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Middle Ear (Otitis media) and Tympanic Membrane Disorders Research

09:25 EST 24th January 2020 | BioPortfolio

Improving the quality of care for people who had a stroke in a low-/middle-income country: A qualitative analysis of health-care professionals' perspectives.

Efforts to improve the adoption of evidence-based interventions for optimal patient outcomes in low-/middle-income countries (LMICs) are persistently hampered by a plethora of barriers. Yet, little is known about strategies to address such barriers to improve quality stroke care. This study seeks to explore health professionals' views on strategies to improve quality stroke care for people who had...

Practical Guide to Evaluating Myocardial Disease by Cardiac MRI.

A spectrum of pathophysiologic mechanisms can lead to the development of myocardial disorders including ischemia, genetic abnormalities, and systemic disorders. Cardiac MRI identifies different myocardial disorders, provides prognostic information, and directs therapy. In comparison with other imaging modalities, cardiac MRI has the advantage of allowing both functional assessment and tissues char...

Organic liquid mixture separation using an aliphatic polyketone-based organic solvent reverse osmosis (OSRO) membrane.

Energy-efficient membrane technology has received tremendous attention for the separation of organic molecules, however, the separation of molecules of less than 100 Da has remained challenging. Herein, a membrane fabricated from interfacial polymerization on a polyketone support was performed as an organic solvent reverse osmosis (OSRO) membrane for the separation of organic liquid mixtures. The ...

Revealing Molecular-Level Interaction between a Polymeric Drug and Model Membrane via SFG and Microfluidics.

Body fluids flow all over the body and affect the biological processes at bio-interfaces. To simulate such a case, sum frequency generation (SFG) vibrational spectroscopy and a self-designed microfluidic chip were combined together to investigate the interaction between a pH-responsive polymeric drug, poly(α-propylacrylic acid) (PPAAc) and the model cell membranes in different liquid environments...

Making Novel Genetic Associations With Carotid Intima-Media Thickness Using the UK Biobank.

Dynamin 2 interacts with alpha-actinin 4 to drive tumor cell invasion.

The large GTPase Dynamin 2 (Dyn2) is known to increase the invasiveness of pancreatic cancer tumor cells, but the mechanisms by which Dyn2 regulates changes in the actin cytoskeleton to drive cell migration are still unclear. Here we report that a direct interaction between Dyn2 and the actin bundling protein alpha-actinin (α-actinin) 4 is critical for tumor cell migration and remodeling of the e...

Abl signaling directs growth of a pioneer axon in by shaping the intrinsic fluctuations of actin.

The fundamental problem in axon growth and guidance is to understand how cytoplasmic signaling modulates the cytoskeleton to produce directed growth cone motility. In the accompanying paper, we used live imaging of the TSM1 axon of the developing wing to show that the essential role of the core guidance signaling molecule, Abl tyrosine kinase, is to modulate the organization and spatial localizat...

Mechanical stress triggers nuclear remodeling and the formation of Transmembrane Actin Nuclear lines with associated Nuclear Pore Complexes.

Mechanical stimulation of fibroblasts induces changes in the actin cytoskeleton including stress fiber reinforcement and realignment. Here we characterize the nuclear response to mechanical stimulation (uniaxial cyclic stretch). Using fluorescence microscopy and quantitative image analysis we find that stretch-induced nuclear elongation and alignment perpendicular to the stretch vector are depende...

Porins as helpers in mitochondrial protein translocation.

Mitochondria import the vast majority of their proteins via dedicated protein machineries. The translocase of the outer membrane (TOM complex) forms the main entry site for precursor proteins that are produced on cytosolic ribosomes. Subsequently, different protein sorting machineries transfer the incoming preproteins to the mitochondrial outer and inner membrane, the intermembrane space and the m...

The Impact of Self-Efficacy and Subjective Cognitive Complaints on Health Care Use Among Middle-Aged Adults.

Self-efficacy (SE) has been shown to be a remarkable cognitive factor affecting health. Subjective perception of memory and other cognitive failures (i.e., subjective cognitive complaints [SCC]) have been associated with self-perception. The authors studied whether SE is a relevant subjective variable in predicting SCC in middle-aged adults living in the community (N = 438) and explored the role o...

Phosphatidylethanolamine accelerates aggregation of the amyloidogenic N-terminal fragment of apoA-I.

Membrane lipid composition is known to influence aggregation and fibril formation of many amyloidogenic proteins. Here, we found that phosphatidylethanolamine (PE) accelerates aggregation of the N-terminal 1-83 fragment of an amyloidogenic G26R variant of apoA-I on lipid membranes. Circular dichroism and isothermal titration calorimetry measurements demonstrated that PE does not affect the α-heli...

A Middle School Program to Prevent E-Cigarette Use: A Pilot Study of "CATCH My Breath".

From 2017 to 2018, electronic cigarette (e-cigarette) use increased 78% among high school students and 48% among middle school students in the United States. However, few e-cigarette prevention interventions have been evaluated. We determined the feasibility and initial effectiveness of "CATCH My Breath," an e-cigarette prevention program, among a sample of middle schools in central Texas.

A tRial Evaluating Mid Cut-Off Value Membrane Clearance of Albumin and Light Chains in HemoDialysis Patients: A Safety Device Study.

