligence (AI)-driven drug discovery company, have entered into a three-year, multi-target collaboration. The partners will work on early research p...

Pharmacophore modeling and applications in drug discovery: challenges and recent advances

The most downloaded article from Drug Discovery Today in Q2 2010 was by Sheng-Yong Yang and deals with the application of pharmacophore modeling to drug discovery.

Drugs and Medications [0 Results]

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PubMed Articles [393 Associated PubMed Articles listed on BioPortfolio]

Fragment-based drug discovery using cryo-EMs.

Recent advances in cryo-electron microscopy (EM) structure determination have pushed the resolutions obtainable by the method into the range widely considered to be of utility for drug discovery. Here...

Collection and Analysis of Multimodal Data for SUDEP Biomarker Discovery.

This paper discusses the acquisition and processing of multimodal physiological data from patients with epilepsy in Epilepsy Monitoring Units for the discovery of risk factors for Sudden Expected Deat...

Mendelian Gene Discovery: Fast and Furious with No End in Sight.

Gene discovery for Mendelian conditions (MCs) offers a direct path to understanding genome function. Approaches based on next-generation sequencing applied at scale have dramatically accelerated gene ...

An overview of late-stage functionalization in today's drug discovery.

: Late-stage functionalization (LSF) can introduce important chemical groups in the very last steps of the synthesis. LSF has the potential to speed up the preparation of novel chemical entities and d...

Antibiotics: past, present and future.

The first antibiotic, salvarsan, was deployed in 1910. In just over 100 years antibiotics have drastically changed modern medicine and extended the average human lifespan by 23 years. The discovery of...

Clinical Trials [237 Associated Clinical Trials listed on BioPortfolio]

Discovery Elbow Multi-Center Prospective Study

The purpose of this prospective clinical trial is to document the performance and clinical outcomes of Biomet Discovery Elbow.

PCD New Gene Discovery

This is a new gene discovery program for individuals with PCD who do not have a specific genetic etiology identified. Research procedures involve a single blood draw from the affected indi...

A Clinical Investigation of the Discovery™ Elbow System

The purpose of this study is to perform a five-year, multi-center prospective evaluation of the Discovery™ Elbow System for outcome and durability. Relief of pain and restoration of fun...

Using 'Guided-Discovery-Learning' to Optimize and Maximize Transfer of Surgical Simulation

The study is a randomized experimental study comparing two forms of learning; guided-discovery-learning and traditional instructional learning. Recruiting sixty-four participants, the inve...

Endometriosis Biomarker Discovery Study

This is a prospective, Single time point, discovery study intending to identify biomarkers that can differentiate endometriosis from other underlying reasons for pelvic pain. Patients unde...

Companies [1173 Associated Companies listed on BioPortfolio]

MEBIAS Discovery LLC

MEBIAS, an emerging leader in the field of biased agonism GPCR drug discovery, was founded by three highly experienced drug discovery scientists, formerly of Merck and Johnson & J...

Discovery Health

Discovery Health Media includes the Discovery Health and FitTV television networks and online assets, including www.discoveryhealth.com, as well as its Continuing Medical Education (CME) business and ...

Argenta Discovery Ltd.

Argenta Discovery is a privately held drug discovery company, applying its integrated medicinal chemistry, biology, ADMET and CADD expertise to drive drug discovery programmes. Argenta has a successfu...

Pyxis Discovery B.V.

The ambition of Pyxis Discovery is to be the preferred chemistry service provider for companies that are active in small molecule drug discovery. Pyxis Discovery's Smart approach of designing and ...

Med Discovery SA

Med Discovery’s mission is the discovery and development of highly specific protein drugs to treat uro-genital cancers. By combining biological drug discovery expertise with a strong in-house knowle...

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We have published hundreds of MEBIAS Discovery LLC news stories on BioPortfolio along with dozens of MEBIAS Discovery LLC Clinical Trials and PubMed Articles about MEBIAS Discovery LLC for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of MEBIAS Discovery LLC Companies in our database. You can also find out about relevant MEBIAS Discovery LLC Drugs and Medications on this site too.

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