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AndroScience Corporation Company Profile

15:00 EDT 26th March 2019 | BioPortfolio

Founded in 2000, AndroScience Corporation (ASC) is developing two novel small molecule platforms based on the therapeutic targets of the androgen receptor (AR) and select members of the Signal Transducer and Activator of Transcription (STAT) signaling pathway. The first patented family of compounds function through the enhancing degradation of AR protein, a novel mechanism of action described as AR degradation enhancers (ARD enhancers). This pipeline of drug candidates for the androgen-related disorders includes clinical stage dermal programs in acne and alopecia and preclinical programs in prostate cancer, liver cancer and bladder cancer; as well as spinal bulbar muscular atrophy (Kennedy's Disease). The second major drug development program is based on a family of novel small molecules that function as STAT 3 and 5 transcription factors' inhibitor. Initiated in 2009, preclinical proof of concept data (both in vitro and in vivo) has been obtained and efforts are underway to develop lead drug candidates in the oncology setting for breast cancer, pancreatic cancer, colon cancer, glioblastoma, and other metastatic disease. Additional applications in treating immune mediated disorders are also under development using STAT 3 and 5 inhibitor drug candidates.


News Articles [110 Associated News Articles listed on BioPortfolio]

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Orion Corporation: Managers' transactions - Christer Nordstedt

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Orion Corporation: Managers' transactions - Timo Lappalainen

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ORION CORPORATION      STOCK EXCHANGE RELEASE   1 MARCH 2019   at 19.10 EET             Orion Corporation: Transfer of 47,279 own B shares on 1 Ma...

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Companies [183 Associated Companies listed on BioPortfolio]

AndroScience Corp.

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