Diabetes Research

20:31 EDT 22nd July 2018 | BioPortfolio

Comparison of lente insulin and NPH insulin therapy for the treatment of newly diagnosed diabetic dogs: a randomised study.

Clinical studies that compare lente insulin and neutral protamine Hagedorn (NPH) insulin in diabetic dogs are lacking. This is a prospective, randomised, controlled clinical study aimed to compare the efficacy and safety of lente insulin and NPH insulin in diabetic dogs. Thirty client-owned, newly diagnosed diabetic dogs were included. Animals were randomised into two groups and received lente ins...

Neurodegeneration in diabetic retinopathy: does it really matter?

The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now considered a more complex diabetic complication in which neurodegeneration plays a significant role. In this article we provide a critical overview of the role of microvascular abnormalities and neurodegeneration in the pathogenesis of diabetic retinopathy. A special emphasis is placed on the pathophysiol...

MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death.

Testicular apoptotic cell death (TACD) contributes to diabetes mellitus (DM)-induced male infertility. MicroRNA-34a (miR-34a) is a pro-apoptotic RNA that targets sirtuin 1 (SIRT1) which provides protection against complications of (DM). However, the specific role of miR-34a in (DM)-induced TACD is unknown. MiR-34a targets Sirt1 mRNA, resulting in apoptosis. However, whether or not SIRT1 is a majo...

Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus.

Bone mineral density (BMD) is less useful for evaluating fracture risk in type 2 diabetes. This study showed for the first time that combined evaluation by serum insulin-like growth factor-I and BMD is useful to assess the risk of vertebral fracture in postmenopausal women and men with type 2 diabetes.

Reply to Comment to: The relationship between sleep and cognitive function in patients with prediabetes and type 2 diabetes.

Comment to: The relationship between sleep and cognitive function in patients with prediabetes and type 2 diabetes.

Simultaneous Pancreas-Kidney Transplantation Versus Living Donor Kidney Transplantation Alone: an Outcome-Driven Choice?

The choice of optimum transplant in a patient with type 1 diabetes mellitus (T1DM) and chronic kidney disease stage V (CKD V) is not clear. The purpose of this review was to investigate this in more detail-in particular the choice between a simultaneous pancreas-kidney transplantation (SPKT) and living donor kidney transplantation (LDKT), including recent evidence, to aid clinicians and their pati...

Association of the combination of sleep duration and sleep quality with quality of life in type 2 diabetes patients.

Sleep problems are very common in people with diabetes. The aim of this study was to assess the association of the combination of self-reported sleep duration and sleep quality on quality of life (QOL) in Chinese patients with type 2 diabetes mellitus (T2DM).

Optimizing a Hybrid Closed Loop System in Type 1 Diabetes: A Case Report.

We present the optimization of a hybrid closed-loop (HCL) insulin pump system in a type 1 diabetes (T1D) patient in the first 3 months of using the Minimed 670G. An 11-year-old female with 7 years of T1D history started using the Minimed 670G HCL system at our center. The patient had been using the Medtronic Veo insulin pump without a sensor for almost 4 years with HbA1c levels between 7.8% and...

Experiences of self-management among young adults with Type 1 diabetes in the context of a structured education programme: a qualitative study.

To explore the experiences of young adults with regard to self-management of Type 1 diabetes in the context of a structured education programme.

Stroke outcome prediction: what do we know and where are we going?

In this issue of the European Journal of Neurology, the study by Dr. Zhang et al. explored the association between chronic hyperglycemia and either hemorrhagic transformation (HT) or short-term outcome in patients with acute anterior stroke [1]. In a cohort of 426 patients, they found that higher levels of glycosylated hemoglobin (HbA1c) measured in the morning after hospitalization were independ...

Prediction of gestational diabetes mellitus in the Born in Guangzhou Cohort Study, China.

To assess potential risk factors in identifying women at risk for gestational diabetes mellitus (GDM).

Nerve growth factor as an important possible component of novel therapy for cancer, diabetes and cardiovascular diseases.

Nerve growth factor (NGF) is protein discovered by Rita Levi Montalcini in the 1950s. It plays a crucial role in the development of nervous system. NGF may be produced by a variety of cells even beyond nervous system. NGF modulate cell metabolism by binding to p75NTR and TrkA receptors. NGF is involved in psychological processes and may be the possible therapeutical agent for diabetes, cancer and ...

