Latest Biotechnology, Pharmaceutical and Healthcare News from The Lancet

18:29 EDT 22nd September 2018 | BioPortfolio

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Showing News Articles 1–25 of 684 from The Lancet

Saturday 22nd September 2018

[Articles] Thin composite wire strut, durable polymer-coated (Resolute Onyx) versus ultrathin cobalt–chromium strut, bioresorbable polymer-coated (Orsiro) drug-eluting stents in allcomers with coronary artery disease (BIONYX): an international, single-b

The Resolute Onyx stent was non-inferior to Orsiro for a combined safety and efficacy endpoint at 1-year follow-up in allcomers. The low event rate in both groups suggests that both stents are safe, and the very low rate of stent thrombosis in the Resolute Onyx group warrants further clinical investigation.

[Comment] Are all drug-eluting stents created equal?

Non-inferiority trials with combined clinical endpoints in allcomer populations were suggested as a compromise between premarket assessments and speed of innovation.1 However, it is important to remain aware of the limitations of the information provided by these trials. In The Lancet, Clemens von Birgelen and colleagues2 report their comparison of two highly regarded drug-eluting stents in clinic...

Friday 21st September 2018

[In Context] The science of today is all about tomorrow

Perhaps some remember science lessons at school as intimidating, or even boring, associated with something out of reach: esoteric or mysterious. Making science relevant, meaningful, or accessible to the non-scientist is important if you want to engage “the ordinary visitor”, a term used by the previous director of what is now known as the Science Museum (London, UK), Colonel Sir Henry Lyons. S...

[Comment] 10 years after the Commission on Social Determinants of Health: social injustice is still killing on a grand scale

In 2008, WHO launched the final report of the Commission on Social Determinants of Health (CSDH) that concluded “social injustice is killing people on a grand scale”.1 A decade later, how should we judge the CSDH's impact? A Google search for the CSDH yields 156 000 results and the accompanying Lancet paper has had 932 citations.2 The CSDH led to two World Health Assembly resolutions and mor...

[Articles] Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study

The addition of ustekinumab to standard-of-care treatment resulted in better efficacy in clinical and laboratory parameters than placebo in the treatment of active systemic lupus erythematosus and had a safety profile consistent with ustekinumab therapy in other diseases. The results of this study support further development of ustekinumab as a novel treatment in systemic lupus erythematosus.

[Comment] Ustekinumab: a promising new drug for SLE?

In The Lancet, Ronald van Vollenhoven and colleagues1 report a positive multicentre double-blind phase 2 randomised, placebo-controlled trial with ustekinumab, an anti-interleukin-12/23 (IL-12/23) monoclonal antibody, in 102 patients aged 18–75 years with active systemic lupus erythematosus (93 women and nine men). The design of the study is common for trials of biotherapies in patients with sys...

Thursday 20th September 2018

[Correspondence] Partnerships with the alcohol industry: opportunities and risks

The continuing health harms of alcohol1 require action not inaction.2 A range of effective policy interventions are available, and Public Health England (PHE) has been prominent in bringing all of these to the attention of policy makers.3 In The Lancet, Mark Petticrew and colleagues4 discuss PHE's partnership with the charity Drinkaware and suggest that such collaborations could be at the expense ...

[Review] Comorbidities, treatment, and pathophysiology in restless legs syndrome

Restless legs syndrome, also known as Willis-Ekbom disease, is a common neurological condition whose manifestation is affected by complex environmental and genetic interactions. Restless legs syndrome can occur on its own, mostly at a young age, or with comorbidities such as cardiovascular disease, diabetes, and arterial hypertension, making it a difficult condition to properly diagnose. However, ...

[Review] Nutrition and prevention of cognitive impairment

Nutrition is an important lifestyle factor that can modify the risk of future cognitive impairment and dementia. Some, but not conclusive, evidence (mostly from observational studies and infrequently from clinical trials) exists of a protective association between certain nutrients (eg, folate, flavonoids, vitamin D, and certain lipids) or food groups (eg, seafood, vegetables, and fruits, and pote...

Wednesday 19th September 2018

[Articles] Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Our findings show substantial progress in the reduction of lower respiratory infection burden, but this progress has not been equal across locations, has been driven by decreases in several primary risk factors, and might require more effort among elderly adults. By highlighting regions and populations with the highest burden, and the risk factors that could have the greatest effect, funders, poli...

[Articles] Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

Substantial progress has been made globally in reducing the burden of diarrhoeal diseases, driven by decreases in several primary risk factors. However, this reduction has not been equal across locations, and burden among adults older than 70 years requires attention.

[Comment] The global burden of lower respiratory infections: making progress, but we need to do better

Pneumonia is a major global killer of both children and adults. Much of its burden is preventable, which places an onus on the global health community to better direct efforts to reduce this burden. In response, WHO's Integrated Global Action Plan for the Prevention and Control of Pneumonia and Diarrhoea has set targets and a framework for tackling this challenge, an important component being to m...

