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Mental Health Clinical Trials

14:39 EST 15th December 2018 | BioPortfolio

Homeless Youth Study - Stepping Stone 2.0

Housing instability is both a cause and consequence of mental health problems. As such youth experiencing housing instability (e.g., homeless or marginally housed) have higher rates of mental health problems.Because of their circumstances, these youth also face significant barriers to mental health care and are therefore less likely to receive the treatment that they need. ...

Coordinating Access to Care for People Experiencing Homelessness (CATCH-FI)

Coordinating Access to Care for the Homeless (CATCH) initiative is a multidisciplinary brief intervention for homeless adults with mental health needs discharged from hospital in Toronto, Canada. The study aims to evaluate the effect of financial incentives in facilitating treatment engagement of homeless people with mental illness, as well as in improving health, health se...

Efficacy of a MBI Programme With or Without Virtual Reality Support to Reduce Stress in University Students

There is a growing concern about mental health problems of university students. Stress, anxiety, and depression are reported to be common in this population. For this reason, mindfulness training is becoming increasingly popular in university contexts. This randomized controlled trial (RCT) pretends to evaluate the efficacy of a mindfulness-based intervention (MBI) to reduc...

Defining the Sympathetic Skin Response of Migraineurs in the Facial Area

The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation, auditory stimulation and a mathematical challenge), and recording sympathetic skin response in the facial area.

High Frequency rTMS Treatment for Cognitive Impairments in Chronic Schizophrenia Patients

A randomized, double-blind sham-controlled trial of high frequency rTMS treatment for cognitive impairments in 120 chronic schizophrenia patients

Assessment of Medherent Medication Management Device and Adherence Platform

This study uses a stepped wedge designs to estimate the effect of using the Medherent Medication Management Device on medication adherence for a population of 150 individuals who are diagnosed with serious mental illness.

Mindfulness for Emerging Adults Experiencing Anxious and/or Depressive Symptoms

Emerging adults (EA; 18 to 29 years old) in Canada are among the age group with highest risk of developing mental health issues. Despite this, they experience especially long wait-times for mental health services. To date, there has been minimal research into developmentally appropriate treatment options for the EA population. Mindfulness-based interventions (MBIs) are emer...

Self-help Guided by Lay Providers for Anxiety in Older Adults

Few older adults receive treatment for Generalized Anxiety Disorder (GAD) despite a high prevalence in this population and significant associated health care costs. Although older adults generally prefer psychotherapy to medication for help with anxiety, face-to-face psychotherapy is difficult to access for many of them. Psychological guided self-help (GSH), which patients ...

A Stress Management and Resiliency Program for Adolescent and Young Adult Survivors

This research study aims to explore the feasibility and acceptability of an adapted resiliency group program, called the Relaxation Response Resiliency Program (3RP-AYA), to reduce stress and promote stress-management among adolescents and young adults who have completed treatment for cancer.

Combined Treatment of Prolonged Exposure and Pramipexole for Posttraumatic Stress Disorder and Depression

This pilot study aims to test the safety, feasibility, and initial efficacy of combined 10 week treatment of prolonged exposure (PE) and Pramipexole in patients with comorbid posttraumatic stress disorder (PTSD) and depression (MDD). Resting state functional connectivity (rsFC) will be assessed at baseline and en of treatment.

Exploring the Outcomes of System Supports for Youth With Mental Illness and/or Addictions and Their Families

This is a pilot study to assess the feasibility of a larger scale clinical trial of different methods of supporting families in finding mental health and/or addictions (MHA) services for youth.Youth with MHA issues and their families are particularly vulnerable in the MHA system, due to a lack of specialized support and complicated transitions between services. The potentia...

Vitamin D Supplementation in Patients With Depression

Groups (intervention group receives 50000 IU vitamin D and control group receives placebo) through a random allocation. After 8 weeks, blood sample will be collected from each participant. The studied indices (inflammatory (IL-1β, IL-6, hs-CRP), PTH, platelet serotonin, serum oxytocin, serum 25(OH) D, depression status and anthropometry indices) will be evaluated at beginn...

A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury

The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT) control condition, and to determine the rehabilitative utility of IOK for Veterans with PTSD. The first aim is to test whether IOK can help improve p...

