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Ertugliflozin Research

19:27 EST 21st February 2019 | BioPortfolio

Diabetes Technology and the Human Factor.

Technologies in Diabetes-the Tenth ATTD Yearbook.

Ginseng Extract Modified by Pectin Lyase Inhibits Retinal Vascular Injury and Blood-Retinal Barrier Breakage in a Rat Model of Diabetes.

GS-E3D is an enzymatically modified ginseng extract by pectin lyase. In this study, we evaluated the preventive effects of GS-E3D on blood-retinal barrier (BRB) leakage in a rat model of diabetes. To produce diabetes, rats were injected with streptozotocin. GS-E3D was orally gavaged at 25, 50, and 100 mg/kg body weight for 6 weeks. We then compared the effect of GS-E3D with that of an unmodified...

Repercussions of low fructose-drinking water in male rats.

Fructose consumption has increased worldwide, and it has been associated with the development of metabolic diseases such as insulin resistance (IR) and steatosis. The aim was to evaluate if lower fructose concentrations may cause pancreatic structural abnormalities, leading to a glucose intolerance without steatosis in male rats. Young male rats orally received 7% fructose solution for 12 weeks. B...

Cut-Point for Satisfactory Adherence of the Dietary Sodium Restriction Questionnaire for Patients with Heart Failure.

The low or non-adherence to reduction of sodium intake has been identified as one of the main precipitating factors of heart failure (HF). The Dietary Sodium Restriction Questionnaire (DSRQ) identifies factors that can interfere with adherence to this recommendation. However, there is still no cut-point to define adherence for this questionnaire.

Evaluating Sodium Restriction in Heart Failure.

Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes.

Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes.

Systematic review of randomized controlled trials on antibiotic treatment for osteomyelitis in diabetes.

To evaluate the efficacy of antibiotic therapy in osteomyelitis treatment among people with diabetes.

Dietary intakes of women with Type 1 diabetes before and during pregnancy: a pre-specified secondary subgroup analysis among CONCEPTT participants.

To describe the dietary intakes of women with Type 1 diabetes before and during pregnancy.

Comment on the consensus report on the management of hyperglycaemia in Type 2 diabetes by the American Diabetes Association and the European Association for the Study of Diabetes.

We read with interest the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) joint consensus report on the management of hyperglycaemia in Type 2 diabetes. Following publication of the report, discussions of the content among networks of behavioural and educational researchers prompted us to write this letter. This consensus report is to be commended ...

Fixed-ratio combination of insulin degludec and liraglutide (IDegLira) improves cardiovascular risk markers in patients with type 2 diabetes uncontrolled on basal insulin.

This post hoc analysis investigated effects of insulin degludec/liraglutide fixed-ratio combination (IDegLira) versus comparators on cardiovascular (CV) risk markers from DUAL II (versus insulin degludec), DUAL V (versus insulin glargine 100 units/mL) and DUAL VII (versus basal-bolus therapy) in patients grouped by sex, age (

The role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycemia.

Patients with gastric bypass surgery (GB) have enhanced postprandial hyperinsulinemia and incretin effect. Here we sought to determine the effect of vagal activation, a neural component of the enteroinsular axis, on postprandial glucose metabolism in patients with and without hypoglycemia after GB. Seven subjects with documented post-GB hypoglycemia (HGB), 7 GB subjects without hypoglycemia (AGB),...

The skin as « third kidney ».

The skin is the largest human organ playing an important role in protection, thermoregulation and sensation. Recent studies suggest that a new function has to be added: the storage of sodium. There is increasing evidence that sodium can accumulate in the skin, which suggests that the skin contributes to the regulation of sodium balance in humans, and possibly to the control of extracellular volume...

Hepatorenal syndrome : something new?

Hepatorenal syndrome is a serious and frequent complication in patients suffering from liver cirrhosis. Its most severe type is characterized by the rapid occurrence of a functional acute kidney injury. However it is mainly an exclusion diagnosis. Although the pathophysiology is not yet fully understood, the principal hypothesis is a splanchnic vasodilatation leading to a systemic and renal vasoco...

Short Telomere Subtelomeric Hypomethylation is associated with Telomere Attrition in Elderly Diabetic Patients.

