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Generics Drugs Research

07:28 EST 7th December 2019 | BioPortfolio

Deep Regionlets: Blended Representation and Deep Learning for Generic Object Detection.

In this paper, we propose a novel object detection algorithm named "Deep Regionlets" by integrating deep neural networks and conventional detection schema for accurate generic object detection. Motivated by the advantages of regionlets on modeling object deformation and multiple aspect ratios, we incorporate regionlets into an end-to-end trainable deep learning framework. The deep regionlets frame...

Near infrared (NIR)-spectroscopy and in-vitro dissolution absorption system 2 (IDAS2) can help detect changes in the quality of generic drugs.

While Health authorities in Panama strive to increase generic drug use to contain the rising costs of medicines, there is still hesitation to embrace generic drugs. Thus, regulators and drug companies need to ensure the quality, safety and efficacy of generic drugs. One prevailing concern is the absence of control over lot-to-lot changes, which may impact consistent therapeutic performance. The ob...

The Study of Generic Model Set for Reducing Calibration Time in P300-based Brain-Computer Interface.

P300-based brain-computer interfaces (BCIs) provide an additional communication channel for individuals with communication disabilities. In general, P300-based BCIs need to be trained, offline, for a considerable period of time, which causes users to become fatigued. This reduces the efficiency and performance of the system. In order to shorten calibration time and improve system performance, we i...

Expert-based development of a generic HACCP-based risk management system to prevent critical negative energy balance in dairy herds.

The objective of this study was to develop a generic risk management system based on the Hazard Analysis and Critical Control Point (HACCP) principles for the prevention of critical negative energy balance (NEB) in dairy herds using an expert panel approach. In addition, we discuss the advantages and limitations of the system in terms of implementation in the individual dairy herd. For the expert ...

Active inference as a unifying, generic and adaptive framework for a P300-based BCI.

Going adaptive is a major challenge for the field of Brain-Computer Interface (BCI). This entails a machine that optimally articulates inference about the user's intentions and its own actions. Adaptation can operate over several dimensions which calls for a generic and flexible framework.

Towards a generic method for ion chromatography-mass spectrometry of low molecular weight amines in pharmaceutical drug discovery and development.

Low molecular weight amines are encountered in pharmaceutical analysis e.g. as reactants in chemical syntheses, but are challenging to analyse by ultra-high-performance liquid chromatography-mass spectrometry (UHPLC/MS) due to their high polarity causing poor retention. Ion chromatography-MS (IC-MS) is an emerging technique for polar molecule analysis that offers better separation. A generic IC-MS...

Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System.

Vachellia and Senegalia are the most important genera in the subfamily Mimosoideae (Fabaceae). Recently, species from both genera were separated from the long-characterized Acacia due to their macro-morphological characteristics. However, this morpho-taxonomic differentiation struggles to discriminate some species, for example, Vachellia nilotica and Senegalia senegal. Therefore, sequencing the ch...

Post-marketing assessment of generic tamoxifen in Brazilian breast cancer patients.

Generic formulations of tamoxifen are commonly prescribed to estrogen receptor-positive breast cancer patients at the Brazilian National Cancer Institute (INCA). We carried out a post-marketing surveillance of the generic tamoxifen formulation in current use at INCA, by comparing plasma concentrations of the parent drug and metabolites obtained with the generic versus the reference formulation. Th...

Dawn of a New Era of Targeted Antioxidant Therapies.

In this issue of Cell Chemical Biology, Shah et al. (2019) report an in vitro, high-throughput assay that predicts the ability of compounds to suppress peroxidation of phospholipids. This approach provides a way to design and optimize targeted antioxidants that suppress specific oxidative event in cells, potentially overcoming previous failures with generic antioxidants.

Image-based 3D Object Reconstruction: State-of-the-Art and Trends in the Deep Learning Era.

3D reconstruction is a longstanding ill-posed problem, which has been explored for decades by the computer vision, computer graphics, and machine learning communities. Since 2015, image-based 3D reconstruction using convolutional neural networks (CNN) has attracted increasing interest and demonstrated an impressive performance. Given this new era of rapid evolution, this article provides a compreh...

Price dispersion of generic medications.

Generic pharmaceuticals should have very little price dispersion. Economics' Law of One Price suggests that identical goods, in the absence of trade frictions and under conditions of free competition and price flexibility, should sell for the same price, and the FDA ensures that generics are identical. In this study, we examine whether generic pharmaceuticals indeed have the low price dispersion t...

The unexpected consequences of generic entry.

Generic drugs are sold at a fraction of the original brand price. Yet, generic entry typically produces a drop in the quantity market share of the molecule losing exclusivity. This effect is economically and statistically significant for a large dataset covering hundreds of prescription drugs sold in the US during the period 1994Q1-2003Q4. This paper proposes the first systematic analysis of what ...

