Headache Research

08:17 EST 16th February 2019 | BioPortfolio

Temporomandibular Disorder: An Important Cause of Temporal Headache in Patients Unlikely to Have Giant Cell Arteritis.

Temporal headache often results in an Ophthalmology referral to rule out giant cell arteritis (GCA). When clinical suspicion of GCA is low, alternative diagnoses should be considered. Temporomandibular disorder (TMD) commonly causes a temporal headache.

Volume alterations of brainstem subregions in migraine with aura.

The brainstem plays a significant role in migraine pathogenesis, but a relationship between volume alterations of brainstem subregions and migraine aura characteristics has not been sufficiently investigated. The aim of this study is to compare the volume of the brainstem, and its subregions, between patients with a migraine with aura (MwA) and healthy controls (HC), and also to correlate characte...

Abnormal visuo-vestibular interactions in vestibular migraine: a cross sectional study.

Vestibular migraine is among the commonest causes of episodic vertigo. Chronically, patients with vestibular migraine develop abnormal responsiveness to both vestibular and visual stimuli characterized by heightened self-motion sensitivity and visually-induced dizziness. Yet, the neural mechanisms mediating such symptoms remain unknown. We postulate that such symptoms are attributable to impaired ...

Striatal spreading depolarization: Possible implication in levodopa-induced dyskinetic-like behavior.

Spreading depolarization (SD) is a transient self-propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Park...

Efficacy of Botulinum Toxin in Tension-Type Headaches: A Systematic Review of the Literature.

Botulinum toxin is approved to treat chronic migraine and has shown significant benefit in refractory cases. Due to its effect on pain by sensory modulation there may also be efficacy in its use in chronic tension-type headaches (CTTH).

Evaluation and Management of the Emergency Department Headache.

The acute headache in the emergency department (ED) poses a diagnostic dilemma that may overwhelm providers attempting to weigh the cost of advanced workups against the risk of missing serious pathology. While the majority of headache concerns are benign primary headache disorders, identifying life-threatening secondary causes of headache-which may be broadly categorized into structural, infectiou...

Migraine: Stigma in Society.

Migraine is a prevalent disease with a substantial socioeconomic impact. However, stigma affects social attitude toward migraine, accruing additional burden on individuals with migraine and isolating them from a society that should be supporting them. PURPOSE OF THIS REVIEW: This review will discuss the following concepts: (1) the emergence of stigma toward migraine and its impact on medical care;...

Lumbar epidural blood patch: effectiveness on orthostatic headache and MRI predictive factors in 101 consecutive patients affected by spontaneous intracranial hypotension.

OBJECTIVEAlthough epidural blood patch (EBP) is considered the gold-standard treatment for drug-resistant orthostatic headache in spontaneous intracranial hypotension (SIH), no clear evidence exists regarding the best administration method of this technique (blind vs target procedures). The aim of this study was to assess the long-term efficacy of blind lumbar EBP and predictors on preoperative MR...

Relating Photophobia, Visual Aura, and Visual Triggers of Headache and Migraine.

This study investigated a potential association between visual factors and symptoms related to migraine. It was predicted that photophobia and visual aura would be positively associated with interictal light sensitivity and visual headache triggers (flicker, glare, and eyestrain), and that these 2 visual symptoms would also be associated.

The Spectrum of Vestibular Migraine: Clinical Features, Triggers, and Examination Findings.

To assess the ictal symptoms, interictal symptoms, psychiatric comorbidities, and interictal neuro-otologic examination findings in vestibular migraine (VM).

Substantial pain burden in frequency, intensity, interference and chronicity among children and adults with neurofibromatosis Type 1.

Tumor growths, migraine headaches, and other health-related complications reported in patients with neurofibromatosis type 1 (NF1) are often associated with pain. Thus, this study sought to describe and quantify the pain experience in children and young adults with NF1. Surveys were administered to 49 participants (28 children and 21 adults), ages 8 through 40 years. The survey included the Nume...

Treatment of migraine in a patient with epilepsy.