Telomere shortening is well known to be associated with the aging process and aging-associated diseases, including diabetes. The telomere length and subtelomeric methylation status in peripheral leucocytes (LTL) were compared in elderly type 2 diabetes patients (T2D) and diabetes free controls (C). The methylation status was analyzed the between of MspI-TRF lengths and HpaII-TRF lengths by using m...

Continuous Glucose Monitoring in Children with Type 1 Diabetes Improves Well-Being, Alleviates Worry and Fear of Hypoglycemia.

There is limited published evidence regarding the psychological effect of use of continuous glucose monitoring (CGM) in the pediatric population with type 1 diabetes mellitus on metabolic control, fear of hypoglycemia, and patient or carer well-being. The aim of this study was to evaluate the effects of CGM on patient and carer well-being, worry, fear of hypoglycemia, and glycemic control.

Contributions of Rho-kinase and AMP-related kinase (AMPK) Signaling Pathways to Endothelium-Derived Contracting Factors (EDCF)-mediated Responses in Diabetic Rat Aorta.

Diabetes-induced endothelium damage leads to vascular dysfunction. The current study was designed to determine the effects of short-term (4-week) streptozotocin (STZ)-induced diabetes on endothelium-derived contracting factors (EDCF)-mediated responses with possible contributions of Rho-kinase and AMP-activated kinase (AMPK) signaling pathways. The effects of STZ-diabetes on vascular functions wer...

A Multilevel Intervention With African American Churches to Enhance Adoption of Point-of-Care HIV and Diabetes Testing, 2014-2018.

We describe a multilevel intervention to enhance adoption of point-of-care HIV and diabetes testing at church health fairs in Atlanta, Georgia. Church leaders viewed a leadership video and subsequently conducted social activities that support testing. After the multilevel intervention, a third of churches hosted HIV and diabetes health fairs, and church leaders engaged in more social activities. O...

High glucose-induced ubiquitination of G6PD leads to the injury of podocytes.

Oxidative stress contributes substantially to podocyte injury, which plays an important role in the development of diabetic kidney disease. The mechanism of hyperglycemia-induced oxidative stress in podocytes is not fully understood. Glucose-6-phosphate dehydrogenase (G6PD) is critical in maintaining NADPH, which is an important cofactor for the antioxidant system. Here, we hypothesized that high ...

The risk factors for diabetic peripheral neuropathy: A meta-analysis.

Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabeti...

Association of cardiovascular autonomic dysfunction with peripheral arterial stiffness in patients with type 1 diabetes.

Cardiovascular autonomic (CAN) neuropathy appears to contribute to peripheral arterial stiffness (AS) in type 1 diabetes. If CAN in patients with AS is associated to concomitant asymptomatic atherosclerotic disease (aPAD) remains unclear.

Association of vaspin rs2236242 gene variants with type 2 diabetes and obesity in a Chinese population: A prospective, single-center study.

Vaspin is an adipokine separated from visceral fat tissues of obese diabetic rats. This study was to investigate the association between vaspin rs2236242 gene polymorphism and type 2 diabetes mellitus (T2DM) or obesity in a Chinese population.

Birth weight and risk of type 2 diabetes mellitus: a dose-response meta-analysis of cohort studies.

The association between birth weight and type 2 diabetes mellitus has been debated for several decades, and the dose-response relationship has not been reported. The objective of this systematic review and meta-analysis was to quantitatively clarify the association between birth weight and risk of type 2 diabetes mellitus based on cohort studies.

Bundled Defect-Rich MoS for a High-Rate and Long-Life Sodium-Ion Battery: Achieving 3D Diffusion of Sodium Ion by Vacancies to Improve Kinetics.

Molybdenum disulfide (MoS ), a 2D-layered compound, is regarded as a promising anode for sodium-ion batteries (SIBs) due to its attractive theoretical capacity and low cost. The main challenges associated with MoS are the low rate capability suffering from the sluggish kinetics of Na intercalation and the poor cycling stability owning to the stack of MoS sheets. In this work, a unique architecture...

Diabetes Alters pH Control in Rat Retina.

The purpose of this study was to determine whether the ability of the rat retina to control its pH is affected by diabetes.

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