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Nephrology - kidney function Research

16:20 EST 22nd February 2019 | BioPortfolio

Angiotensin II and salt-induced decompensation in Balb/CJ mice is aggravated by fluid retention related to low oxidative stress.

Balb/CJ mice are more sensitive to treatment with Angiotensin II (AngII) and high salt (Salt) diet compared to C57BL/6J. Together with higher mortality, they develop edema, signs of heart failure and acute kidney injury. The aim of the present study was to identify differences in renal gene regulation that may affect kidney function and fluid balance, which could contribute to decompensation in Ba...

"A complex interface: Exploring sickle cell disease from a parent's perspective, after moving from Sub-Saharan Africa to North America".

Sickle cell disease (SCD) is an inherited, multi-system, chronic disease with the highest prevalence affecting people of Sub-Saharan African descent. While major advances in SCD care have occurred over the last few decades in many African countries these advances are not readily available. Prior literature from Ghana and Kenya describe stigma, despair, and economic burden as well as hope when a ch...

Ginseng Extract Modified by Pectin Lyase Inhibits Retinal Vascular Injury and Blood-Retinal Barrier Breakage in a Rat Model of Diabetes.

GS-E3D is an enzymatically modified ginseng extract by pectin lyase. In this study, we evaluated the preventive effects of GS-E3D on blood-retinal barrier (BRB) leakage in a rat model of diabetes. To produce diabetes, rats were injected with streptozotocin. GS-E3D was orally gavaged at 25, 50, and 100 mg/kg body weight for 6 weeks. We then compared the effect of GS-E3D with that of an unmodified...

An experimental study of exenatide effects on renal injury in diabetic rats1.

To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats.

LBP reduces theinflammatory injuryof kidney in septic rat and regulates the Keap1-Nrf2∕ARE signaling pathway1.

To investigate the influence of lycium barbarum polysaccharides (LBP), a functional derivative from lycium barbarum, on septic kidney injury.

The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells1.

To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.

Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-11.

To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN).

HEPATITIS C IN THE BRAZILIAN PUBLIC HEALTH CARE SYSTEM: BURDEN OF DISEASE.

Infection by hepatitis C virus is one of the leading causes of chronic hepatitis C and cause severe burden for patients, families and the health care system.

PROFILE OF PATIENTS WITH CHRONIC HEPATITIS C IN A PUBLIC HEALTH PROGRAM IN SOUTHERN BRAZIL.

Chronic hepatitis C (CHC) can progress to cirrhosis and its complications as hepatocellular carcinoma, leading to morbidity and mortality. To know the profile of patients with CHC virus is fundamental to optimize management.

Lower limb wounds in diabetic and non-diabetic patients: survival analysis.

To evaluate the survival of wounds in lower limbs of diabetic and non-diabetic patients.

Knowledge and practices for the prevention of the diabetic foot.

Describe the knowledge and practices performed by people for diabetic foot prevention.

Increased serum gastrin in patients with different clinical forms of Chagas disease coinfected with Helicobacter pylori.

Trypanosoma cruzi and Helicobacter pylori (HP) are pathogens that cause chronic diseases and have been associated with hypergastrinemia. The aim of this study was to evaluate the fasting gastrin levels in patients with different clinical forms of Chagas disease (CD), coinfected or not by HP. The enrolled individuals were outpatients attending at the university hospital. HP infection was assessed b...

Exercise and Garlic Modulate microRNAs Involved in Diabetic Cardiopathy.

Cardiac Effects of Trimetazidine in Diabetic Rats.

Systematic review of randomized controlled trials on antibiotic treatment for osteomyelitis in diabetes.

To evaluate the efficacy of antibiotic therapy in osteomyelitis treatment among people with diabetes.

Dietary intakes of women with Type 1 diabetes before and during pregnancy: a pre-specified secondary subgroup analysis among CONCEPTT participants.

To describe the dietary intakes of women with Type 1 diabetes before and during pregnancy.

Comment on the consensus report on the management of hyperglycaemia in Type 2 diabetes by the American Diabetes Association and the European Association for the Study of Diabetes.

We read with interest the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) joint consensus report on the management of hyperglycaemia in Type 2 diabetes. Following publication of the report, discussions of the content among networks of behavioural and educational researchers prompted us to write this letter. This consensus report is to be commended ...

Ocular dialysis disequilibrium-Management of intraocular pressure during hemodialysis of open angle glaucoma: A case report and review of the literature.

It has been shown that patients with end-stage renal disease (ESRD) have an increased risk for changes in intraocular pressure during hemodialysis, or ocular dialysis disequilibrium which can cause pain or discomfort during treatment and lead to decreased vision over time. This is a case of an elderly male with ESRD who was having headaches, nausea, and eye pain during hemodialysis due to increase...

The skin as « third kidney ».

The skin is the largest human organ playing an important role in protection, thermoregulation and sensation. Recent studies suggest that a new function has to be added: the storage of sodium. There is increasing evidence that sodium can accumulate in the skin, which suggests that the skin contributes to the regulation of sodium balance in humans, and possibly to the control of extracellular volume...

Hepatorenal syndrome : something new?

Hepatorenal syndrome is a serious and frequent complication in patients suffering from liver cirrhosis. Its most severe type is characterized by the rapid occurrence of a functional acute kidney injury. However it is mainly an exclusion diagnosis. Although the pathophysiology is not yet fully understood, the principal hypothesis is a splanchnic vasodilatation leading to a systemic and renal vasoco...

Cytological characteristic of the buccal cells in chronic generalized periodontite.

The research is devoted to the study of the occurrence of abnomal cells in buccal epithelium in patients with chronic generalize periodontitis. Buccal cytograms of 102 patients were examined. It was established that cells with karyopycnosis, karyorexis and karyolysis are a sensitive index of the initial stage (mild severity) in periodontitis. The number of buccal cells with these features was incr...

Renal Cortical Perfusion, Measured by Superb Microvascular Imaging, During Infusion of Norepinephrine in Experimental Cardiopulmonary Bypass.

High glucose-induced ubiquitination of G6PD leads to the injury of podocytes.

Oxidative stress contributes substantially to podocyte injury, which plays an important role in the development of diabetic kidney disease. The mechanism of hyperglycemia-induced oxidative stress in podocytes is not fully understood. Glucose-6-phosphate dehydrogenase (G6PD) is critical in maintaining NADPH, which is an important cofactor for the antioxidant system. Here, we hypothesized that high ...

Non-communicable diseases and tuberculosis: Anticipating the impending global storm.

The epidemiological transitions that have occurred in low and middle income countries (LMIC) during the past decades have led to an increased prevalence on non-communicable diseases (NCDs) in these countries, where the burden of infectious diseases (IDs), especially tuberculosis (TB), remains high. Although the true dimensions of this comorbidity have not yet been fully understood, there is a grow...

Nine-year distribution pattern of hepatitis C virus (HCV) genotypes in Southern Italy.

It has been greatly described that different hepatitis C virus (HCV) genotypes are strictly correlated to various evolution, prognosis and response to therapy during the chronic liver disease. Aim of this study was to outline the changes in the epidemiology of Hepatitis C genotypes in Southern Italy regions from 2006 to 2014.

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