Latest Biotechnology, Pharmaceutical and Healthcare News from The Lancet

05:08 EDT 24th June 2018 | BioPortfolio

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Showing News Articles 1–25 of 776 from The Lancet

Saturday 23rd June 2018

[Articles] MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

MEDI0382 has the potential to deliver clinically meaningful reductions in blood glucose and bodyweight in obese or overweight individuals with type 2 diabetes.

[Comment] Agonism of receptors in the gut–pancreas axis in type 2 diabetes: are two better than one?

Pharmacotherapy for type 2 diabetes has become complex with the advent of a large number of treatment options. Major goals of therapy include achieving glycaemic targets (glycated haemoglobin [HbA1c] ≤7%) to minimise the development and progression of microvascular and, to a lesser extent, macrovascular complications, while avoiding hypoglycaemia.1 Obesity is a key risk factor of type 2 diabetes...

Thursday 21st June 2018

[Seminar] Sepsis and septic shock

Sepsis is a common condition that is associated with unacceptably high mortality and, for many of those who survive, long-term morbidity. Increased awareness of the condition resulting from ongoing campaigns and the evidence arising from research in the past 10 years have increased understanding of this problem among clinicians and lay people, and have led to improved outcomes. The World Health As...

[Articles] Personalised perioperative care by e-health after intermediate-grade abdominal surgery: a multicentre, single-blind, randomised, placebo-controlled trial

A personalised e-health intervention after abdominal surgery speeds up the return to normal activities compared with usual care. Implementation of this e-health programme is recommended in patients undergoing intermediate-grade abdominal, gynaecological, or general surgical procedures.

[Articles] Police killings and their spillover effects on the mental health of black Americans: a population-based, quasi-experimental study

Police killings of unarmed black Americans have adverse effects on mental health among black American adults in the general population. Programmes should be implemented to decrease the frequency of police killings and to mitigate adverse mental health effects within communities when such killings do occur.

[Comment] Personalised recovery after general and gynaecologic surgery

Over the past decade, attention on post-surgical recovery has increased. Enhanced recovery pathways have been developed that focus on improving clinical outcomes such as complications and length of stay after major abdominal surgery. Despite their effectiveness, these pathways do not extend beyond discharge and sometimes fail to incorporate patient-reported outcome measures.1 Recovery periods afte...

[Comment] Police violence and the built harm of structural racism

Police killing black Americans is one of the oldest forms of structural racism in the USA. The act traces its roots to slavery.1 Yet it remains a tool for social control that violates black bodily autonomy, engenders racial inequality in access to public services, and re-inscribes the predominant racial order any time police indiscriminately and extrajudicially take a black life.2

Wednesday 20th June 2018

[Review] Unanswered questions about the 1918 influenza pandemic: origin, pathology, and the virus itself

The influenza epidemic of 1918 represented the greatest failure of medical science in the 20th century. Fortunately, research throughout subsequent years has been making amends. Some studies have applied RT-PCR to the tissue samples from that time, whereas others have reconstructed the pathogen in its virulent state. But the resurrection of the 1918 influenza virus leaves questions unanswered: alt...

Tuesday 19th June 2018

[Personal View] Unexpected outbreaks of arbovirus infections: lessons learned from the Pacific and tropical America

Pandemic arboviruses have emerged as a major global health problem in the past four decades. Predicting where and when the next arbovirus epidemic will occur is a challenge, but history suggests that arboviral black swan events (epidemics that are difficult to predict and that have an extreme effect) will continue to occur as urban growth and globalisation expand. We briefly review unexpected arbo...

[Articles] Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial

Rasagiline was safe in patients with amyotrophic lateral sclerosis. There was no difference between groups in the primary outcome of survival, although post-hoc analysis suggested that rasagiline might modify disease progression in patients with an initial slope of Amyotrophic Lateral Sclerosis Functional Rating Scale Revised greater than 0·5 points per month at baseline. This should be confirmed...

[Articles] Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial

Cognitive behavioural therapy increased the capacity for activity and social participation in patients with myotonic dystrophy type 1 at 10 months. With no curative treatment and few symptomatic treatments, cognitive behavioural therapy could be considered for use in severely fatigued patients with myotonic dystrophy type 1.

[Comment] When a negative trial in ALS has a positive effect on research

In the past 5 years, amazing progress has been made in the development of therapies for amyotrophic lateral sclerosis (ALS). New genetic causes have been identified, including the C9orf72 hexanucleotide repeat, TDP43, TBK1, and others,1 which have provided key insights into underlying mechanisms and catalysed the development of new models for drug discovery. Additionally, in 2017, the US Food and ...

