Hepatology Research

02:18 EDT 19th August 2018 | BioPortfolio

Mixed Hepatocelllar-Cholangiocarcinoma: Is it Time to Rethink Consideration for Liver Transplantation?

Recognition of a mixed hepatocellular-cholangiocarcinoma (HCC-CCA) in a candidate is generally considered a contraindication to liver transplantation (LT) due to a perception of poor posttransplant survival and high recurrence rates. Due to the relative rarity of these tumors and a lack of widely accepted and consistent diagnostic criteria, there is little published data to guide transplant consid...

Need for Caudate duct classification: God is in the detail and so is the Devil!

Caudate duct classification is important not only in understanding the complex hilar anatomy intraoperatively but also in post-operative decision making in management of biliary complications. This article is protected by copyright. All rights reserved.

Multinational validation of the AJCC 8 edition pancreatic cancer staging system in a pancreas head cancer cohort.

The aim was to compare the 7 and 8 editions of the AJCC staging system for pancreas head cancer and to validate the 8 edition using three multinational tertiary center data.

Fluorescence based Nano Oxygen Particle (FNOP) for Spatiometric Monitoring of Cell Physiological Conditions.

Closed-loop artificial pancreas systems have recently been proposed as a solution for treating stage I diabetes by reproducing the function of the pancreas. However, there are many unresolved issues associated with their development, including monitoring and controlling oxygen, immune responses and the optimization of glucose. All of which need to be monitored and controlled to produce an efficien...

Testing for AFP in combination with ultrasound improves early liver cancer detection.

Periodontal Therapy Favorably Modulates the Oral-Gut-Hepatic Axis in Cirrhosis.

Cirrhosis is associated with a systemic pro-inflammatory milieu, endotoxemia and gut dysbiosis. The oral cavity could be an additional source of inflammation. We aimed to determine the effect of periodontal therapy in cirrhosis through evaluating endotoxemia, inflammation, cognition and quality of life (QOL). Age-matched cirrhotic/non-cirrhotic subjects exhibiting chronic gingivitis and/or mild/mo...

Robotic Surgery of the Liver and Biliary Tract.

The laparoscopic methods for major abdominal surgery are gaining increasing acceptance worldwide. Despite its relatively recent introduction in clinical practice, robotics has been accepted as an effective option to perform high-demanding procedures such as those required in hepatobiliary surgery. Some potential advantages over conventional laparoscopy have been suggested, but its actual role in c...

Giant hepatic hemangioma, an uncommon presentation of a frequent disease.

Hepatic hemangiomas, also referred to as cavernous hemangiomas, are the most common benign mesenchymal hepatic tumors. They are often solitary, small lesions that have an excellent safety-prognosis and were commonly incidentally detected. Hepatic hemangiomas are frequently asymptomatic, although symptoms are more likely in those lesions larger than 5 cm also referred to as giant hemangiomas. We pr...

Endoscopic-radiologic rendezvous for biliary obstruction management. Case report and literature review.

Biliary obstruction of different origin is a common clinical problem, with significant impact on the patients quality of life and poses a permanent risk of cholangitis. The management of these patients has evolved over time, makes collection of various technological developments and involve clinicians, surgeons, gastroenterologists, and interventional radiologists. Were port four cases of biliary ...

Fatal bacteremia as a complication of hepatic abscess due to Achromobacter xylosoxidans: presentation as a complication in a patient with diabetes mellitus and liver cirrhosis.

Performances of Creatinine-Based GFR Estimating Equations in Simultaneous Pancreas-Kidney Transplant Recipients: a single center cohort study.

Estimating glomerular filtration rate (GFR) is important for clinical management and research studies in simultaneous pancreas-kidney transplantation (SPK) recipients. No study has specifically investigated the reliability of recent creatinine-based GFR estimating equations in this singular population. We assessed the performances of CKD-EPI, MDRD, Schwartz-2009, Schwartz-Lyon, Lund-Malmo and Full...

Difficulty scoring system in laparoscopic distal pancreatectomy.

Several factors affect the level of difficulty of laparoscopic distal pancreatectomy (LDP). The purpose of this study was to develop a difficulty scoring (DS) system to quantify the degree of difficulty in LDP.

Mechanism of TRIM25 mediated ubiquitination of metastasis associated protein (MTA) 1 in normal liver cells.

Ninety percent of all cancer related deaths happen due to metastatic progression. One important protein facilitating metastatic progression in hepatocellular carcinoma (HCC) is the metastasis associated 1 protein (MTA-1). We have earlier shown that in the context of HCC and normal liver cell lines, HuH6 and THLE-2, respectively. MTA-1 protein is actively stabilized in HCC cell lines and actively d...

