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Mergers & Acquisitions Research

03:50 EDT 22nd October 2018 | BioPortfolio

The role of public health units in the delivery of HIV pre-exposure prophylaxis (PrEP).

Pre-exposure prophylaxis (PrEP) is an HIV prevention strategy involving the use of once daily antiretroviral medications to prevent HIV infection. Available research supports that PrEP, when used as prescribed, can prevent HIV transmission by upwards of 96%. Such findings have led to the development of research publications and guidelines supporting PrEP for individuals at high risk for HIV acquis...

Lateral geniculate nucleus volumetry at 3T and 7T: Four different optimized magnetic-resonance-imaging sequences evaluated against a 7T reference acquisition.

The lateral geniculate nucleus (LGN) is an essential nucleus of the visual pathway, occupying a small volume (60-160 mm) among the other thalamic nuclei. The reported LGN volumes vary greatly across studies due to technical limitations and due to methodological differences of volume assessment. Yet, structural and anatomical alterations in ophthalmologic and neurodegenerative pathologies can onl...

Facilitators to support the implementation of injury prevention training in youth handball: A concept mapping approach.

There is a need for research to identify effective implementation strategies for injury prevention training within real-world community sports. The aim of this ecological participatory study was to identify facilitators, among stakeholders at multiple levels, that could help injury prevention training become part of regular training routines in youth team handball. Concept mapping, a mixed-method ...

Trends in interorganizational transactions in personalized medicine development.

Personalized medicine is an innovative concept that allows patients with a validated companion diagnosis (CoDx) to receive treatment using the most suitable drug. Currently, a major movement in the pharmaceutical industry involves the integrated use of multiple resources from external sources. To ascertain preferable interorganizational collaborations and their suitable exits, we compared the rela...

Local collaborations for physical activity promotion: a network analysis.

This study aims to describe a local network for physical activity promotion and identify factors associated to collaboration or partnership ties between its actors. The study was carried out in a district of São Paulo, Brazil. Thirty-two actors responsible for policies, programs, and initiatives to promote physical activity within the district were interviewed from June to December 2012. Intervie...

ISBER and the Biobanking and Cohort Network (BCNet): A Strengthened Partnership.

Universal and language-specific predictors of early word reading in a foreign language: An analysis of the skills that underlie reading acquisition in three different orthographies.

A central question in the field of foreign language acquisition is whether the processes involved in reading development in a foreign language are universal or dependent on characteristics of the specific language involved. We investigated the impact of orthographic depth and writing system on word reading acquisition in a foreign orthography, by studying children who are proficient readers in the...

Using a sociomaterial approach to generate new insights into the nature of interprofessional collaboration: Findings from an inpatient medicine teaching unit.

Today's hospitals are burdened with patients who have complex health needs. This is readily apparent in an inpatient internal medicine setting. While important elements of effective interprofessional collaboration have been identified and trialled across clinical settings, their promise continues to be elusive. One reason may be that caring for patients requires understanding the size and complexi...

Interprofessional education at the meso level: taking the next step in IPE.

The downstream demand for professionals with competence in Interprofessional Collaboration (IPC) has contributed to the substantial growth in the upstream demand for interprofessional education (IPE). The majority of IPE programs focuses exclusively on direct care practitioners and seldom include those responsible for the administration and management of care. Unfortunately, complex reimbursement ...

Post mortem high resolution diffusion MRI for large specimen imaging at 11.7 Tesla with 3D segmented echo-planar imaging.

Diffusion weighted imaging (DWI) is the only in vivo technique allowing for the mapping of tissue fiber architecture. Post mortem DWI is an increasingly popular method, since longer acquisition times (compared to in vivo) allow higher spatial and angular resolutions to be achieved. However, DWI protocols must be adapted to post mortem tissue (e.g., tuning acquisition parameters to account for chan...

Stress as a context: Stress causes relapse of inhibited food seeking if it has been associated with prior food seeking.

Three experiments with rats explored the hypothesis that inhibited food-seeking can be reinstated by stress if stress has been part of the context of earlier food-seeking. In all experiments, rats first learned to lever press for sucrose pellets and then had the response inhibited through extinction (where responding no longer yielded sucrose pellets). In a final test, inhibited responding was tes...

Dynamic Light Scattering Analysis to Dissect Intermediates of SNARE-Mediated Membrane Fusion.

Dynamic light scattering (DLS) spectroscopy provides rapid information on the size distribution of a large number of particles in a mixture. Vesicle sizes change during the merger of lipid bilayers, and DLS analysis can provide rapid, accurate, and non-perturbative quantification of the size distribution of proteoliposomes in SNARE-dependent membrane fusion. In this chapter, we describe the method...

