Latest Biotechnology, Pharmaceutical and Healthcare News from 2 Minute Medicine

19:24 EDT 19th June 2019 | BioPortfolio

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Showing News Articles 1–25 of 629 from 2 Minute Medicine

Wednesday 19th June 2019

#VisualAbstract: Effect of Neladenoson Bialanate on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction

1. In this randomized controlled trial, heart failure with preserved ejection fraction (HFpEF) patients did not have improved exercise capacity with neladenoson versus placebo. 2. There were no changes in activity intensity, NT-proBNP level, high-sensitivity troponin T level, or quality of life with neladenoson. Evidence Rating Level: 1 (Excellent) Study Rundown: Heart failure with preserved ejec...

Bacteremia in pediatric pneumonia associated with disease severity

1. In this retrospective analysis of prospectively collected data, researchers found that pediatric patients with pneumonia and bacteremia were more likely to have serious disease including longer hospital stays, increased likelihood of being in the intensive care unit (ICU), and increased need for mechanical ventilation. 2. Clinical outcomes varied based on the pathogen identified in […]&nb...

Tuesday 18th June 2019

Being denied a wanted abortion may have detrimental health effects in the long term

1. The authors of this prospective cohort study found that women who were denied a wanted abortion were found to have higher rates of chronic headaches and migraines. 2. There were no significant differences observed in reports of overall health or chronic pain among women who received a first-trimester absorption compared to a second-trimester abortion. […] Source: 2 Minute Medicine

Monday 17th June 2019

Quick Take: The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults

Oral live-attenuated polio vaccines (OPV) and injected inactivated polio vaccines IPV) have helped eradicate wild polioviruses. However, there is still a need to develop new vaccines due to risk of outbreaks of vaccine-derived polioviruses. In the process of developing new vaccines, it is important to study the safety of the viruses and possible release into […] Source:

Sunday 16th June 2019

Quick Take: Association of Cortical Stimulation–Induced Seizure With Surgical Outcome in Patients With Focal Drug-Resistant Epilepsy

Cortical stimulation during intracranial electroencephalography (EEG) is used in defining the epileptogenic zone in patients with epilepsy, with the aim of removing the seizure onset zone (SOZ). However, the effect of cortical stimulation on surgical outcomes has not been well studied. In this cohort study, investigators performed neurophysiologic characterization of stereo-electroencephalography ...

Quick Take: Assessment of the Safety of Pembrolizumab in Patients With HIV and Advanced Cancer—A Phase 1 Study

Immunotherapies such as anti-PD-1 (anti-programmed cell death 1) and anti-PD-L1 (anti-programmed cell death ligand 1) are effective in treating numerous malignancies. The safety and efficacy in patients who have both cancer and HIV, however, has not been well studied. In this non-randomized open-label trial, investigators treated 30 participants with advanced cancer and HIV with the […] ...

Saturday 15th June 2019

Quick Take: Image-guided Irreversible Electroporation of Localized Prostate Cancer: Functional and Oncologic Outcomes

There is a need for focal therapies for low to intermediate-risk prostate cancers, as whole-gland therapies have many complications without necessarily providing a survival benefit. Irreversible electroporation (IRE), a nonthermal ablative method based on forming nanoscale defects in cell membranes, has been proposed as a possible treatment. In this cohort study, investigators conducted IRE on [&#...

Lisinopril and carvedilol reduce cardiotoxicity in breast cancer patients receiving trastuzumab and anthracyclines

1. In this randomized, placebo controlled study of HER2-positive breast cancer patients receiving trastuzumab, use of preventative lisinopril or carvedilol did not significantly reduce cardiotoxicity compared to placebo. 2. For patients undergoing therapy with trastuzumab combined with anthracyclines, use of either carvedilol or lisinopril was associated with a reduced risk of cardiotoxicity compa...

Friday 14th June 2019

Activity limitations increase risk for mental health conditions

1. Youth aged 6 to 25 with chronic physical conditions were found to have more than 50% greater risk for developing mental health conditions on 2-year follow-up in a national survey. 2. Activity limitations mediated some of this risk, and were independently associated with increased risk for developing mental health conditions. Evidence Rating Level: 2 […] Source: 2 Minute Medicine

Thursday 13th June 2019

Quick Take: Diffusion Tensor MRI of White Matter of Healthy Full-term Newborns: Relationship to Neurodevelopmental Outcomes

Newborn babies have variations in white matter development, but it is unknown whether these variations are associated with changes in later neurodevelopment. In this prospective cohort study, investigators performed MRI examinations for 38 full-term infants at 2 weeks of age and then followed up at 2 years with the Bayley Scales of Infant Development (BSID) […] Source: 2 Minute Medicine

Wednesday 12th June 2019

Differences in presenting emergency department symptoms for inhaled vs edible cannabis use

1. The authors of this chart review observed that a greater proportion of visits attributed to cannabis use were related to inhaled use rather than ingestion. 2. Patients who were admitted with edible-related cannabis exposures were more likely to have cardiovascular symptoms and acute psychiatric events than patients admitted for inhaled-related cannabis exposures. Evidence Rating […] ...

Tuesday 11th June 2019

Blood transfusions from female, previously pregnant, or sex-discordant donors do not increase mortality

1. In this large retrospective cohort, there were no increases in mortality from red blood cell transfusions from female, previously pregnant, or sex-discordant donors. Evidence Rating Level: 2 (Good) Study Rundown: Recently, a few studies have suggested that blood donation from female donors, especially to male recipients, may result increased adverse events, such as transfusion-related […]...

