Mild Cognitive impairment Research

08:40 EDT 18th October 2018 | BioPortfolio

Communication Predictors of Patient and Companion Satisfaction with Alzheimer's Genetic Risk Disclosure.

The objective of this study was to identify how features of Alzheimer's disease (AD) genetic risk disclosure communication relate to patient and visit companion satisfaction. We conducted secondary analyses of 79 session recordings from the fourth REVEAL Study, a randomized-controlled trial of AD genetic risk disclosure among patients with mild cognitive impairment. Patient and companion satisfact...

Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018.

Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderl...

Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery-2018.

Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderl...

Cognitive impairment correlates with serum carbonyl compound profiles in subclinical carotid atherosclerosis.

Current evidence indicates that carotid atherosclerosis is an independent risk factor for cognitive impairment. Serum metabolomic analysis holds significant promise for uncovering the relationship between carotid atherosclerosis and cognitive impairment. In this study, we aimed to evaluate the profiling of serum carbonyl compounds in subclinical carotid atherosclerosis (SCA) patients and to explor...

A Feasibility Study of a Multifaceted Walking Intervention to Maintain the Functional Mobility, Activities of Daily Living, and Quality of Life of Nursing Home Residents With Dementia.

The aim of the study was to evaluate the feasibility, acceptability, and efficacy of a multifaceted walking intervention (MWI) aimed to maintain the functional mobility, activities of daily living function, and quality of life of long-term care home residents with dementia.

Association of cognitive impairment with sleeping difficulties, anxiety and depression among Pakistani physicians.

Previous literature has highlighted a high burden of a variety of psychopathologies such as anxiety, depression, and poor sleep quality among Pakistani physicians. These psychopathologies are associated with a poor quality of life and cognitive difficulties, affecting empathy levels, doctor patient relationship, and work performance. It is a cross sectional study in which 300 Pakistani physicians ...

Inhibitory attentional control in anxiety: Manipulating cognitive load in an antisaccade task.

Theorists have proposed that heightened anxiety vulnerability is characterised by reduced attentional control performance and have made the prediction in turn that elevating cognitive load will adversely impact attentional control performance for high anxious individuals to a greater degree than low anxious individuals. Critically however, existing attempts to test this prediction have been limite...

Correction: Use of sedative-hypnotics and the risk of Alzheimer's dementia: A retrospective cohort study.

[This corrects the article DOI: 10.1371/journal.pone.0204413.].

Association of Androgen Deprivation Therapy With Dementia in Men With Prostate Cancer Who Receive Definitive Radiation Therapy.

Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration.

There is an increased risk of cognitive impairment or dementia in women who undergo bilateral salpingo-oophorectomy (BSO) before menopause. However, data are lacking on the association of BSO before menopause with imaging biomarkers that indicate medial temporal lobe neurodegeneration and Alzheimer disease pathophysiology.

Air Pollution Linked With Cognitive Harm in China.

Exercise-Induced Brain-Derived Neurotrophic Factor Expression: Therapeutic Implications for Alzheimer's Dementia.

Emerging evidence indicates that moderate intensity aerobic exercise is positively correlated with cognitive function and memory. However, the exact mechanisms underlying such improvements remain unclear. Recent research in animal models allows proposition of a pathway in which brain-derived neurotrophic factor (BDNF) is a key mediator. This perspective draws upon evidence from animal and human st...

Social anxiety and self-compassion in adolescents.

Social anxiety disorder is a prevalent mental illness with a young onset age. Preliminary evidence suggested that low self-compassion may contribute to adult social anxiety, but research with youth has lagged far behind. This study investigated the relationship between selfcompassion and social anxiety in adolescents. It also examined the mediating role of three cognitive mechanisms: fear of negat...

Design and development of novel p-aminobenzoic acid derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease.