Psychological Skills Group for Youth of Refugee and Immigrant Backgrounds

There are currently 28 million child refugees worldwide - approximately 1 in every 200 children on earth. To date, nearly one million forcibly displaced child migrants have been resettled in the United States. It is well documented that refugee and immigrant youth, especially forcibly displaced ethnic and cultural minority youth, present with alarmingly high rates of stress...

The Effects of Pregnancy Classes and Contributing Factors to Postpartum Depression

It is recommended by the American College of Obstetricians and Gynecologists' Committee on Obstetric Practice that all obstetricians screen each women for postpartum depression and anxiety with a validated instrument. Although much effort is made, the contributing factors still lack in the literature due to its multi-factorial nature and complexity. In addition, the effect...

Clinical Trial of Enhanced Measurement-Based Care (eMBC)

This feasibility study investigates the use of enhanced measurement-based care (eMBC) within routine medical treatment for patients with depression in an outpatient psychiatric setting. eMBC will be facilitated using an Internet-based application optimized for mobile devices, such as smartphones and tablets. The study investigates whether patients and their treating clinici...

Evaluation of A Mindfulness Resiliency Training Program for Refugees Living in Jordan

To estimate the efficacy of a structured, scalable and replicable psychosocial intervention targeting refugees living in Jordan, Amman who have been forced to flee their homes due to regional conflicts.

Ford Rumination and Mindfulness Merit

The investigators will acquire simultaneous EEG and fMRI data from veterans with depression and schizophrenia and mentally healthy veterans to assess early sensory responses, context updating, and responses to emotional images. Understanding how rumination affects engagement with the environment is the first step towards assessing its far-reaching cognitive and emotional co...

Targeting Physical Health in Schizophrenia: Physical Activity Can Enhance Life

Purpose: To develop and test the feasibility of an exercise intervention that combines group walking, activity tracking, and heart rate monitoring, and determine the effectiveness of this intervention on the physical and mental health for individuals with schizophrenia spectrum disorders. Participants: 14 individuals with schizophrenia spectrum disorders. Procedures...

Music-instruction Intervention for Treatment of Post-traumatic Stress Disorder

The purpose of this study was to examine the feasibility and potential effectiveness of an active, music-instruction intervention in improving psychological health and social functioning among Veterans suffering from moderate to severe Post-traumatic Stress Disorder (PTSD).

Enhanced Problem-Solving Training

Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom. It is also highly co-morbid with mental health conditions, such as post-traumatic stress disorder and depression. While mTBI alone is not typically thought to cause lasting deficits in personal functioning or cognitive abilities, Veterans with...

The Effects of Mental Practice Combined With Proprioceptive Neuromuscular Facilitation on Muscle Strength of Upper Limb and Hand Grip

The effects of mental practice combined with proprioceptive neuromuscular facilitation on muscle strength of upper limb and hand grip were measured in 30 healthy female students with right dominant hand, they were recruited from College of Applied Medical Sciences, Jazan University. Their age ranged from19 to 26 years old. Subjects were randomly assigned to either proprioce...

Cancer Patients in Clinical Trials and Their Relatives

Aims The aims of this study are: 1. To characterize patients' psychological well-being from the time they are referred to a phase I trial and determine risk factors for poor well-being. 2. To investigate perceived information, expectations and regret when a patient participate in a phase I trial. Materials and methods This study is a prospectiv...

Mindfulness and Self-Compassion in McGill University

Mental health issues are increasingly costly in Quebec. Given most psychological disorders occur before age 24, university-based interventions are appealing to prevent and treat mental illness, especially as rates of psychological distress have peaked among university students in our province. This at-risk population may benefit from new university-based programs, as academ...

Cranial Electrotherapy Stimulation in the Treatment of Posttraumatic Stress Disorder

This is a research study that will look at how well a treatment called Cranial Electrotherapy Stimulation (CES) works for patients who struggle with symptoms of Posttraumatic Stress Disorder. Cranial Electrotherapy Stimulation is delivered using a device called Alpha-Stim®. This is a safe, non-invasive treatment that applies a low-level pulsed electric current through the ...

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