Gallbladder Disease Research

23:51 EDT 21st October 2018 | BioPortfolio

Differential effects of cholecystokinin (CCK-8) microinjection into the ventrolateral and dorsolateral periaqueductal gray on anxiety models in Wistar rats.

Cholecystokinin (CCK) is one of the main neurohormone peptide systems in the brain, and a major anxiogenic mediator. The periaqueductal gray (PAG) is a key midbrain structure for defensive behaviors, which could include anxiety, fear, or even panic. The CCK system has wide distribution in the PAG, where the dorsolateral region (DL) participates in active defensive behavior and the ventrolateral re...

Evaluating the effectiveness of perioperative use of intravenous dexamethasone in the success of management of congenital nasolacrimal duct obstruction with balloon dacryoplasty.

To evaluate the effect of perioperative dexamethasone, presumed to reduce edema, on the success rate of nasolacrimal duct obstruction (NLDO) treatment by balloon dacryoplasty.

Micropercutaneous nephrolithotomy versus retrograde intrarenal surgery in the treatment of renal stones: A systematic review and meta-analysis.

To compare the efficacy and safety of micropercutaneous nephrolithotomy (Microperc) and retrograde intrarenal surgery (RIRS) in treating renal stones using published literature.

Percutaneous Transgastral biliodigestive diversion as treatment option for BRIC.

A 51-year-old woman was hospitalized with jaundice, pruritus and nausea. Four weeks before a common bile duct stone had been removed by endoscopic retrograde cholangiopancreatography (ERCP) with papillotomy. Blood tests showed isolated bilirubinaemia (15 mg/dl), while all liver enzymes were in the normal range. In a second ERCP we saw a wide opened major papilla with unimpaired bile flow and witho...

Performance measures for ERCP and endoscopic ultrasound: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.

The European Society of Gastrointestinal Endoscopy and United European Gastroenterology present a short list of key performance measures for endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP). We recommend that endoscopy services across Europe adopt the following seven key and one minor performance measures for EUS and ERCP, for measurement and evaluation in dail...

The effect of phosphodiesterase-5 inhibitor, tadalafil, on potassium chloride-induced contractions of isolated human ureteral tissue.

Drugs causing ureteral relaxation are used for medical expulsive therapy (MET) for stones. We investigated the ability of tadalafil to cause relaxation of potassium chloride (KCl)-induced contractions of isolated human ureteral tissue.

Concurrent Microbial Keratitis and Nasolacrimal Duct Obstruction: Concordance, Etiopathogenesis, and Outcome.

Nasolacrimal duct obstruction (NLDO) is believed to be a risk factor for microbial keratitis (MK). The primary objective of this study was to look at microbiological concordance between corneal scraping and lacrimal sac flora in patients with concurrent MK and NLDO. The secondary objective was to compare microbiological isolates from MK and NLDO, MK alone, NLDO alone, and healthy subjects.

Flaxseed meal and oat hulls supplementation: Impact on dietary fiber digestibility, and flows of fatty acids and bile acids in growing pigs.

The present study was conducted to determine the effects of adding flaxseed meal or oat hulls in pigs' diets on digestibility of dietary fiber (DF) and fatty acids (FA), and gastrointestinal flows of FA and bile acids (BA). Twelve Genesus [(Duroc♂ × Yorkshire-Landrace♀)] cannulated barrows (initial BW: 35.1 ± 0.44 kg) were individually housed and offered diets in a 2-period cross-over design...

Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action.

Intrahepatic cholestasis of pregnancy is characterised by pruritus and elevated serum bile acids. The pruritus can be severe, and pharmacological options achieve inconsistent symptomatic improvement. Raised bile acids are linearly associated with adverse fetal outcomes, with existing management of limited benefit. We hypothesised that therapeutic plasma exchange removes pruritogens and lowers tota...

Formation of a bile salt-drug hydrogel to predict human intestinal absorption.

The unique character of bile salts to self-assemble into hydrogels in the presence of halide salts was exploited in this work to facilitate the prediction of human intestinal absorption (%HIA) for a set of 25 compounds. This was achieved by firstly incorporating each compound separately within the process of gel formation to create a series of gel-drug membranes. Scanning Electron Microscopy (SEM)...

Manifestation of hydatid cyst of liver with pancreatitis, cholangitis and jaundice: A case report.

Hydatid disease or echinococcosis, a systemic zoonosis is caused by Echinococcusgranulosus larvae. This is a common disease found all over the world, especially in the Mediterranean region. We report a 40 year old male with no known comorbids who came with complaints of fever with rigors and chills, right hypochondriac pain, and yellow discolouration of the sclera. A CT scan abdomen with endoscopi...