Based on the quantitative structure-activity relationship (QSAR), some novel p-aminobenzoic acid derivatives as promising cholinesterase enzyme inhibitors were designed, synthesized, characterized and evaluated to enhance learning and memory. The in vitro enzyme kinetic study of the synthesized compounds revealed the type of inhibition on the respective acetylcholinesterase (AChE) and butyrylcholi...

The Relationship between Mismatch Negativity and the COMTVal108/158Met Genotype in Schizophrenia.

Mismatch negativity (MMN) is a component of auditory event-related potentials that reflects automatic change detection in the brain, showing qualities of endophenotypes in schizophrenia. MMN deficiency is one of the robust findings in patients, and it reflects both cognitive and functional decline. Catechol-o-methyltransferase (COMT) is a key enzyme involved in regulating dopamine transmission wit...

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction.

Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity.

Discriminative Accuracy of 18Fflortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders.

The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear.

Assessment of cognitive-driven activity of daily living impairment in non-demented Parkinson's patients.

The core criterion for Parkinson's disease dementia (PDD) is the impairment in activities of daily living (ADL) function primarily caused by cognitive, not motor symptoms. There is evidence to assume that mild ADL impairments in mild cognitive impairment (PD-MCI) characterize those patients at high risk for dementia. Data of 216 Parkinson's disease (PD) patients assessed with comprehensive motor a...

Introduction to the special issue on the cognitive functions of the retrosplenial cortex.

This special issue on the cognitive functions of the retrosplenial cortex highlights progress that has been made in recent years in understanding the anatomy and function of the retrosplenial cortex in both animals and humans. The articles in this issue of Behavioral Neuroscience use a number of different approaches that together provide an up-to-date account of recent progress in understanding ho...

The Russian version of the Oxford Cognitive Screen: Validation study on stroke survivors.

The Oxford Cognitive Screen (OCS) is a screening tool for the assessment of poststroke deficits in attention, memory, praxis, language, and number processing. The goal of the present study was to develop a Russian version of the OCS (Rus-OCS) via translation of the original battery, its cultural and linguistic adaptations, and reporting preliminary findings on its psychometric properties.

Beneficial effects of rutin in diabetes-induced deficits in acquisition learning, retention memory and pain perception in rats.

Cognitive impairment and hyperalgesia are among the common manifestations of diabetes. Hyperglycemia may contribute to their developments but the exact pathophysiology underlying these complications is not fully understood. Flavonoids from plants original have beneficial effects on diabetes by improving glycemic control. Rutin (RUT) is a bioflavonoid found in many plants and foods with many biolog...

Consultations on driving in people with cognitive impairment in primary care: A scoping review of the evidence.

To review the empirical evidence on approaches used by Primary Care Physicians (PCPs) in fitness to drive (FtD) consultations with people living with cognitive impairment.

Association of visual hallucinations with very mild degenerative dementia due to dementia with Lewy bodies.

Complex, well-formed, and detailed visual hallucinations (VHs) are among the core clinical features of dementia with Lewy bodies (DLB). We investigated the diagnostic value of VHs in different types of very mild degenerative dementia.

Holistic cognitive and neural processes: a fNIRS-hyperscanning study on interpersonal sensorimotor synchronization.

Interpersonal sensorimotor synchronization (interpersonal SMS) is the foundation of complex human social interaction. Previous studies primarily focused on the individual cognitive processes of interpersonal SMS. However, all individuals compose an entire interaction system with emerged holistic properties during interpersonal SMS. Therefore, we proposed the `holistic cognitive and neural processe...

Longitudinal Cognitive Performance in Individuals at Ultrahigh Risk for Psychosis: A 10-year Follow-up.

It remains unclear whether the onset of psychosis is associated with deterioration in cognitive performance. The aim of this study was to examine the course of cognitive performance in an ultrahigh risk (UHR) cohort, and whether change in cognition is associated with transition to psychosis and change in functioning. Consecutive admissions to Personal Assessment and Crisis Evaluation (PACE) Clinic...

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