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Gout Research

05:34 EST 22nd February 2019 | BioPortfolio

A Model of Uric Acid Transport in the Rat Proximal Tubule.

The objective of this study was to investigate theoretically the mechanisms underlying uric acid transport in the proximal tubule (PT) of rat kidneys, and their modulation by factors including Na, parathyroid hormone (PTH), Angiotensin II, and SGLT2 inhibitors. To that end, we incorporated the transport of uric acid and its conjugate anion urate in our mathematical model of water and solute transp...

Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass1.

To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation.

Erratum to: Automatic quantification of bone marrow edema on MRI of the wrist in patients with early arthritis: A feasibility study (Magn Reson Med. 2018; 79:1127-1134).

Surface Functionalization of Magnetite Nanoparticles with Sulfonic Acid and Heteropoly Acid: Efficient Magnetically Recoverable Solid Acid Catalysts.

New magnetically recoverable solid acid catalysts for acid-catalyzed reactions were designed via the surface chemical functionalization of silica-coated magnetite nanoparticles (SCMNPs) with sulfonic acid groups. First, the SCMNPs were covalently functionalized with 3-aminopropyl groups to achieve Amp-SCMNPs. Then, reaction of the Amp-SCMNPs with 1,4-butane sultone followed by acidification with p...

Ultrasound and clinical features of hip involvement in patients with gout.

To investigate the prevalence of the ultrasound findings indicative of monosodium urate crystal deposits at the hip joint in patients with gout and to explore the association between the ultrasound findings and the clinical and serological features.

Water-born zirconium-based metal organic frameworks as green and effective catalysts for catalytic transfer hydrogenation of levulinic acid to γ-valerolactone: Critical roles of modulators.

While zirconium (Zr)-based metal organic frameworks (MOFs) are promising for conversion of levulinic acid (LA) to γ-valerolactone (GVL) through catalytic transform hydrogenation (CTH), these reported Zr MOFs for LA conversion must be synthesized in toxic dimethylformamide (DMF). From the viewpoint of sustainability, it is preferable to avoid usage of DMF-based solvents to prepare these Zr MOFs. A...

Quinaldic acid induces changes in the expression of p53 tumor suppressor both on protein and gene level in colon cancer LS180 cells.

Origin, synthesis and activity of quinaldic acid (QA), proposed derivative of kynurenic acid, have been poorly studied to date. Previously, we have demonstrated the antiproliferative effect of QA in a colon cancer model in vitro. The goal of present study was to verify QA activity to modify the expression of p53 tumor suppressor in colon cancer cells, and to relate it to its cancer cell growth inh...

Effect of Steaming Processing on Phenolic Profiles and Cellular Antioxidant Activities of .

The intention of this study was to investigate the effect of steaming processing on phenolic profiles and antioxidant activities in chestnuts. Steaming processing at different times and temperatures depicted diverse impacts on free and bound fractions. Though, bound phenolics were stable but long time steaming at higher temperatures tended to improve the levels of phenolics, flavonoids as well as ...

Antihyperlipidemic Effect, Identification and Isolation of the Lipophilic Components from Artemisia integrifolia.

L (Compositae) is a medicinal and edible plant. To investigate its antihyperlipidemic effect, a crude lipophilic extract and the composing compounds were isolated and fractioned from the petroleum ether extract of aerial parts of using column chromatography on silica gel. The anti-hyperlipidemia effect was studied in a rat model of acute hyperlipidemia, which was induced by triton WR-1339. A new ...

Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins.

Hypoxia poses a stress to cells and decreases mitochondrial respiration, in part by electron transport chain (ETC) complex reorganization. While metabolism under acute hypoxia is well characterized, alterations under chronic hypoxia largely remain unexplored. We followed oxygen consumption rates in THP-1 monocytes during acute (16 h) and chronic (72 h) hypoxia, compared to normoxia, to analyze the...

Positive Impact of Pulsed Electric Field on Lactic Acid Removal, Demineralization and Membrane Scaling during Acid Whey Electrodialysis.

The drying of acid whey is hindered by its high mineral and organic acid contents, and their removal is performed industrially through expensive and environmentally impacting serial processes. Previous works demonstrated the ability to remove these elements by electrodialysis alone but with a major concern-membrane scaling. In this study, two conditions of pulsed electric field (PEF) were tested a...

Folic Acid and Vitamin B12 Administration in CKD, Why Not?

Patients affected by chronic kidney disease (CKD) or end-stage renal disease (ESRD) experience a huge cardiovascular risk and cardiovascular events represent the leading causes of death. Since traditional risk factors cannot fully explain such increased cardiovascular risk, interest in non-traditional risk factors, such as hyperhomocysteinemia and folic acid and vitamin B12 metabolism impairment, ...

Predictors of Uric Acid Stones: Mean Stone Density, Stone Heterogeneity Index, and Variation Coefficient of Stone Density by Single-Energy Non-Contrast Computed Tomography and Urinary pH.

We analyzed the capacities of pertinent parameters (determined by single-energy non-contrast computed tomography [NCCT]) and urinary pH to predict uric acid stones. We reviewed the medical records of 501 patients whose stones were removed surgically or passed spontaneously between December 2014 and April 2016. Qualifying participants ( = 420) were stratified by the nature of the stone (calcium oxa...

