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Dermatitis Research

05:37 EDT 23rd May 2018 | BioPortfolio

Detection of IL-36y via non-invasive tape stripping reliably discriminates psoriasis from atopic eczema.

This report demonstrates that sampling and detection of IL-36γ protein by non-invasive tape stripping of skin lesion provides a highly sensitive and selective diagnostic for psoriatic inflammation.

Assessment of Likelihood Ratio for Four Contact Dermatitis Symptoms of Vinca Minor.

 Contact dermatitis (CD) is a frequently occurring medical condition, for which (VM) is one of the recommended homeopathic medicines. However, the symptoms indicating this medicine have not yet been assessed systematically. Likelihood ratio (LR), based on Bayesian statistics, may yield better estimation of a medicine's indication than the existing method of entry of symptoms into materia medica...

Metal hypersensitivity in the context of connective tissue disease - An opportunity for practice prevention.

Metal hypersensitivity reactions (MHR) are not associated with metal containing orthodontic implants unless there is a positive history of dermatitis from a high nickel-release item (piercing post, earring, watch). We wish to present this letter to highlight evidence surrounding orthodontic-related nickel hypersensitivity and to bring to the readers attention current American Contact Dermatitis So...

A systematic review on the off-label use of montelukast in atopic dermatitis treatment.

Background Atopic dermatitis (AD) is the most common form of eczema. As leukotriene mediators are involved in the inflammatory phase of atopic dermatitis, montelukast has been suggested as a possible therapy. Aim of the review To evaluate the safety and efficacy of montelukast off-label use for the treatment atopic dermatitis. Method A search was performed from database inception until March 20...

A Review of Fabry Disease.

The class of medications known as Janus kinase inhibitors block cytokine-mediated signaling via the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, which plays an important role in immunoregulation and normal cell growth. This class includes the drugs tofacitinib, approved for the treatment of rheumatoid arthritis, and ruxolitinib, approved for the treatment of my...

Sensitisation to outdoor and indoor fungi in atopic dermatitis patients and the relation to the occurrence of food allergy to peanuts and walnuts.

The aim of this study is the evaluation of the relation between the sensitisation to outdoor and indoor fungi and allergy to peanuts and walnuts in atopic dermatitis patients aged 14 years and older. The complete dermatological and allergological examinations were perfomed in all included patients; the occurrence of food allergy to peanuts and walnuts was recorded (specific IgE, skin prick test, h...

Wet-wrap therapy with halometasone cream for severe adult atopic dermatitis.

Currently there is no cure for severe atopic dermatitis (AD). Wet-wrap therapy (WWT) has also been used to treat pediatric AD and shown a satisfactory effectiveness, but clinical evidence supporting the use of WWT on severe adult AD is still insufficient.

Pet keeping in childhood and asthma and allergy among children in Tianjin area, China.

This study aims to find out the relationship between pet keeping in childhood and asthma and allergy among children aged 0-8 years old in Tianjin, China. Parental or guardians reports of 7360 children were analyzed. 1490 (21.6%) families kept pets at the time of the survey (current), among them 4.0% cats, and 14.7% dogs. For the first year of life of children (early), 1196 (18.4%) families kept pe...

Sonographic visualization of nipple blood flow can help differentiate Paget disease from benign eczematous nipple lesions.

Paget disease of the breast is a rare cancer that originates from the nipple-areolar complex. It is often overlooked and misdiagnosed as benign chronic eczema of the nipple. We aimed to retrospectively verify whether blood flow analysis using Doppler sonography was useful for detecting the presence of Paget disease.

Molar-Incisor Hypomineralization: Positive Correlation with Atopic Dermatitis and Food Allergies.

Molar-incisor hypomineralization is a disturbance in dental development that involves first permanent molars as well as permanent incisors with a prevalence that ranges from 2.5% to 40%. The objective of this study was to investigate the etiology of molar-incisor hypomineralization among school children from two randomly selected towns in the province of Barcelona, Spain.

Measurement of Health Care Quality in Atopic Dermatitis - Development and Application of a Set of Quality Indicators.

Quality indicators are essential tools for the assessment of health care, in particular for guideline-based procedures.