Epilepsy and migraine often occur concomitantly in the same patient. The cause may be found in the similar genetic and pathophysiological background of the two diseases that is manifested by an excessive tendency towards neuronal hyperexcitation. Migraine concomitant with epilepsy increases the risk of the patient developing drug-resistant epilepsy, depression and anxiety disorders, as well as sig...

A Qualitative Study to Assess the Impact of Iatrogenic Trigeminal Nerve Injury.

To deepen knowledge of the impact of iatrogenic trigeminal nerve injury on dental patients.

Intraoral Administration of Botulinum Toxin for Continuous Dentoalveolar Neuropathic Pain: A Case Series.

To examine the analgesic effect, safety, and tolerability of intraoral administration of onabotulinum toxin A (BoNT/A) in patients suffering from intractable continuous dentoalveolar neuropathic pain.

Long-term Low-Dose Sucrose May Prevent Migraine: Two Double-Blinded Randomized Controlled Pilot Trials.

To evaluate the efficacy of sucrose in the prevention of migraine attacks.

Iron deposition in periaqueductal gray matter as a potential biomarker for chronic migraine.

To study iron deposition in red nucleus (RN), globus pallidus (GP), and periaqueductal gray matter (PAG) as a potential biomarker of chronic migraine (CM) and its association with levels of biomarkers related to migraine pathophysiology.

CGRP antibodies for migraine prevention - new kids on the block.

Withdrawal from acute medication normalises short-term cortical synaptic potentiation in medication overuse headache.

To study the effects of a standard acute medication withdrawal program on short-term cortical plasticity mechanisms in patients with medication overuse headache (MOH).

Treatment of Medication Overuse Headache - a review.

Medication overuse headache (MOH) is the most prevalent chronic headache disorder with a prevalence between 1-2% worldwide. The disease has been acknowledged for almost 30 years, yet experts still disagree on how best to treat MOH. By performing a search in PubMed on the terms "medication overuse headache", "analgesics abuse headache", "rebound headache", "drug induced headache", and "headache AND...

Points & Pearls: Evaluation and management of life-threatening headaches in the emergency department

Headache is the fourth most common reason for emergency department encounters, accounting for 3% of all visits in the United States. Though troublesome, 90% are relatively benign primary headaches --migraine, tension, and cluster headaches. The other 10% are secondary headaches, caused by separate underlying processes, with vascular, infectious, or traumatic etiologies, and they are potentially li...

Calculated Decisions: Ottawa Subarachnoid Hemorrhage Rule

The Ottawa subarachnoid hemorrhage rule is used to rule out subarachnoid hemorrhage in patients with headache.

Virus load and clinical features during the acute phase of Chikungunya infection in children.

Chikungunya virus (CHIKV) infection is a long known mosquito-borne disease that is associated with severe morbidity, characterized by fever, headache, rashes, joint pain, and myalgia. It is believed that virus load has relation with severity of clinical features.

Impact of early headache neuroimaging on time to malignant brain tumor diagnosis: A retrospective cohort study.

Neuroimaging for headaches is both common and costly. While the costs are well quantified, little is known about the benefit in terms of diagnosing pathology. Our objective was to determine the role of early neuroimaging in the identification of malignant brain tumors in individuals presenting to healthcare providers with headaches.

The Treatment of Trigeminal Autonomic Cephalalgias: An Overview.

Trigeminal autonomic cephalalgias (TACs) are primary headaches that include cluster headache (CH), paroxysmal hemicrania (PH), and short-lasting unilateral neuralgiform headache attacks (SUNHAs) with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA). Hemicrania continua (HC) is another form that has been ascribed to TACs for clinical and pathophysiologic reasons. Clus...

Role of Link N in Modulating Inflammatory Conditions.

To elucidate the role of Link N in regulating inflammatory molecules from human mesenchymal stem cells (hMSCs) under interleukin (IL)-1β stimulation in vitro and under Complete Freund's Adjuvant (CFA)-induced arthritis of the temporomandibular joint (TMJ) in vivo.

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