CHST3 and CHST13 polymorphisms as predictors of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension.

Bosentan, an endothelin receptor antagonist, has been widely used as a first-line drug for the treatment of pulmonary arterial hypertension (PAH). In addition, bosentan is approved for patients with digital ulcers related to systemic sclerosis. Liver dysfunction is a major adverse effect of bosentan and may lead to discontinuation of therapy. The purpose of this study was to identify genomic bioma...

Premna integrifolia ameliorates cyclophosphamide-induced hepatotoxicity by modulation of oxidative stress and apoptosis.

The present study was designed to evaluate the ameliorative effect of ethyl acetate extract of Premna integrifolia L. (EAEPI) leaves in cyclophosphamide (CP)-induced hepatic injury in mice. Mice were intoxicated with CP (200 mg/kg b. wt., i.p.) for 5 weeks or EAEPI (400 and 600 mg/kg b. wt., orally) in combination with CP. The results demonstrated that EAEPI exerts protective effect against CP...

Targeting NLRP3 inflammasome via acetylsalicylic acid: Role in suppressing hepatic dysfunction and insulin resistance induced by atorvastatin in naïve versus alcoholic liver in rats.

NLRP3 inflammasome is described in many pathological conditions and is also involved in drug induced liver injury.

Preliminary screening and functional analysis of circular RNAs associated with hepatic stellate cell activation.

To screen for circular RNAs (circRNAs) that are associated with the activation of hepatic stellate cell (HSC) by monitoring changes in liver circRNA expression in a model of liver fibrosis.

Two intrauterine programming mechanisms of adult hypercholesterolemia induced by prenatal nicotine exposure in male offspring rats.

Epidemiologic studies showed that low birth weight is associated with high cholesterol and an increased risk of cardiovascular diseases in adulthood. This study aimed to elucidate the intrauterine programming mechanisms of adult hypercholesterolemia. The results showed that prenatal nicotine exposure (PNE) caused intrauterine growth retardation and hypercholesterolemia in male adult offspring rats...

Analysis of survival and prognostic factors in treatment of hepatocellular carcinoma in Spanish patients with drug-eluting bead transarterial chemoembolization.

Drug-eluting bead transarterial chemoembolization (DEB-TACE) improves the survival of patients with hepatocellular carcinoma (HCC), intermediate stage [i.e. Barcelona Clinic Liver Cancer-B (BCLC-B)]. The aim of our study was to analyse the overall survival (OS) and prognostic factors of patients with HCC treated with DEB-TACE.

Quantifying Lymph Nodes During Lymph Node Transplantation: The Role of Intraoperative Ultrasound.

Quantifying lymph nodes in vascularized lymph node transfer (VLNT) has been performed using preoperative percutaneous ultrasound. The higher resolution and accuracy of intraoperative ultrasound (IOUS) over transcutaneous ultrasound has been demonstrated in the radiology literature for the identification and characterization of finer structures including hepatic lesions, pancreatic lesions, and bil...

Protocol Duodenal Graft Biopsies Aid Pancreas Graft Surveillance.

Histological evaluation of the pancreas graft is usually done on demand resulting in significant delays. This analysis reports on endoscopic protocol duodenal graft biopsies at regular intervals to determine feasibility, safety and monitoring benefits.

Clinical Relevance of a Balance Training Program on Liver Transplant Patients. A Randomized Controlled Trial.

Although some studies have reported significant improvements in physical function and strength after training programs on Liver Transplant (LT) recipients, there is a lack of knowledge on how it affects in static and dynamic balance, being an important part of these participants' tasks development. The aim of the study was to determine the effects of a 6-month multicomponent circuit training progr...

Tree of death: The role of fossils in resolving the overall pattern of plant phylogeny.

C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis.

Our previous study revealed that mice transgenic for endothelial-cell-specific overexpression of CNP (E-CNP Tg mice) are protected against the increased fat weight, inflammation, and insulin resistance associated with high-fat diet (HFD)-induced obesity. In addition, E-CNP overexpression prevented abnormal lipid profiles and metabolism and blocked inflammation in the livers of HFD-fed mice. Becaus...

Proteomic approach to identify molecular signatures during experimental hepatic fibrosis and resveratrol supplementation.

We document the changes in sera and liver proteome during experimental hepatic fibrosis (HF) and its protection by resveratrol (Rsvtrl) in rats. HF was induced by N'-Nitrosodimethylamine (NDMA) administration thrice a week for 21-days. Compared to the control group, significant (P 2 fold) in their expression. Out of them, two signatures have not so far

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