Latest Biotechnology, Pharmaceutical and Healthcare News from OncLive

14:06 EST 17th November 2018 | BioPortfolio

Here are the most relevant search results for "OncLive" found in our extensive news archives from over 250 global news sources.

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Showing News Articles 1–25 of 1,100+ from OncLive

Saturday 17th November 2018

Dabrafenib Plus Trametinib Demonstrates Activity in GI Cancers

The combination of dabrafenib and trametinib led to encouraging responses in patients with rare, incurable cancer of the digestive tract.

Friday 16th November 2018

Novel Agent Active Across Heavily Pretreated HER2+ Tumors

The novel bispecific antibody ZW25 induced a disease control rate of 82% in heavily pretreated patients across several HER2-positive tumor types, according to phase I study results presented at the 2018 EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium.

Capivasertib Effective in AKT-Mutated Cancers

The investigational AKT inhibitor capivasertib (AZD5363) demonstrated clinical activity in patients with AKT-mutated cancers, suggesting the validity of tailoring treatment to tumor genes. 

FDA Approves Frontline Eltrombopag for Severe Aplastic Anemia

The FDA has expanded the approval of eltrombopag in combination with standard immunosuppressive therapy to include newly diagnosed adult and pediatric patients 2 years and older with severe aplastic anemia.

Nivolumab/Ipilimumab Combo Nears EU Approval for Frontline RCC

The European Medicines Agency’s Committee for Medicinal Products for Human Use recommended approval of nivolumab combined with low-dose ipilimumab as a frontline treatment for patients with intermediate- and poor-risk advanced renal cell carcinoma.

Novel Drug Combination Shows Early Activity in Microsatellite Stable CRC

Pixatimod (PG545) in combination with the PD-1 inhibitor nivolumab (Opdivo) may benefit patients with advanced bowel cancers, including a small subset of those with colorectal cancer considered to be microsatellite stable.

Blinatumomab Approaches European Approval for MRD+ ALL

The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended approval of blinatumomab for the treatment of adult patients with B-cell precursor acute lymphoblastic leukemia who are in remission but still have minimal residual disease of at least 0.1%.

EU Panel Backs Expanding Ribociclib Approval in HR+/HER2- Breast Cancer

The European Medicine’s Agency Committee for Medicinal Products for Human Use has recommended expanding the approval of ribociclib (Kisqali) in women with HR+/HER2-negative breast cancer to include use in combination with fulvestrant (Faslodex). 

Durvalumab Combo Misses OS Endpoint in Frontline Metastatic NSCLC

The frontline combination of durvalumab (Imfinzi) and tremelimumab did not induce a statistically significant improvement in overall survival compared to standard chemotherapy in patients with metastatic non–small cell lung cancer.

FDA Approves Brentuximab Vedotin for Frontline CD30+ PTCL

The FDA has approved brentuximab vedotin for use in combination with chemotherapy for the frontline treatment of patients with CD30-expressing peripheral T-cell lymphoma.

Thursday 15th November 2018

Adjuvant Options Expand in HER2+ Breast Cancer, But Questions Remain

Vik Gorantla, MD, discusses ongoing developments in the adjuvant setting for patients with HER2-positive breast cancer.

Cabozantinib Approved in Europe for Second-Line HCC

The European Commission has approved cabozantinib (Cabometyx) for the treatment of patients with hepatocellular carcinoma who have been previously treated with sorafenib (Nexavar), according to Ipsen, which develops the multikinase inhibitor with Exelixis.

FDA Grants Brentuximab Vedotin Breakthrough Designation for Frontline CD30+ PTCL

The FDA has granted brentuximab vedotin a breakthrough therapy designation for use in combination with chemotherapy for the frontline treatment of patients with CD30-expressing peripheral T-cell lymphoma.

Expert Explains Treatment Approaches for MCL

Simon Rule, MD, PhD, discusses the observational and active therapeutic approaches for patients with mantle cell lymphoma. 

Addressing De-Escalation of Treatment in HER2+ Breast Cancer

Data from the NSABP B-52, PERSEPHONE, and APT trials have called into question the optimal duration of treatment for patients with HER2-positive breast cancer.

Novel Targeted Agents Emerging in Ovarian Cancer

Diana P. English, MD, discusses the promise for ADCs in the landscape of ovarian cancer treatment and targeting p53 mutations in patients with ovarian cancer.

Wednesday 14th November 2018

Epoetin Alfa Biosimilar Launched in United States at Discounted Cost

Epoetin alfa-epbx (Retacrit), the biosimilar to epoetin alfa (Procrit/Epogen) has been launched in the United States at a significant discount.

Neratinib Promising for Early-Stage HER2+ Breast Cancer, But Has Caveats

Mohammed Rahman, MD, discusses ongoing efforts to optimize the use of neratinib in patients with HER2-positive breast cancer.

Pegylated Doxorubicin/Carboplatin Plus Bevacizumab Improves PFS in Recurrent Ovarian Cancer

The combination regimen of pegylated liposomal doxorubicin with bevacizumab was found to significantly improve progression-free survival versus carboplatin/gemcitabine in select patients with recurrent ovarian cancer.  

New Approaches to Localized Prostate Cancer Combat Overtreatment

Mark Emberton, MD, FRCS, discusses updates in the diagnosis and treatment of patients with localized prostate cancer.

Future of MCL Treatment May Lie in Combinations, CAR T-Cell Therapy

Robert Dean, MD, discusses the promise for new therapies in mantle cell lymphoma.

Tuesday 13th November 2018

Long-Term Maintenance Olaparib Safe and Effective for Patients With Recurrent Ovarian Cancer

Long-term maintenance therapy with olaparib (Lynparza) tablets demonstrated a low rate of treatment discontinuation and tolerable safety profile in patients with platinum-sensitive recurrent ovarian cancer. 

Expert Explains Surgical Considerations in High-Risk Prostate Cancer

James Kearns, MD, discusses key issues to consider with surgery in patients with high-risk prostate cancer.

Enhanced Education Part of Successful Biosimilar Integration

Nancy Nixon, MD, discusses the retrospective study of the evolution of biosimilars in oncology, with a focus on trastuzumab and the path toward the integration of biosimilars into cancer care.

FDA Grants Atezolizumab Combo Priority Review for Frontline TNBC

The FDA has granted a priority review designation to a  supplemental biologics license application for the frontline combination of atezolizumab plus nab-paclitaxel for patients with unresectable locally advanced or metastatic PD-L1–positive triple-negative breast cancer.  

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