New approaches targeting brown adipose tissue transplantation as a therapy in obesity.

Brown adipose tissue (BAT) is raising high expectations as a potential target in the fight against metabolic disorders such as obesity and type 2 diabetes. BAT utilizes fuels such as fatty acids to maintain body temperature by uncoupling mitochondrial electron transport to produce heat instead of ATP. This process is called thermogenesis. BAT was considered to be exclusive to rodents and human neo...

Effects of trans-resveratrol on type 1 diabetes-induced inhibition of retinoic acid metabolism pathway in retinal pigment epithelium of Dark Agouti rats.

Genesis and progression of diabetic retinopathy are due to glucotoxicity-induced changes in an intracellular milieu in the retina. This study investigated effects of trans-resveratrol on type 1 diabetes-induced changes in gene expressions and retinoic acid metabolism pathway in the RPE (retinal pigment epithelium) of Dark Agouti rats. Microarray analysis showed differential expressions of 833 gene...

Differences in kidney-specific DPP-4 inhibition by linagliptin and sitagliptin.

The two dipeptidyl peptidase (DPP)-4 inhibitors, linagliptin and sitagliptin, were shown to exert different binding kinetics in vitro. Twenty-four hours after oral dosing particularly in vivo inhibition of renal-specific DPP-4 activity was more sustained in Sprague Dawley rats after exposure to linagliptin than it was after sitagliptin.

Longer-term Outcomes in Offspring of GDM Mothers Treated with Metformin versus Insulin.

Insulin has traditionally been the gold standard pharmacological treatment for gestational diabetes mellitus (GDM). Insulin requires multiple injections a day, can cause frequent hypoglycaemia, requires careful handling, and is generally more expensive compared to oral agents. Metformin has been increasingly popular in recent years. Based on the short-term data available, metformin appears to be s...

Antidiabetic activity of polysaccharides from Suillellus luridus in streptozotocin-induced diabetic mice.

Three polysaccharides were extracted from Suillellus luridus (Suilu.A, Suilu.C and Suilu.S) by the hot water-extraction (1:40, w/v) and ethanol precipitation. Their preliminary structures were characterized and their antidiabetic activities were evaluated to obtain the most active component. The results of high performance gel permeation chromatography (HPGPC) and gas chromatograph (GC) showed tha...

Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes.

The emerging concept of the vasculome suggests that microvessels contribute to function and dysfunction in every organ. In the brain, aging and comorbidities such as hypertension and diabetes significantly influence a wide variety of neurodegenerative and cerebrovascular disorders, but the underlying mechanisms are complex and remain to be fully elucidated. Here, we hypothesize that aging, hyperte...

LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling.

Diabetes contributes to cardiovascular complications and the pathogenesis of cardiac remodeling that can lead to heart failure. We aimed to evaluate the functional role of LAZ3 in diabetic cardiomyopathy (DCM). Streptozotocin (STZ) was used to induce a diabetic mouse model. Three months after induction, the mice were subjected to retro-orbital venous plexus injection of adeno-associated virus 9 (A...

Prenatal limb defects: Epidemiologic characteristics and an epidemiologic analysis of risk factors.

To analyze prenatal ultrasound data for fetal limb deformities in high-risk pregnant women and the risk factors for prenatal limb defects in high-risk pregnant women.This was a retrospective study of high-risk pregnant women at the multidisciplinary consultation center from January 2006 to December 2015. When deformities were definitively diagnosed in the first trimester by ultrasound, patients we...


To evaluate retinal dysfunction in diabetic patients who have mild or no nonproliferative diabetic retinopathy (DR) using the high-frequency flicker electroretinogram.

miR-192 prevents renal tubulointerstitial fibrosis in diabetic nephropathy by targeting Egr1.

Diabetic nephropathy (DN), as the most common and serious diabetic microvascular complication, has become the first cause of end-stage renal disease (ESRD) in many countries and regions. However, the pathogenesis of renal fibrosis during the development of DN remains unknown.

Comprehensive Diabetes Self-Management Support From Food Banks: A Randomized Controlled Trial.

To determine whether food bank provision of self-management support and diabetes-appropriate food improves glycemic control among clients with diabetes.

Community Health Workers, Access to Care, and Service Utilization Among Florida Latinos: A Randomized Controlled Trial.

To determine whether a 1-year community health worker intervention improves access to care and service utilization among Latinos with diabetes.

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