A new class of dialysis membrane, the mid cut-off (MCO) dialyzer, has been developed to improve the clearance of uremic toxins in hemodialysis (HD). The a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HemoDialysis patients (REMOVAL-HD) study aimed to determine if regular use of MCO dialyzer was safe and specifically did not result in a significant loss of alb...

The outcomes of endoscopic myringoplasty: packing with gelatin sponge versus packing with nothing.

Packing with gelatin sponge has long been widely used in myringoplasty. However, there is no research on packing with nothing. To analyse the differences between packing with gelatin sponge and packing with nothing. Patients with tympanic membrane perforation were randomly divided into a packing with gelatin sponge group and a packing with nothing group. Differences between the groups were compare...

Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation.

Intravenous iodinated contrast media are commonly used with CT to evaluate disease and to determine treatment response. The risk of acute kidney injury (AKI) developing in patients with reduced kidney function following exposure to intravenous iodinated contrast media has been overstated. This is due primarily to historic lack of control groups sufficient to separate contrast-induced AKI (CI-AKI; ...

Variations in psychiatric morbidity between traumatized Norwegian, refugees and other immigrant patients in Oslo.

There is a lack of clinical studies that focus on different psychiatric disorders after trauma and the relationship with migration status. To examine differences in psychiatric morbidity in traumatized patients referred to psychiatric treatment in Southern Oslo. Hundred and ten patients with trauma background attending an outpatient clinic in Southern Oslo were studied. Forty-four of the participa...

Efficacy of balloon Eustachian tuboplasty on the quality of life in children with Eustachian tube dysfunction.

Balloon Eustachian Tuboplasty (BET) is used as a second-line treatment in cases in which adenoidectomy, paracentesis, and VT have failed. However, studies have not investigated the efficacy of this procedure as a first-line treatment. To evaluate the quality of life in children with chronic Eustachian tube dysfunction (ETD) after BET using the Otitis Media-6 (OM-6) questionnaire. We retrospectivel...

Middle East Respiratory Syndrome Coronavirus Transmission.

Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes a spectrum of respiratory illness, from asymptomatic to mild to fatal. MERS-CoV is transmitted sporadically from dromedary camels to humans and occasionally through human-to-human contact. Current epidemiologic evidence supports a major role in transmission for direct contact with live camels or humans with symptomatic MERS, ...

Mesoporous Silica Thin Membrane with Tunable Pore Size for Ultra-high Permeation and Precise Molecular Separation.

We report on our use of a thin-layered vertical mesoporous silica thin film (MSTF) with tunable pore size overlaid on an an-odic aluminum oxide (AAO) membrane for advancing water purification. The features of ultrathin thickness (ca. 20 nm), a uniform vertical pore orientation, low tortuosity, high porosity, and a hydrophilic surface endow the MSTF membranes with ultrahigh water permeability compa...

: From Glue Sticks to Computer Bits: Digitizing ECGs at the Milwaukee VAMC.

A Surgical Simulator for Tympanostomy Tube Insertion Incorporating Capacitive Sensing Technology to Track Instrument Placement.

We describe a device engineered for realistic simulation of myringotomy and tympanostomy tube insertion that tracks instrument placement and objectively measures operator proficiency. A 3-dimensional computer model of the external ear and cartilaginous external auditory canal was created from a normal maxillofacial computed tomography scan, and models for the bony external auditory canal and tympa...

Survival of emerging pathogen Acinetobacter baumannii in water environment exposed to different oxygen conditions.

Bacterium Acinetobacter baumannii is a leading cause of hospital infections. Over the last decade, its occurrence in natural environments outside hospital settings has been reported. The aim was to examine the survival of A. baumannii in water media exposed to different ranges of oxygen supply in order to predict its behaviour in the environment. The abundance of five A. baumannii isolates was mon...

Antibacterial activity and mechanism of linalool against Pseudomonas aeruginosa.

The purpose of this study was to evaluate the antibacterial activity and mechanism of linalool against Pseudomonas aeruginosa. The determination of antibacterial activity was based on the minimum inhibitory concentration (MIC) and the minimum bactericide concentration (MBC). Further, the antibacterial mechanism was explored by a growth curve assay, scanning electron microscopy (SEM), cell membrane...

Study of the intestinal uptake and permeability of gold nanoparticles using both in vitro and in vivo approaches.

Gold nanoparticles (AuNPs) are highly attractive to biomedical applications. Here, we investigated the effects of (i) ca. 15 nm spherical AuNPs capped with citrate or 11-mercaptoundecanoic acid (MUA), and (ii) ca. 60 nm spherical citrate-capped AuNPs, and ca. 60 nm MUA-capped star-shaped AuNPs on the cytotoxicity, cellular uptake and permeability, using media supplemented or not with 1% fetal bovi...

Evaluation of Hearing Thresholds by Using a Mobile Application in Children with Otitis Media with Effusion.

Otitis media with effusion (OME) is the most common cause of hearing loss in children. Early diagnosis is important as hearing loss affects speech and language development in children. The aim of this study was to compare conventional audiometry with the Android mobile operating system application Hearing TestTM in the evaluation of hearing thresholds in children with OME and to determine the accu...

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