An In Vitro Assay of Trans-SNARE Complex Formation During Yeast Vacuole Fusion Using Epitope Tag-Free SNAREs.

SNARE complexes assembled between fusing membranes (in trans) are the core machinery driving lipid bilayer merger. Thus, an assay monitoring the formation of these trans-SNARE complexes is essential for SNARE-mediated membrane fusion studies. Homotypic yeast vacuole fusion is an important model system for such studies. Although several assays measuring trans-SNARE complex formation are available t...

Visualization of SNARE-Mediated Organelle Membrane Hemifusion by Electron Microscopy.

SNARE-mediated membrane fusion is required for membrane trafficking as well as organelle biogenesis and homeostasis. The membrane fusion reaction involves sequential formation of hemifusion intermediates, whereby lipid monolayers partially mix on route to complete bilayer merger. Studies of the Saccharomyces cerevisiae lysosomal vacuole have revealed many of the fundamental mechanisms that drive t...

Integrating psychosocial support into routine diabetes care: perspectives from participants at the Self-management Alliance meeting 2016.

To identify challenges and solutions to integrating psychosocial support into routine diabetes care from the perspective of stakeholders with an expertise in diabetes self-management education and support.

Designing and Developing a Mobile App for Clinical Decision Support: An Interprofessional Collaboration.

An Academic-Practice Partnership at the University of Washington School of Public Health: The Student Epidemic Action Leaders (SEAL) Team.

In 2015, the University of Washington School of Public Health, Department of Epidemiology established the Student Epidemic Action Leaders (SEAL) team to provide public health students with experience in field epidemiology in state and local public health communicable disease divisions. The University of Washington Department of Epidemiology developed the SEAL team in collaboration with the Washing...

Greater lateral root branching density in maize improves phosphorus acquisition from low phosphorus soil.

The development of crops with better growth under suboptimal phosphorus availability would improve food security in developing countries while reducing environmental pollution in developed countries. We tested the hypothesis that maize (Zea mays) phenotypes with greater lateral root branching density have greater phosphorus acquisition from low phosphorus soils. Recombinant inbred lines with eithe...

Interpersonal brain synchronization associated with working alliance during psychological counseling.

The mechanisms underlying behavioral synchrony during psychological counseling are not clear. Recent research has provided evidence that pervasive synchrony is associated with interpersonal brain synchronization (IBS) and possibly contributes to the positive working alliance-the degree to which the counseling dyads engage in collaborative and purposive work. Our study explored the IBS between the ...

Ragweeds and relatives: molecular phylogenetics of Ambrosiinae (Asteraceae).

Ambrosiinae are one of the most distinct subtribes in the Heliantheae alliance (Asteraceae), mainly due to specialization toward wind pollination. Taxa of the subtribe are principally native to the Americas, although some species have attained a cosmopolitan distribution Members of subtribe Engelmanniinae are considered close to Ambrosiinae, due to shared morphological traits. However, the placeme...

Special Viral Clearance Issue and St Gallen PDA Collaboration Paper.

HcPT1.2 participates in Pi acquisition in Hebeloma cylindrosporum external hyphae of ectomycorrhizas under high and low phosphate conditions.

Ectomycorrhizal fungi improve tree phosphorus nutrition through transporters specifically localized at soil-hyphae and symbiotic interfaces. In the model symbiosis between the fungus Hebeloma cylindrosporum and the maritime pine (Pinus pinaster), several transporters possibly involved in phosphate fluxes were identified, including three H:Pi transporters. Among these three, we recently unraveled t...

Evaluation of a Hospital: Community Partnership to Reduce 30-Day Readmissions.

To evaluate the ComPass program by (1) effectiveness in reducing 30-day hospital readmissions, (2) reach of program into target population, and (3) implementation of key program elements.

Cis-trans controls and regulatory novelty accompanying allopolyploidization.

Allopolyploidy is a prevalent process in plants, having important physiological, ecological, and evolutionary consequences. Transcriptomic responses to genomic merger and doubling have been demonstrated in many allopolyploid systems, encompassing a diversity of phenomena including homoeolog expression bias, genome dominance, expression-level dominance, and revamping of co-expression networks. Notw...

Bacterial Siderophores Promote Animal Host Iron Acquisition and Growth.

Siderophores are small molecules produced by bacteria that bind ferric iron in the surrounding environment with extraordinary affinity. A new study provides evidence that a simple animal host, Caenorhabditis elegans, co-opts siderophores to promote its own iron acquisition and growth.

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