Dermatology Research

19:11 EST 19th November 2017 | BioPortfolio

Efficacy of bleach baths in reducing severity of atopic dermatitis: A systematic review and meta-analysis.

Bleach baths have been proposed as a treatment for decreasing the severity of atopic dermatitis (AD). However, conflicting results have been found regarding their efficacy.

Shiitake mushroom-induced flagellate dermatitis.

Dermatologic surgery, hemophilia and Von Willebrand disease.

Von Willebrand disease (VWD) and hemophilia A and B are the most common types of hereditary coagulation-factor deficiencies. The frequency and type of complications of skin surgery in these patients are unknown. The increasing incidence of skin cancer prompted us to reflect upon this issue. While the incidence of skin cancer is increasing, the complications of skin surgery or ablative laser treatm...

Cutaneous squamous cell carcinomas (SCC) associated with cosmetic skin whitening: 8 cases reported in Senegal.

The cosmetic use of bleaching products is common among women from sub-Saharan Africa. The most frequently used products are highly potent corticosteroids (clobetasol propionate) and hydroquinone. Herein, we report 8 cases of SCC in women using skin bleaching products for cosmetic purposes. Our aim is to describe the epidemiological, clinical and pathological aspects of the carcinomas observed duri...

Skin manifestations of tularemia.

Skin advanced glycation content reflects vaginal tissue glycation level in relation to pregnancy.

A few studies have revealed that the advanced glycation content of the vaginal wall in pelvic organ prolapse tissues is elevated. This elevation makes advanced glycation a significant association with the disease. Early detection of vaginal wall glycation could therefore be relevant in the prevention and management of pelvic organ prolapse. A vaginal wall biopsy to detect this would be ideal, but ...

Essential Role of CARD14 in Murine Experimental Psoriasis.

Caspase recruitment domain family member 14 (CARD14) was recently identified as a psoriasis-susceptibility gene, but its immunological role in the pathogenesis of psoriasis in vivo remains unclear. In this study, we examined the role of CARD14 in murine experimental models of psoriasis induced by either imiquimod (IMQ) cream or recombinant IL-23 injection. In all models tested, the psoriasiform sk...

Primary aldosteronism patients show skin alterations and abnormal activation of glucocorticoid receptor in keratinocytes.

Primary aldosteronism (PA) is a disease characterized by high aldosterone levels caused by benign adrenal tumors being the most frequent cause of secondary hypertension. Aldosterone plays vital physiological roles through the mineralocorticoid receptor (MR) but in certain cell types, it can also activate the glucocorticoid (GC) receptor (GR). Both MR and GR are structurally and functionally relate...

Response to "IL-36 in hidradenitis suppurativa: Evidence for a distinctive pro-inflammatory role and a key factor in the development of an inflammatory loop".

we read with interest the recent paper of Hessam et al.(1) regarding the involvement of IL-36 in hidradenitis suppurativa (HS). They have showed that agonist members of IL-36 were significantly overexpressed in HS lesional skin. This article is protected by copyright. All rights reserved.

The expanding spectrum of clinical phenotypes associated with PSTPIP1 mutations: from PAPA to PAMI syndrome and beyond.

Mutations in the PSTPIP1 gene encoding proline-serine-threonine-phosphatase interactive protein 1 were first identified in an autosomal dominant syndrome called PAPA associated with pyogenic sterile arthritis, pyoderma gangrenosum (PG) and cystic acne.(1,2) . We report a patient with an autoinflammatory syndrome called PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome.(3)...

How well are reporting guidelines and trial registration used by dermatology journals to limit bias? A meta-epidemiological study.

Reporting guidelines were created to ensure research is reported in a transparent, complete manner that minimizes reporting bias. Further, these guidelines assist editors and peer reviewers when reviewing manuscripts for publication and readers when critically appraising published articles (1) . Though reporting guidelines and trial registration have been associated with improved reporting quality...

Liver fibrosis is associated with cutaneous inflammation in the imiquimod-induced murine model of psoriasiform dermatitis.

Psoriasis associates several extra-cutaneous manifestations. Little is known about hepatic parameters specifically associated with psoriasis.

A Phase I Randomised Controlled Trial to Evaluate Safety and Clinical Effect of Topically Applied GSK2981278 Ointment in a Psoriasis Plaque Test.

RORγt, a truncated isoform of retinoic acid receptor-related orphan receptor gamma (RORγ), is a transcription factor involved in Th17 cell differentiation. It is expressed in a few distinct types of immune cells and described as the master regulator of Th17 cytokine expression(1) . RORγ has identical ligand-binding domains as RORγt(2) ; consequently, compounds targeting RORγ are also expected...

