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Heart Failure Research

00:59 EST 17th February 2019 | BioPortfolio

Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth.

Neuronal polarization depends on the interaction of intracellular chemical and mechanical activities in which the cytoplasmic protein, talin, plays a pivotal role during neurite growth. To better understand the mechanism underlying talin function in neuronal polarization, we overexpressed several truncated forms of talin and found that the presence of the rod domain within the overexpressed talin ...

Underlying Psychophysiology of Dysregulation: Resting Heart Rate and Heart Rate Reactivity in Relation to Childhood Dysregulation.

High co-occurrence of externalizing and internalizing problems may underlie inconsistent findings regarding the relation between heart rate and psychopathology. In this study, heart rate measures are examined in relation to a general dysregulation profile, studied from both a variable- and person-centered approach.

Heart Rate as a Biomarker for Co-Occurring Externalizing and Internalizing Problems.

Associations Among Caregiver Feeding Practices and Blood Pressure in African American Adolescents: The Jackson Heart KIDS Study.

Caregiver feeding practices have been linked to youth health outcomes. The present study examined associations among caregiver feeding practices and blood pressure in 212 African American adolescents via the Child Feeding Practices Questionnaire. Results revealed a positive association between caregivers' concern about their child's weight and diastolic blood pressure, which was more acute for old...

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria.

Sepsis-3 defines organ dysfunction as an increase in the Sequential Organ Failure Assessment score by greater than or equal to 2 points. However, some Sequential Organ Failure Assessment score components are not routinely recorded in all hospitals' electronic health record systems, limiting its utility for wide-scale sepsis surveillance. The Centers for Disease Control and Prevention recently rele...

Blood Pressure Covariance Not Accounted for in Angiotensin II for the Treatment of High-Output Shock 3 Subgroup Analysis.

Comparison of two portable clinical analyzers to one stationary analyzer for the determination of blood gas partial pressures and blood electrolyte concentrations in horses.

Portable blood gas analyzers are used to facilitate diagnosis and treatment of disorders related to disturbances of acid-base and electrolyte balance in the ambulatory care of equine patients. The aim of this study was to determine whether 2 portable analyzers produce results in agreement with a stationary analyzer. Blood samples from 23 horses hospitalized for various medical reasons were include...

Renal function stratified dose comparisons of eplerenone versus placebo in the EMPHASIS-HF trial.

Current heart failure guidelines recommend target eplerenone dose of 50 mg/day. We have examined the effect of different eplerenone doses based on pre-specified renal function stratification in the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF).

Implementing Reverse Phase Protein Array profiling as a sensitive method for the early pre-clinical detection of off-target toxicities associated with Sunitinib Malate.

The tyrosine kinase inhibitor (TKI) sunitinib is a multi-targeted agent approved across multiple cancer indications. Nevertheless, since approval, data has emerged to describe a worrisome side effect profile including hypertension, hand-foot syndrome, fatigue, diarrhoea, mucositis, proteinuria and (rarely) congestive heart failure. It has been hypothesised that the observed multi-parameter toxicit...

The prevalence of pressure ulcers in community-dwelling older adults: A study in an Indonesian city.

The objectives of this study were to investigate the prevalence and the characteristics of pressure ulcers (PU) in community-dwelling older adults in Indonesia, including specific characteristics of the PU patients and their use of formal and informal care. A cross-sectional design was used for the study, with 325 participants aged 60 years or older, randomly chosen from the general community. T...

Transplanting hepatitis C virus-infected hearts into uninfected recipients: A single-arm trial.

The advent of direct-acting antiviral therapy for hepatitis C virus (HCV) has generated tremendous interest in transplanting organs from HCV-infected donors. We conducted a single-arm trial of orthotopic heart transplantation (OHT) from HCV-infected donors into uninfected recipients, followed by elbasvir/grazoprevir treatment after recipient HCV was first detected (NCT03146741; sponsor: Merck). We...

Towards second generation cardiomyogenic and anti-cardiofibrotic 1,4-dihydropyridine-class of TGFβ inhibitors.

Innovative therapeutic modalities for pharmacological intervention of TGFβ-dependent diseases are of great value. b-Annelated 1,4-dihydropyridines (DHPs) might be such a class as they induce TGFβ receptor type-II degradation. However, intrinsic drawbacks are associated with this compound class and were systematically addressed in the presented study. It was possible to install polar functionalit...