[Comment] Old and new challenges related to global burden of diarrhoea

The Global Burden of Disease (GBD) project has five major objectives: improve control of disease burdens, generate opportunities for informed debate, identify disease control priorities, create knowledge about diseases, and enable rational allocation of resources for disease control.1 Of the diseases that any national Ministry of Health should combat, diarrhoeal diseases are among the most challen...

[Articles] Biological and clinical manifestations of juvenile Huntington's disease: a retrospective analysis

Patients with HE juvenile Huntington's disease differ clinically from patients with LE juvenile Huntington's disease or adult-onset Huntington's disease, suggesting reclassification of this particularly aggressive form of Huntington's disease might be required.

[Comment] Juvenile Huntington's disease: left behind?

Most movement disorders specialists will care for only a handful of children with juvenile Huntington's disease (onset at age 20 years or younger) during a lifetime of clinical practice. Therefore, the retrospective study of 36 children and adolescents with juvenile Huntington's disease reported by Caterina Fusilli and colleagues1 in The Lancet Neurology is extraordinary because this sample size, ...

Tuesday 18th September 2018

[Articles] Amoxicillin–clavulanate versus azithromycin for respiratory exacerbations in children with bronchiectasis (BEST-2): a multicentre, double-blind, non-inferiority, randomised controlled trial

By 21 days of treatment, azithromycin is non-inferior to amoxicillin–clavulanate for resolving exacerbations in children with non-severe bronchiectasis. In some patients, such as those with penicillin hypersensitivity or those likely to have poor adherence, azithromycin provides another option for treating exacerbations, but must be balanced with risk of treatment failure (within a 20% margin), ...

[Comment] Treatment of bronchiectasis exacerbations in children: which antibiotic?

Bronchiectasis in children that is unrelated to cystic fibrosis is a relatively neglected disease. However, it is an important cause of respiratory morbidity in low-income and middle-income countries (occurring as a sequela of lower respiratory tract infection) as well as in specific populations in high-income countries such as Aboriginal or Maori and Pacific Islander populations.1 Most adult bron...

Monday 17th September 2018

[Correspondence] Did Caravaggio die of Staphylococcus aureus sepsis?

Caravaggio, also known as Michelangelo Merisi (1571–1610), was a revolutionary painter who influenced many artists during his lifetime and after his death (figure). The painter had a turbulent life during which he was involved in many fights and battles. Caravaggio left Rome after he was sentenced to death, and one final fight forced him to leave Chiaia in Naples around July 9, 1610. Navigating ...

Wednesday 12th September 2018

[Articles] Circadian and circaseptan rhythms in human epilepsy: a retrospective cohort study

Our results suggest that seizure cycles are robust, patient specific, and more widespread than previously understood. They align with the accepted consensus that most epilepsies have some diurnal influence. Variations in seizure rate have important clinical implications. Detection and tracking of seizure cycles on a patient-specific basis should be standard in epilepsy management practices.

[Comment] From moon to earth—ultradian cycles in brain excitability

In chronic disease, human nature drives the identification of factors that influence the often-fluctuating course. The formerly used term “lunatic” for patients suffering from psychiatric diseases and epilepsy was a reflection of suspected mensual influences associated with the phases of the moon. Such speculative explanations1 of individual experiences over time was replaced by descriptive st...

[Correspondence] Support for UNRWA's survival

The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides life-saving humanitarian aid for 5·4 million Palestine refugees now entering their eighth decade of statelessness and conflict. About a third of Palestine refugees still live in 58 recognised camps. UNRWA operates 702 schools and 144 health centres, some of which are affected by the ongoing humanit...

[Comment] Informing NCD control efforts in India on the eve of Ayushman Bharat

The Government of India recently launched the ambitious National Health Protection Mission, also referred to as Ayushman Bharat (which means “bless India with long healthy life”), Pradhan Mantri Jan Arogya Yojana, or Modicare. This scheme has two main pillars: strengthening of universal comprehensive primary health care and a health insurance scheme to cover 500 million people in need to reduc...

[Comment] Offline: The new politics of health in India

“There is a full-blown crisis in India.” So said Rahul Gandhi, President of the Indian National Congress Party, during a visit to the London School of Economics last month. He was talking about a “jobs crisis”. But there is also a health crisis, as five papers published across three Lancet specialty journals—Lancet Oncology, Global Health, and Public Health—set out this week. Now is th...

Tuesday 11th September 2018

[Articles] Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study

Dairy consumption was associated with lower risk of mortality and major cardiovascular disease events in a diverse multinational cohort.

[Comment] No need to change dairy food dietary guidelines yet

The role of dairy products in the development of cardiovascular disease and mortality has been the focus of several epidemiological studies and meta-analyses.1–6 Although a trend towards a protective effect is generally observed, the association between dairy consumption and cardiovascular disease is still inconclusive. Differences in outcomes might be due to a number of factors, including under...

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