Infectious-diseases Research

08:29 EDT 24th May 2018 | BioPortfolio

Monomicrobial Klebsiella pneumoniae necrotizing fasciitis - an emerging life threatening entity.

Necrotizing fasciitis (NF) although rare, is a potentially fatal infection. Majority of cases being polymicrobial; a recent surge in monomicrobial NF caused by Klebsiella pneumoniae (KP-NF) has been reported. KP-NF recently accounted for an average of 16% amongst all pathogens with highest mortality rate of 60%. This review discusses the important aspects of KP-NF with additional note on implicati...

Human pegivirus persistence in the human blood virome after allogeneic haematopoietic stem cell transplantation.

As commensal viruses are defined by the immunological tolerance afforded to them, any immunomodulation, such as is received during haematopoietic stem cell transplantation, may shift the demarcation between innocuous viral resident and disease-causing pathogen.

Understanding the microbiome of diabetic foot osteomyelitis: insights from molecular and microscopic approaches.

Rigorous visual evidence on whether or not biofilms are involved in diabetic foot osteomyelitis (DFO) is lacking. We employed a suite of molecular and microscopic approaches to investigate the microbiome, and phenotypic state of microorganisms involved in DFO.

Diagnosis of bloodstream infections from positive blood cultures and directly from blood samples: recent developments in molecular approaches.

Bloodstream infections are a major cause of death with increasing incidence and severity. Blood cultures are still the gold standard for microbiological diagnosis, but are rather slow. Molecular methods can be used as add-on complementary assays. They can be useful to speed up microbial identification and to predict antimicrobial susceptibility, applied to direct blood samples or positive blood cu...

Invasive Mold Disease in Hematologic Patients: Comparison between Fusariosis and Aspergillosis.

To compare the epidemiology, clinical presentation, diagnosis, treatment and outcome of hematologic patients with invasive aspergillosis (IA) or invasive fusariosis (IF).

Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) Study of Respiratory Syncytial Virus-Associated Deaths in Pediatric Patients in Canada: 2003 to 2013.

Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in children. Mortality rates in previously healthy children hospitalized with RSV are < 0.5%, but up to 37% in patients with underlying medical conditions. The objective of this study was to characterize factors associated with deaths among children hospitalized with RSV infection in Canadian pediatric centres.

Mycoplasma Pneumoniae among Children Hospitalized with Community-acquired Pneumonia.

The burden and epidemiology of Mycoplasma pneumoniae (Mp) among U.S. children (

Frailty, Neurocognitive Impairment, or Both in Predicting Poor Health Outcomes Among Adults Living with HIV.

Neurocognitive impairment (NCI) is strongly associated with frailty in people living with HIV (PLWH); the overlap of frailty and NCI, and the impact on health outcomes in PLWH is unknown.

Reply to Garcia-Granja, et al.

Molecular epidemiology of Candida auris in Colombia reveals a highly-related, country-wide colonization with regional patterns in Amphotericin B resistance.

Candida auris is a multidrug-resistant yeast associated with hospital outbreaks worldwide. During 2015-2016, multiple outbreaks were reported in Colombia. We aimed to understand the extent of contamination in healthcare settings and to characterize the molecular epidemiology of C. auris in Colombia.

Rabies Pre-exposure Prophylaxis: Application of Updated WHO Position to Travelers.

Clinical implications of asymptomatic Plasmodium falciparum infections in Malawi.

Asymptomatic Plasmodium falciparum infections are common in Malawi, however, the implications of these infections for the burden of malaria illness are unknown. Whether asymptomatic infections eventually progress to malaria illness, persist without causing symptoms, or clear spontaneously remains undetermined. We identified asymptomatic infections and evaluated the associations between persistent ...

Control of Multidrug-Resistant Pseudomonas aeruginosa in Allogeneic Hematopoietic Stem Cell Transplant Recipients by a Novel Bundle Including Remodeling of Sanitary and Water Supply Systems.

Effects of Immunonutrition in Advanced HIV Disease: a Randomized Placebo Controlled Clinical Trial (Promaltia Study).

While nutritional interventions with prebiotics and probiotics seem to exert immunological effects, their clinical implications in HIV-infected subjects initiating ART at advanced HIV disease remain unclear.

Reply to Buonfrate and Bisoffi.

Risk Factors for Group A Streptococcus Colonization During an Outbreak among People Experiencing Homelessness in Anchorage, Alaska, 2017.

We identified risk factors for any emm-type group A streptococcal (GAS) colonization while investigating an invasive emm26.3 GAS outbreak among people experiencing homelessness in Alaska. Risk factors included upper extremity skin breakdown, sleeping outdoors, sharing blankets, and infrequent tooth brushing. Our results may help guide control efforts in future outbreaks.

Risk Factors for Treatment Failure and Mortality among Hospitalised Patients with Complicated Urinary Tract Infection: A Multicentre Retrospective Cohort Study, RESCUING Study Group.

Complicated urinary tract infections (cUTIs) are responsible for a major share of all antibiotic consumption in hospitals. We aim to describe risk factors for treatment failure and mortality among hospitalised patients with cUTIs.

Is Ivermectin Ineffective for Strongyloidiasis?

Rotavirus Vaccination Is Associated with Reduced Seizure Hospitalization Risk Among Commercially Insured U.S. Children.

Rotavirus commonly causes diarrhea but can also cause seizures. Analysis of insurance claims for 1,773,295 US children with 2950 recorded seizures found that, compared to rotavirus-unvaccinated children, seizure hospitalization risk was reduced by 24% (95% confidence interval [CI], 13% - 33%) and 14% (95%CI, 0% - 26%) among fully and partially rotavirus-vaccinated children, respectively.

Mycoplasma pneumoniae as a Cause of Community-Acquired Pneumonia in Children.

Rabies Antibody Response after Booster Immunization: A Systematic Review and Meta-Analysis.

Although fatal once symptomatic, rabies is preventable by administration of pre- and post-exposure vaccines. International guidelines suggest life-long protection by a pre-exposure vaccination scheme followed by timely post-exposure vaccines. Rapidity and magnitude of the antibody recall response after booster inoculation are essential, as many people have been previously immunized a long time ago...

An Unusual Presentation of Murine Typhus and Mononucleosis.

A 20-year-old female presented to the emergency department complaining of fever, cough, and dyspnea after a recent camping trip. The patient remained ill appearing, persistently tachycardic and dyspneic despite nebulizer treatments, and fluids in the emergency department. She was admitted for observation and gradually improved over the next 4 d. Inpatient laboratory studies indicated acute Epstein...

Nutritionally Variant Streptococci infective endocarditis; a different view.

Comparison of C. difficile Stool Toxin Concentrations in Adults with Symptomatic Infection and Asymptomatic Carriage using an Ultrasensitive Quantitative Immunoassay.

We used an ultrasensitive, quantitative Single Molecule Array (Simoa) immunoassay to test whether concentrations of C. difficile toxins A and/or B in the stool of adult inpatients with CDI were higher than in asymptomatic carriers of toxinogenic C. difficile.

US Black Women and Human Immunodeficiency Virus Prevention: Time for New Approaches to Clinical Trials.

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