Quick Take: Ultra-processed food intake and risk of cardiovascular disease

The consumption of ultra-processed food has increased substantially over the last several decades. These foods often have higher proportions of total and saturated fat, added sugar, energy density and salt, and lower proportions of fiber and vitamin density. Limited cross-sectional data has suggested associations with obesity, metabolic syndrome, functional gastrointestinal disorders, hypertension...

Monday 10th June 2019

Quick Take: Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans

Proton pump inhibitors (PPIs) are widely used in the management of gastroesophageal reflux. However, several studies have demonstrated serious adverse events associated with PPI use including cardiovascular disease, acute kidney injury, chronic kidney disease, dementia, pneumonia, gastric cancer, Clostridium difficile infection, and increased risk of fracture. Recent evidence has also suggested an...

Decline in pediatric herpes zoster associated with varicella vaccine

1. In a retrospective cohort study, researchers discovered that children vaccinated with the varicella vaccine were significantly less likely to have herpes zoster (HZ) than unvaccinated children. 2. Over the 12-year time period assessed, researchers found the overall rate of HZ decreased significantly, with the incidence among vaccinated children being lower than those who were […] Sou...

Sunday 9th June 2019

Quick Take: Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients

Protective intraoperative mechanical ventilation has been associated with reduced postoperative pulmonary complication risk. Obesity is associated with an increased risk of atelectasis and impaired respiratory function. In this setting, high positive end-expiratory pressure with alveolar recruitment maneuvers have been proposed for routine intraoperative mechanical ventilation to prevent these phy...

Quick Take: Low rates of specialized cancer consultation and cancer-directed therapy for noncurable pancreatic adenocarcinoma

Eighty percent of patients with advanced or metastatic pancreatic adenocarcinoma are not candidates for surgical resection and require noncurative therapy, including multi-agent chemotherapy regimens, radiation therapy, nerve blocks and other symptomatic relief modalities. Despite having established benefits for patients, a large proportion of pancreatic adenocarcinoma patients are unable to acces...

Saturday 8th June 2019

The MORDOR II trial: mass azithromycin distribution decreases childhood mortality in Niger

1. Mass, twice-yearly administration of azithromycin to children between 1 and 59 months of age in communities in Niger previously not administered azithromycin significantly reduced childhood mortality rates. 2. Communities given azithromycin for a third year, after receiving it the previous 2 years, had no significant change in childhood mortality rates. Evidence Rating Level: 1 […] S...

Friday 7th June 2019

The VADT-F trial: major cardiovascular events or death are not reduced in diabetics with intensive glucose control therapy

1. In a 15-year observational cohort study of type 2 diabetics treated with intensive compared to standard glucose control therapy the risk of major cardiovascular event or death was similar between both treatment groups. 2. There was no reported difference in health-related quality of life scores between the intensive and standard therapy groups. Evidence Rating […] Source: 2 Minute Me...

Thursday 6th June 2019

The CLL14 trial: longer progression-free survival for CLL patients with coexisting conditions treated with venetoclax

1. In untreated chronic lymphocytic leukemia (CLL) patients with coexisting conditions, patients treated with venetoclax–obinutuzumab experienced greater progression-free survival compared to patients treated with chlorambucil–obinutuzumab. 2. Rates of adverse events in the two treatment groups were similar. Evidence Rating Level: 1 (Excellent)   Study Rundown: Many patients with CLL are elde...

Better supporting the care needs of older adults with disabilities could reduce Medicare spending

1. The results of this observational study using data from the National Health and Aging Trends Study, indicate that older adults living with disabilities were in worse health compared to those without disabilities. 2. Participants with a disability who reported inadequate support at home were found to have higher median Medicare spending. Evidence Rating Level: […] Source: 2 Minute Med...

Wednesday 5th June 2019

#VisualAbstract: Frequency of Intracranial Hemorrhage With Low-Dose Aspirin in Individuals Without Symptomatic Cardiovascular Disease

1. In this systematic review and meta-analysis, use of low-dose aspirin in patients without symptomatic cardiovascular disease was linked with an increased risk of intracranial hemorrhage (ICH). 2. Risk of ICH was greatest amongst those with low body mass, or Asian ethnicity. Evidence Rating Level: 1 (Excellent)       Study Rundown: The use of low-dose aspirin for symptomatic […] ...

Neladenoson does not increase exercise capacity for heart failure with preserved ejection fraction

1. In this randomized controlled trial, heart failure with preserved ejection fraction (HFpEF) patients did not have improved exercise capacity with neladenoson versus placebo. 2. There were no changes in activity intensity, NT-proBNP level, high-sensitivity troponin T level, or quality of life with neladenoson. Evidence Rating Level: 1 (Excellent) Study Rundown: Heart failure with preserved [R...

Tuesday 4th June 2019

#VisualAbstract: Association of Unrecognized Obstructive Sleep Apnea With Postoperative Cardiovascular Events in Patients Undergoing Major Noncardiac Surgery

1. In this prospective cohort study, severe but not moderate, unrecognized obstructive sleep apnea was associated with increased postoperative cardiovascular events in patients undergoing major non-cardiac surgery. 2. Mean cumulative oxyhemoglobin desaturation less than 80% during the first 3 postoperative nights was longer in those with cardiovascular complications. Evidence Rating Level: 1 (Exce...

High rates of oophorectomy for benign ovarian neoplasms in pediatric population

1. In this multicenter retrospective cohort study, pediatric patients with an ovarian neoplasm had high rates of oophorectomy despite low rates of malignancy. Premenarchal status, clinical symptoms on presentation, concerning features on imaging, and having the surgery performed by an adult gynecologist or pediatric surgeon were all associated with increased rate of oophorectomy. 2. Researchers [&...

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