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Immunology Research

16:26 EST 18th December 2018 | BioPortfolio

The efficacy and safety of fluticasone salmeterol compared to fluticasone in children younger than four years of age.

Fluticasone propionate 50 μg/salmeterol xinafoate 25 μg (FP/SAL) is widely used in adults and children with asthma but there is sparse information on its use in very young children.

New insights into the pathophysiology of IgG4-related disease and markers of disease activity.

Recently, IgG4-related disease (IgG4-RD) has become a well-recognized clinical entity, although its causes are still not well understood. The pathophysiology of IgG4-RD has been reported from a variety of aspects. Areas covered: In this review, we outline a number of recent advances in our understanding of the pathogenesis of IgG4-RD, divided according to acquired immunology and innate immunology ...

Editorial introductions.

Physiologic colonic fluorine-18-fluorodeoxyglucose uptake may predict response to immunotherapy in patients with metastatic melanoma.

The gut microbiota impacts response to immunotherapy in cancer patients. We sought to evaluate the role of physiologic colonic fluorine-18-fluorodeoxyglucose (F-FDG) uptake, a test that was recently shown to reflect colonic bacterial load, as a possible predictor for response to immunotherapy. We carried out a retrospective study in metastatic melanoma patients who received the immune checkpoint i...

Cytokine release syndrome as an important differential diagnosis of severe skin toxicity with organ damage during switch from immunotherapy to targeted therapy in metastatic melanoma.

Goose MAVS functions in RIG-I-mediated IFN-β signaling activation.

Mitochondrial antiviral-signaling protein (MAVS) is an essential adaptor protein in retinoic acid-inducible gene I (RIG-I)-mediated antiviral innate immunity in mammals. In this study, the goose MAVS gene (goMAVS) was identified. The 2,019 bp-long goMAVS exhibits 96.2% amino acid similarity compared to the predicted goMAVS. Quantitative real-time polymerase chain reactions showed that goMAVS mRNA ...

Mast Cell Granules: Modulating adaptive immune response remotely.

Molecular cloning and expression analysis of coagulation factor VIII and plasminogen involved in immune response to GCRV, and immunity activity comparison of grass carp Ctenopharyngodon idella with different viral resistance.

The grass carp reovirus (GCRV) has been shown to cause lethal infections in the grass carp Ctenopharyngodon idella (C. idella). In order to investigate the immune response to GCRV infection, the full-length cDNA sequences of coagulation factor VIII (CiFVIII) and plasminogen (CiPLG) from C. idella were cloned and their involvement in the immune response was studied. The immunity factor levels in C....

Aquatic animal viruses mediated immune evasion in their host.

Viruses are important and lethal pathogens that hamper aquatic animals. The result of the battle between host and virus would determine the occurrence of diseases. The host will fight against virus infection with various responses such as innate immunity, adaptive immunity, apoptosis, and so on. On the other hand, the virus also develops numerous strategies such as immune evasion to antagonize hos...

The Relationship of Exhaled Nitric Oxide with Ethnicity and Gender in Rural Georgia YouthAuthors.

Associations of urban greenness with asthma and respiratory symptoms in Mexican American children.

Effective Effectors: How T cells Access and Infiltrate the Central nervous System.

Several Phase II and III clinical trials have demonstrated that immunotherapy can induce objective responses in otherwise refractory malignancies in tumors outside the central nervous system. In large part, effector T cells mediate much of the antitumor efficacy in these trials, and potent antitumor T cells can be generated through vaccination, immune checkpoint blockade, adoptive transfer, and ge...

Real-World Attitudes Among Allergists/Immunologists Regarding Oral Immunotherapy and Preferred Terminology.

Comparison of International Systemic Adverse Reactions due to Allergen Immunotherapy.

Several classifications of systemic adverse reactions (SAR) during allergen immunotherapy (AIT) have been proposed but the comparison of their usefulness in daily clinical practice is lacking.

Drugs of porcine origin - a risk for patients with α-Gal syndrome?

Differentiation of angioimmunoblastic T-cell lymphoma from DRESS syndrome.

The Journal of Allergy and Clinical Immunology: In Practice 2018 Highlights.

A large number of clinically impactful studies and reviews were published in this Journal in 2018. This article provides highlights of the original research published in 2018 issues of JACI: In Practice on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, eosinophilic disorders, food allergy, immune deficiency, rhinitis/upper respiratory disease, and urticaria/angioedema. Within each ...

Harmonization of Terminology for Tolerated and Reactive Dose in Food Allergy Immunotherapy.

Currently, there is no FDA-approved therapy for food allergy. Several new potential treatments are under investigation, including food allergen immunotherapy via various routes of administration, such as oral immunotherapy, epicutaneous therapy, subcutaneous immunotherapy, and sublingual immunotherapy. The double-blind, placebo-controlled food challenge has traditionally been used for diagnostic p...

Corrigendum to "Critical role for Salmonella effector SopB in regulating inflammasome activation" Mol. Immunol. 90 (2017) 280-286.

Immunotherapy in acute myeloid leukemia and myelodysplastic syndromes: The dawn of a new era?

Immunotherapy has revolutionized therapy in both solid and liquid malignancies. The ability to cure acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) with an allogeneic hematopoietic stem cell transplant (HSCT) is proof of concept for the application of immunotherapy in AML and MDS. However, outside of HSCT, only the anti-CD33 antibody drug conjugate gemtuzumab ozogamicin is current...

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Oral exposure to mite allergens: Sensitizer or tolerogenic?

Oral vaccination with influenza hemagglutinin combined with human pulmonary surfactant-mimicking synthetic adjuvant SF-10 induces efficient local and systemic immunity compared with nasal and subcutaneous vaccination and provides protective immunity in mice.

We reported previously that a synthetic mucosal adjuvant SF-10, which mimics human pulmonary surfactant, delivers antigen to mucosal dendritic cells in the nasal cavity and promotes induction of humoral and cellular immunity. The aim of the present study was to determine the effects of oral administration of antigen combined with SF-10 (antigen-SF-10) on systemic and local immunity. Oral administr...

Rational combination immunotherapeutic approaches for effective cancer treatment.

Immunotherapy is an important mode of cancer treatment. Over the past decades, immunotherapy has improved the clinical outcome for cancer patients. However, in many cases, mutations in cancer cells, lack of selectivity, insufficiency of tumor-reactive T cells, and host immunosuppression limit the clinical benefit of immunotherapy. Combination approaches in immunotherapy may overcome these obstacle...

Immunotherapy Advances in Urothelial Carcinoma.

Checkpoint inhibitors have monumentally transformed the treatment of metastatic urothelial carcinoma. While the efficacy and safety of the different agents are similar in platinum-refractory metastatic urothelial carcinoma, pembrolizumab is the only agent that was superior to chemotherapy in a randomized phase III trial. Pembrolizumab and atezolizumab are also approved as first-line therapies in c...

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