Damage control: Differentiating incontinence-associated dermatitis from pressure injury.

The Unique Molecular Signatures of Contact Dermatitis and Implications for Treatment.

Irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) are common skin disorders that are characterized by inflammation, oozing, crusting, and pruritus. Atopic dermatitis (AD) is an inflammatory skin disease characterized by immune and barrier abnormalities and is additionally a risk factor for acquiring ICD and ACD. New work on allergic sensitization to common allergens (e.g., ni...

Adverse Effects of Azathioprine in a Child and Her Mother with Eczema.

A retrospective study of dermatitis herpetiformis from an immunobullous disease clinic in north India.

Indian data on dermatitis herpetiformis (DH) is not available. The aim of this study was to investigate the demographic and clinicopathological characteristics of patients with DH and to study its association with other autoimmune diseases.

Nemolizumab in moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study.

Nemolizumab, an anti-interleukin-31 receptor A monoclonal antibody, improved pruritus, dermatitis, and sleep in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments in a phase II, 12-week, randomized, double-blind, placebo-controlled study (Part A) (NCT01986933).

The ins and outs of an 'outside-in' view of allergies: atopic dermatitis and allergy prevention.

The skin barrier is a dynamic innate immune organ. This review summarizes the current understanding of how deficiencies associated with atopic dermatitis invite other atopic disorders of the allergic march.

ADAM17 deficient mice model the transcriptional signature of human atopic dermatitis.

Laxative-Induced Contact Dermatitis.

A 5-year-old female with Charcot-Marie-Tooth neuropathy and a history of constipation presented to the emergency department with a new blistering buttocks rash, which was initially concerning for nonaccidental burn. Upon further investigation, it was found that Ex-Lax had been given to the patient for constipation. This had resulted in a bowel movement, which led to an irritant dermatitis. The pat...

Standardized Reporting of the Eczema Area and Severity Index (EASI) and the Patient-Oriented Eczema Measure (POEM): A Recommendation by the Harmonising Outcome Measures for Eczema (HOME) Initiative.

Several organizations from multiple fields of medicine are setting standards for clinical research including protocol development, harmonization of outcome reporting, statistical analysis, quality assessment and reporting of findings. Clinical research standardization facilitates the interpretation and synthesis of data, increases the usability of trial results for guideline groups and shared deci...

A Natural Cream-to-Powder Formulation Developed for the Prevention of Diaper Dermatitis in Diaper-Wearing Infants and Children: Barrier Property and In-Use Tolerance Studies.

Diaper dermatitis is a common condition that develops in the diaper area due to factors such as elevated moisture, increased skin surface pH, and exposure to irritants from urine and feces. These factors suggest interventions to prevent or treat diaper dermatitis such as exposing the skin to air, frequent diaper changes, and thorough cleansing of the diaper area. Barrier creams and powders also ha...

Chronic Nasolabial Fold Seborrheic Dermatitis Successfully Controlled With Crisaborole.

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Use of trolamine to prevent and treat acute radiation dermatitis: a systematic review and meta-analysis.

to evaluate the effects of trolamine in the prevention or treatment of radiation dermatitis.

Tabetri™ ( Ethanol Extract) Ameliorates Atopic Dermatitis Symptoms in Mice.

has been traditionally used as an herbal remedy to alleviate various diseases. However, the plant's pharmacological activity in allergic and inflammatory diseases and its underlying mechanism are not fully understood. Therefore, we investigated the pharmacological activity of Tabetri ( ethanol extract (Ta-EE)) in the pathogenesis of AD. Its underlying mechanism was explored using an AD mouse model...

Optimization of Cytokine Milieu to Reproduce Atopic Dermatitis-related Gene Expression in HaCaT Keratinocyte Cell Line.

Although atopic dermatitis (AD) is characterized by cytokine production predominantly mediated by T helper (Th) 2 cells, AD pathogenesis also involves innate immune and Th1 cells. To optimize the cytokine milieu required for accurate reproduction of AD-related gene expression profile , we evaluated the expression pattern of , , , , , , , , and in human lesional AD skin and cytokine-stimulated HaC...

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