Chronic sun exposure is associated with distinct histone acetylation changes in human skin.

Photoaging is attributed to continuous sunlight or artificial UV exposure and manifests the clinical and histological changes of skin. Epigenetic changes have been found to be involved in the pathogenesis of photoaging. However, the underlying mechanisms are unclear.

Poor agreement in questionnaire-based diagnostic criteria for adult atopic dermatitis is a challenge when examining cardiovascular comorbidity.

The association between atopic dermatitis (AD) and cardio-metabolic risk factors is not yet established. Furthermore, no validated questionnaire-based method of identifying adults with AD is currently available.

Q-switched 532nm laser energy causes significant vascular damage in the capillary plexus - how does this affect laser tattoo removal?

Tattoos can be effectively removed using Q-switched and picosecond lasers at four wavelengths - 1064, 755, 694 and 532nm(1,2,3,4) . However, there are two particular problems with the 532nm line. Firstly, it is well absorbed by the melanin in the epidermis, due to its relatively high absorption coefficient(5) , (μa_mel = 56 cm(-1) for typical Caucasian skin). Secondly, 532nm is also strongly abso...

Patient-reported health outcomes in patients with non-melanoma skin cancer and actinic keratosis: Results from a large scale observational study analysing effects of diagnoses and disease progression.

Non-melanoma skin cancer (NMSC) and actinic keratosis (AK) are very common among fair-skinned individuals. A disease continuum from AK to squamous cell carcinoma (SCC) has been frequently postulated. AK and NMSC may influence quality of life (QL) of patients, and it can be suspected that disease progression entails a QL reduction. The purpose of this study was to document QL in patients with NMSC ...

Recognizing the haystack is the task of the primary care physician.

In a reply to our letter Ferrandiz and colleagues wondered why dermoscopy experts did not already fully embrace teledermoscopy (TD) for suspicious pigmented skin lesions.(1) Our study showed that the structure of the health systems that were investigated differed, with countries where primary care physicians (PCP) hold a gate keeper function and others with direct access to a dermatologist. Signif...

Drug Delivery Strategies for Chemoprevention of UVB induced skin cancer: a Review.

Annually, more skin cancer cases are diagnosed than the collective incidence of the colon, lung, breast and prostate cancer. Persistent contact with sunlight is a primary cause for all the skin malignancies. UVB radiation induces reactive oxygen species (ROS) production in the skin which eventually leads to DNA damage and mutation. Various delivery approaches for the skin cancer treatment/preventi...

Effects of blue light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects.

While growing evidence supports the therapeutic effect of 453 nm blue light in chronic inflammatory skin diseases, data on its effects on acutely-perturbed human skin are scarce. In this study we investigated the impact of 453 nm narrow-band LED light on healthy skin following acute perturbation.

Early Occurrence of Sinking Skin Flap Syndrome in a State of Intracranial Hypertension : Case Report.

Prolonging Time to Flare in Pediatric Atopic Dermatitis: A Randomized, Investigator-Blinded, Controlled, Multicenter Clinical Study of a Ceramide-Containing Moisturizer.

Delaying or preventing flares is important in atopic dermatitis (AD) management. The objective of the study was to evaluate whether using a ceramide-containing moisturizer in addition to a body wash during latent AD can delay flares.

Analysis of anti-TNF-induced skin lesions reveals strong Th1 activation with some distinct immunological characteristics.

Psoriasiform and eczematous eruptions are the most common dermatological adverse reaction linked to anti-TNF-α therapy. Yet, a detailed characterization of their immune phenotype is lacking.

High plasma 25-hydroxyvitamin D and high risk of non-melanoma skin cancer: a Mendelian randomisation study of 97849 individuals.

High plasma 25-hydroxyvitamin D (25 (OH)D) concentration has been associated observationally with high risk of non-melanoma skin cancer, while many studies suggest that vitamin D could have a protective effect on cancer. The true association between vitamin D and risk of skin cancer remains unclear.

Collagen: A review on its sources and potential cosmetic applications.

Collagen is a fibrillar protein that conforms the conjunctive and connective tissues in the human body, essentially skin, joints, and bones. This molecule is one of the most abundant in many of the living organisms due to its connective role in biological structures. Due to its abundance, strength and its directly proportional relation with skin aging, collagen has gained great interest in the cos...

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