[Comment] Myotonic dystrophy type 1: reasons to be OPTIMISTIC

Myotonic dystrophy type 1, the most common adult-onset form of muscular dystrophy, is a multisystem disease with progressively worsening symptoms. Fatigue constitutes the most common non-muscular symptom in patients with this disease,1 and can exact a heavy toll on their quality of life. In The Lancet Neurology, Kees Okkersen and other investigators from the OPTIMISTIC consortium2 report the effec...

Monday 18th June 2018

[Articles] Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy adults: a randomised, first-in-human phase 1 study

REGN3470-3471-3479 was well tolerated, displayed linear pharmacokinetics, and did not lead to detectable immunogenicity. These data support further clinical development of REGN3470-3471-3479 as a single-dose therapeutic drug for acute Ebola virus infection.

[Comment] Following the roadmap toward an effective Ebola virus treatment

Ebola virus is a highly pathogenic virus and the causative agent of Ebola virus disease. Numerous outbreaks have happened since its discovery in 1976, including the largest outbreak to date in west Africa in 2014–16, which resulted in 28,616 infections and 11 310 deaths.1 The international response effort in west Africa was heavily criticised for being much too slow2,3 and for the lack of vacc...

[World Report] 50 years of Medicare

In July, 1965, Medicare, America's landmark national health insurance programme, became law. Today, it covers 55 million people. Susan Jaffe, The Lancet's Washington correspondent, reports.

[Comment] Cultural specificity in alcohol use disorders

In their Seminar on alcohol use disorders, Jason Connor and colleagues1 summarise the risk of alcohol consumption to health for the drinker and for whole populations. The authors offer useful advice, insofar as the evidence base allows, on how clinicians should respond to and try to change a patient's hazardous and harmful drinking pattern. The evidence base is from a narrow range of the world's c...

[Clinical Picture] Striking but benign: acute haemorrhagic oedema of infancy

A previously healthy 6-month-old boy presented in September, 2014, with indurated and tender oedema of the left hand, associated with a rapidly spreading purpuric rash on the dorsum. He also had swelling of one side of his face, but examination was otherwise normal. Beginning 4 days previously he had had a 3-day upper respiratory tract infection, with no associated fever; his parents denied trauma...

[Clinical Picture] Pyogenic granuloma-like Kaposi's sarcoma

A 30-year-old man presented to the primary care clinic in June, 2015, with a 3 month history of a painful, foul-smelling mass between the second and third toes of his right foot that had been slowly increasing in size. The mass had begun as a small nodule and had originally been treated with antibiotics for presumed infection without success.

[Clinical Picture] Melanoma in a Chinese dragon tattoo

A 42-year-old white man presented to our clinic in October, 2015, with itching in the nasolabial fold and around the eyebrows, with accompaying erythema and desquamation consistent with seborrhoeic dermatitis. We noted multiple naevi on whole body dermatological examination, as well as a multicoloured tattoo of a Chinese dragon covering almost his entire back, arms, and chest. On closer inspection...

[Clinical Picture] Intravascular tumour embolism from chondrosarcoma

A 48-year-old woman with a history of sternal chondrosarcoma that had been completely resected 3 years previously presented with a 7-month history of cough and progressive dyspnoea. On admission she had blood oxygen saturation of 88%.

[Comment] Women, power, and the cancer divide

Almost 100 years ago, Gabriela Mistral, Chilean poet and Nobel Prize winner, said that “every law, every freedom or culture movement, has left us for a long time in the shadows; that we always have arrived to the feast not as the reluctant guest who is arriving late, but as a comrade who is invited late and then hides in the banquet”.1 Mistral reminds us that, despite many hard won achievement...

[Essay] My dying student

As a doctor for almost 40 years now, and especially as a geriatrician, I have cared for my share of terminal patients. However, to date I have never had to face a dying medical student. As Sakal's Dean, this was especially onerous. And I know that one is not supposed to confess this, as in the eyes of the faculty all students are equal, but Sakal was one of my favourites. That being said, I am sur...

[Department of Error] Department of Error

Psoriatic arthritis: classification and holistic management. Lancet 2018; 391: 2185—In this Editorial, the abbreviation for the Classification of Psoriasis Arthritis criteria should have been “CASPAR”. This correction has been made to the online version as of June 11, 2018.

[Corrections] Corrections

Witkowski B, Duru V, Khim N, et al. A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study. Lancet Infect Dis 2017; 17: 174–83—In this Article, the copyright line should have been “© 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.” This correction has been made to the on...

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