Oncothyreon Inc. Company Profile

12:48 EST 21st November 2017 | BioPortfolio

Oncothyreon is a biotechnology company dedicated to the development of oncology products that can improve the lives and outcomes of cancer patients. We are currently developing multiple therapeutic candidates designed to target cancer in specific and effective ways. Our pipeline includes both synthetic vaccines and small molecules for a variety of cancer indications.
Oncothyreon is headquartered in Seattle, Washington. The Company is traded on the NASDAQ National Market under the symbol ONTY.

Small molecule pipeline:

PX-866 Targets the Phosphatidylinositol-3-kinase (PI-3K) Pathway

PX-866 is a small molecule drug that irreversibly inhibits phosphatidylinositol-3-kinase (PI-3K), a family of intracellular signaling molecules that play essential roles in multiple cellular functions. In normal cells the PI-3K pathway is tightly controlled, whereas the inappropriate activation of PI-3K is important in the pathogenesis of multiple human cancers, making it a rational and attractive target for drug development.


ONT-701 is a pan-inhibitor of the B-cell lymphoma-2, or Bcl-2, family of anti-apoptotic proteins. Overexpression of one or more members of the Bcl-2 family of proteins is common in most human cancers.

ONT-701 and related compounds were obtained through an exclusive licensing agreement with the Sanford-Burnham Medical Research Institute. ONT-710 is currently in preclinical development.



L-BLP25 (formerly Stimuvax®) is a therapeutic vaccine designed to stimulate an individual's immune system to recognize cancer cells and control the growth and spread of cancers in order to increase the survival of cancer patients. L-BLP25 incorporates a 25-amino acid sequence of the cancer-associated marker MUC-1 in a liposomal formulation. The vaccine is thought to work by stimulating a T-cell mediated immune response to cancer cells expressing the target MUC-1.



2601 Fourth Avenue
Suite 500
WA 98121


Phone: (206) 801-2100
Fax: (206) 801-2101

News Articles [1 Associated News Articles listed on BioPortfolio]

License Agreement: Array BioPharma, $ARRY (Oncothyreon, $ONTY)

May 2013 Array BioPharma (ARRY) entered into a Development and Commercialization Agreement with Oncothyreon (ONTY) to collaborate on development and commercialization of ONT380 for the treatment of ca...

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Companies [2 Associated Companies listed on BioPortfolio]

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