ASO Author Reflections: Gallbladder Cancer Predictive Risk Score Based on Pathological Findings: A Propensity Score-Matched Analysis.

Comparison of intestinal expression of the apical sodium-dependent bile acid transporter between dogs with and without chronic inflammatory enteropathy.

Intestinal absorption of bile acids is mediated by the apical sodium-dependent bile acid transporter (ASBT). Fecal bile acid dysmetabolism has been reported in dogs with chronic inflammatory enteropathy (CIE).

Experimentally induced biliary atresia by means of rotavirus-infection is directly linked to severe damage of the microvasculature in the extrahepatic bile duct.

Vascular damage has been reported to contribute to atresia formation in several diseases including biliary atresia. This study focused on the extrahepatic biliary plexus in experimental biliary atresia.

Effect of antithrombic therapy on bleeding complications in patients receiving emergency cholecystectomy for acute cholecystitis.

The risk of developing hemorrhagic complications during or after emergency cholecystectomy in patients with antithrombic therapy (ATT) remains uncertain. In this study, we evaluate outcomes in patients with ATT undergoing emergency cholecystectomy and assess the relevance between ATT and perioperative complications including bleeding complications.

Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy.

The repression of renal Farnesoid X Receptor (FXR) had been shown to result from lack of bile acid production from cirrhotic liver. We hypothesized that silymarin and rosuvastatin (Rvs) could have a hepatorenal therapeutic effects in hepatic nephropathy through induction of FXR.

Stone in the distal jejunum presenting as small bowel obstruction: A case report.

Gallstone ileus is a rare presentation of cholelithiasis accounting for around 4% of cases of small bowel obstruction under 65 years of age but rises to 25% in those more than 65 years of age. Most gall stones, if impact in the bowel, are seen to lodge at the ileocecal valve as this is the most narrow part of the bowel.

A case of obstructive jaundice due to early carcinoma of the cystic duct protruding into the common bile duct.

Cystic duct carcinoma is a rare disease, and only 33 cases reported worldwide have completely fulfilled the criteria first established by Farrar in 1951. Here we describe an extremely rare case of early cystic duct carcinoma that fulfilled the Farrar criteria, the papillary tumour protruding into the common bile duct, leading to obstructive jaundice.

Obesity and stones.

The incidence of urolithiasis has shown a prominent increase in the last two to three decades and evidence-based data have clearly indicated the certain role of obesity and overweight in both children and adults. As a certain component of metabolic syndrome, 'obesity' has been found to have a significant impact on the urinary metabolic risk factors which may be important in stone formation. In thi...

Chronological changes in epidemiological characteristics of lower urinary tract urolithiasis in Japan.

To determine changes and trends in the annual incidence and epidemiological aspects of lower urinary tract stones in Japan.

A rare case of paraganglioma of the cystic duct.

Biliary system paragangliomas are rare neuroendocrine tumors of embryonic neural crest origin. The majority is asymptomatic and incidentally found due to gallbladder functional disorders. Herein, we present a non-functional, 2.25 mm focus in the cystic duct, which to our knowledge, is the first reported paraganglioma of the cystic duct.

A Novel Approach for Incisionless Stone Management: Transpapillary Lumen-Apposing Metal Stent for Duct Clearance and Cholangioscopy Access.

Morphological characterization of small hepatocytes after bile duct ligation in chicken.

Small hepatocytes have hepatocyte-like characteristics and high proliferation activity. Most small hepatocyte studies report on in vitro rat or human hepatocytes. Only a few studies of small hepatocytes after bile duct ligation have been reported, and none of these have focused on these cells in birds. In this study, small hepatocytes appearing in bile duct ligation chicken liver were examined usi...

A case of EUS-guided pancreatic duct rendezvous stenting in which initial contrast medium injection was useful for the second puncture.

Endoscopic ultrasonography guided pancreatic duct drainage (EUS-PD) has been reported as an alternative to surgery in cases where trans-papillary access to the main pancreatic duct (MPD) is not feasible. However, this technique has been reported as a challenging procedure in clinical practice. (1-5). A 64-year-old man presented with repeat pancreatitis caused by a post endoscopic sphincterotomy sc...

Single extracorporeal shock-wave lithotripsy for proximal ureter stones: Can CT texture analysis technique help predict the therapeutic effect?

To explore whether the computed tomography texture analysis (CTTA) technique can help predict the curative effects of a single extracorporeal shock-wave lithotripsy (ESWL) for proximal ureteral stones.

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