Sofosbuvir-/Daclatasvir-based therapy for chronic HCV and HCV/hepatitis B virus coinfected patients in Egypt.

Dramatic advances in hepatitis C virus (HCV) treatment were witnessed with the introduction of direct-acting antivirals (DAAs). Generic DAAs with remarkable efficacy and good safety profiles are currently manufactured by local pharmaceutical companies in Egypt.

Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs.

Despite the importance of pharmacopeial standards, little is known regarding their effect on drug competition. Such information is of particular relevance given the rising costs of prescription drugs and the focus of policy-makers and other stakeholders on addressing these costs. We examined 982 prescription drugs approved by U.S Food and Drug Administration since 1982 to examine the association b...

Novel text analytics approach to identify relevant literature for human health risk assessments: A pilot study with health effects of in utero exposures.

Systematic reviews involve mining literature databases to identify relevant studies. Identifying potentially relevant studies can be informed by computational tools comparing text similarity between candidate studies and selected key (i.e., seed) references. Challenge Using computational approaches to identify relevant studies for risk assessments is challenging, as these assessments examine multi...

The stability of leading-edge vortices to perturbations on samara-inspired rotors: A novel solution for gust resistance.

The stability of leading-edge vortices (LEVs) on a samara-inspired rotor during steady and unsteady gusty incoming flow was investigated experimentally using direct rotational speed measurements, as well as time-resolved particle image velocimetry (PIV). The blades of the samara-inspired rotor were designed to match the tip-speed ratio, the aspect ratio, and the distribution of the effective angle...

Evaluation of the physical health of adolescent in-patients in generic and secure services: retrospective case-note review.

To assess physical health needs of adolescent in-patients by routine monitoring. A retrospective analysis of case notes was conducted on a 6-month intake to generic and secure adolescent mental health units in Greater Manchester, UK.

Reduction of the rocuronium-induced withdrawal reflex by MR13A10A, a generic rocuronium with a novel solution: A randomized, controlled study.

Rocuronium induces venous pain and the withdrawal reflex during injection. MR13A10A, generic rocuronium with a novel solution, reduced the injection-induced withdrawal reflex in rodents. We hypothesized that MR13A10A would reduce the frequency and severity of injection-induced withdrawal reflexes compared with original rocuronium during clinical anesthesia induction.

Physicians' opinions on generic antiretroviral drugs and single-tablet regimen de-simplification for the treatment of HIV infection: a multicentre survey in Spain.

To assess the attitudes and opinions about generic antiretroviral drugs (ARVs) and single-tablet regimen (STR) de-simplification among physicians prescribing HIV treatment in the cohort of the Spanish HIV/AIDS Research Network (CoRIS).

Cradles and museums of generic plant diversity across tropical Africa.

Determining where species diversify (cradles) and persist (museums) over evolutionary time is fundamental to understanding the distribution of biodiversity and for conservation prioritization. Here, we identify cradles and museums of angiosperm generic diversity across tropical Africa, one of the most biodiverse regions on Earth. Regions containing non-random concentrations of young (neo-) and old...

Robust, real-time generic detector based on a multi-feature probabilistic method.

Robust, real-time event detection from physiological signals acquired during long-term ambulatory monitoring still represents a major challenge for highly-artifacted signals. In this paper, we propose an original and generic multi-feature probabilistic detector (MFPD) and apply it to real-time QRS complex detection under noisy conditions. The MFPD method calculates a binary Bayesian probability fo...

Cladribine repurposed in multiple sclerosis: making a fortune out of a generic drug.

A Generic Quality Control Framework for Fetal Ultrasound Cardiac Four-chamber Planes.

Quality control / assessment of ultrasound (US) images is an essential step in clinical diagnosis. This process is usually done manually, suffering from some drawbacks, such as dependence on operator's experience and extensive labors, as well as high inter- and intra-observer variation. Automatic quality assessment of US images is therefore highly desirable. Fetal US cardiac four-chamber plane (CF...

Development of a generic physiologically based kinetic model to predict in vivo uterotrophic responses induced by estrogenic chemicals in rats based on in vitro bioassays.

The present study assessed the potential of a generic PBK model to convert in vitro data for estrogenicity to predict the in vivo uterotrophic response in rats for diethylstibestrol (DES), ethinylestradiol (EE2), genistein (GEN), coumestrol (COU) and methoxychlor (MXC). PBK models were developed using a generic approach and in vitro concentration-response data from the MCF-7 proliferation assay an...

Is Bioequivalence a Sufficient Measure of Equivalence?

This article reviews the U.S. Food and Drug Administration (FDA) regulation of generic medications-specifically, the use of bioequivalence to compare generic and brand prescriptions. New or "brand" drugs are subjected to extensive review by the FDA before they can be marketed to the public. Generics, which are posited to be identical to brands, are subject to a less extensive review process and mu...

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