Serum values of cytokines in patients with ischemic heart disease and arterial hypertension.

The studied levels of cytokines (levels of Pro-inflammatory cytokine - interleukin-1β, anti-inflammatory cytokine - interleukin-10, CD40 ligand (CD40L)) in patients with arterial hypertension and ischemic heart disease. Indicators of Pro-inflammatory cytokine - interleukin-1β and anti-inflammatory cytokine - interleukin-10 were significantly increased in patients with arterial hypertension and i...

Microflora of peripheral blood obtained from patients with infective endocarditis.

Infective endocarditis is a serious inflammatory disease associated with damage of heart valves and other parts of endocardium. This study included 91 patients with a confirmed diagnosis of «infectious endocarditis» and hospitalized at the Research Institute of Complex Problems of Cardiovascular Disease (Kemerovo, Russia) from 2010 to 2015. The determination of the spectrum of microorganisms in ...

All MoS Based Large Area, Skin-Attachable Active-Matrix Tactile Sensor.

Large-area, ultra-thin flexible tactile sensors with conformal adherence are becoming crucial for advances in wearable electronics, electronic skins and bio-robotics. However, normal passive tactile sensors suffer from high crosstalk, resulting in inaccurate sensing, which consequently, limits their use in such advanced applications. Active-matrix driven tactile sensors could potentially overcome ...

Thrombelastography-Directed Transfusion in Cardiac Surgery: Impact on Postoperative Outcomes.

Transfusion of allogenic blood products is associated with significant morbidity and increased risk of mortality. Thrombelastography (TEG) to direct transfusion management during and immediately following cardiothoracic surgery reduced blood product usage in our institution. The goal of this study was to quantify the impact of TEG on postoperative outcomes.

Organ Failure due to Systemic Injury in Acute Pancreatitis.

Acute pancreatitis may be associated with both local and systemic complications. Systemic injury manifests in the form of organ failure which is seen in approximately 20% of all cases of acute pancreatitis and defines 'severe acute pancreatitis'. Organ failure typically develops early in the course of acute pancreatitis, but may also develop later due to infected pancreatic necrosis induced sepsis...

Activation of the calcium-sensing receptor in human valvular interstitial cells promotes calcification.

Calcific aortic valve disease (CAVD) is the most common heart valve disease in western countries. It has been reported that activation of the calcium-sensing receptor(CaSR) expressed by vascular smooth muscle cells prevents vascular calcification. However, to date, the CaSR's expression and function in cardiac valves have not been studied. The present study sought to evaluate the presence of the C...

Regulation of cardiac transcription by thyroid hormone and Med13.

Thyroid hormone (TH) is a key regulator of transcriptional homeostasis in the heart. While hypothyroidism is known to result in adverse cardiac effects, the molecular mechanisms that modulate TH signaling are not completely understood. Mediator is a multiprotein complex that coordinates signal-dependent transcription factors with the basal transcriptional machinery to regulate gene expression. Med...

National Outcomes in Hospitalized Patients with Cancer and Comorbid Heart Failure.

Heart failure (HF) and cancer are a significant cause of morbidity and mortality in the US. Due to overlapping risk factors, these two conditions often coexist. We sought to describe the national burden of HF for hospitalized patients with cancer. We identified adults admitted with a primary oncologic diagnosis in 2014 included in the National Inpatient Sample (NIS). Patient hospitalizations were ...

(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease.

The (pro)renin receptor [(P)RR)] is involved in the activation of local renin-angiotensin system and subsequent development of cardiovascular disease. We investigated the therapeutic effect of a (P)RR blocker, handle region peptide (HRP), on chronic kidney disease (CKD)-associated heart failure.

Eyeing autonomic dysregulation in heart failure.

The 50 Year Anniversary of the His Bundle Recording and Pacing in Clinical Medicine.

Calcium Dobesilate and Micro-vascular diseases.

Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement lead to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate Drug (CAD) is an established vasoactive and angioprotective drug th...

Spectral fingerprinting of decellularized heart valve scaffolds.

Decellularized heart valves hold promise for their use as bioscaffolds in cardiovascular surgery. Quality assessment of heart valves after decellularization processing and/or storage is time consuming and destructive. Fourier transform infrared spectroscopy (FTIR) allows rapid non-invasive assessment of biomolecular structures in tissues. In this study, IR-spectra taken from different layers of th...

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