The Effect of Buffers on Weak Acid Uptake by Vesicles.

The assessment of weak acid membrane permeability () frequently involves large unilamellar vesicles. It relies on measurements of the intravesicular pH drop, ΔpH, in response to a sudden augmentation of external acid concentration. However, ΔpH may be primarily governed by non-instantaneous protonation and deprotonation reactions of (i) the acid itself, (ii) the buffer molecules, and (iii) the f...

Irisin as a new marker for the early diagnosis of low-traumatic fractures in rheumatoid arthritis.

The aim of this study was to study the relationship between serum irisin level and the presence of low-traumatic bone fractures in rheumatoid arthritis (RA) patients. We examined 170 people including 110 RA patients and 60 healthy individuals as comparison group. The serum irisin level was determined with solid-phase enzyme-linked immunosorbent assay using ELISA Irisin test system (BioVendor, cat....

Paradoxical Arthritis in Inflammatory Bowel Diasease Patients on Ustekinumab Treatment.

Decarboxylation with Carbon Monoxide: The Direct Conversion of Carboxylic Acids into Potent Acid Triflate Electrophiles.

We report a new strategy for the conversion of carboxylic acids into potent acid triflate electrophiles. The reaction involves oxidative carbonylation of carboxylic acids with I2 in the presence of AgOTf, and is postulated to proceed via acyl hypoiodites that react with CO to form acid triflates. Coupling this chemistry with subsequent trapping with arenes offers a mild, room temperature approach ...

Role of esterase mediated hydrolysis of simvastatin in human and rat blood and its impact on pharmacokinetic profiles of simvastatin and its active metabolite in rat.

Simvastatin is known as a pro-drug, which could be hydrolyzed by esterases to its active form, simvastatin acid. Although pharmacokinetics of simvastatin and simvastatin acid have been widely studied, hydrolysis of simvastatin to simvastatin acid during blood sampling and plasma preparation has been overlooked in the previous studies, leading to underestimation of simvastatin concentration and ove...

Design, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents.

Cinnamic acid and its derivatives are known for anti-tubercular activity. The present study reports the synthesis of cinnamic acid derivatives via bioisosteric replacement of terminal carboxylic acid with "oxadiazole". A series of cinnamic acid derivatives (styryl oxadiazoles) were designed and synthesized in good yields by reaction of substituted cinnamic acids (2, 15a-15s) with amidoximes. The s...

Ozone initiated heterogeneous oxidation of unsaturated carboxylic acids by ATR-FTIR spectroscopy.

Despite considerable effort has been directed to ozone-initiated heterogeneous oxidation of unsaturated organic species in atmospheric environment, current knowledge about how chemical structure of unsaturated carboxylic acids affects their reaction kinetics remains very limited. Here, kinetics of heterogeneous reaction of ozone with six unsaturated fatty acids (oleic acid, vaccenic acid, eladic a...

Abatacept initiation in rheumatoid arthritis and the risk of serious infection: A population-based cohort study.

To assess whether abatacept as initial biologic disease-modifying antirheumatic drug (DMARD) in the treatment of rheumatoid arthritis is associated with an increased risk of serious infections, including bone and joint, gastrointestinal, respiratory tract, skin and soft tissue, and urinary tract, when compared with other biologic DMARDs.

Biochemical investigations performed in pericardial fluid in forensic cases that underwent postmortem angiography.

Postmortem biochemical investigations in vitreous humor samples collected before and after performing multiphase postmortem computed tomography angiography were performed in the past and demonstrated that specific contrast material injection allowed perfusion and radiological identification of the main vessels of the eye to be obtained without any changes in vitreous humor composition. In the stud...

A role of PSA-NCAM in the survival of retinal ganglion cells (RGCs) after kainic acid damage.

Neural cell adhesion molecule (NCAM) belongs to the immunoglobulin superfamily of adhesion molecules. Polysialic acid (PSA) is attached to NCAM post-translationally. PSA residues are considered to reduce the adhesive properties of NCAM and play an important role in the regulation of cell interactions. PSA-NCAM is largely expressed in the mature retina by glial cells adjacent to retinal ganglion ce...

Silicic acid: The omniscient molecule.

We contend that silicic acid is a much under-valued molecule and specifically in the context of its role in establishing and maintaining life on Earth. Silicic acid can also be an ill-understood molecule with its chemistry all too often confused with that of either silicates or silica. Herein we (i) provide a working definition for silicic acid; (ii) identify its omnipresent role in biochemical ev...

Single-step pyrolysis of phosphoric acid-activated chitin for efficient adsorption of cephalexin antibiotic.

Cephalexin (CFX) antibiotic, a potent pharmaceutical water pollutant, was efficiently removed by activated carbon (AC) derived from a single-step pyrolysis of phosphoric acid-activated chitin. Experimental conditions such as temperature, CFX initial concentration, and solution pH were screened in batch adsorption. Phosphoric acid activation of chitin and subsequent pyrolysis tailored the Brunauer-...

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