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"An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Trea∨derfield=date∨derval=DESC" News Stories

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Monday 22nd July 2019

The development of ALS may be modulated by the gut microbiome, according to a Nature report. The study is the first known report of a functional link between the microbiome and the neurodegenerative disease. https://go.nature.com/2XZjXxJ pic.twitter.com

The development of ALS may be modulated by the gut microbiome, according to a Nature report. The study is the first known report of a functional link between the microbiome and the neurodegenerative disease. https://go.nature.com/2XZjXxJ  pic.twitter.com/2yorOE52Ss


[Comment] Accelerated evolution and spread of multidrug-resistant Plasmodium falciparum takes down the latest first-line antimalarial drug in southeast Asia

The global fight against malaria has, over the decades, repeatedly been compromised by multidrug-resistant Plasmodium falciparum strains that first emerged in southeast Asia.1 Successively, these parasites have acquired resistance to chloroquine, sulphadoxine-pyrimethamine, mefloquine, and more recently the artemisinins through point mutations or amplification in genes (crt, dhps, dhfr, mdr1, and ...

[Articles] Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study

After emerging and circulating for several years within Cambodia, the P falciparum KEL1/PLA1 co-lineage diversified into multiple subgroups and acquired new genetic features, including novel crt mutations. These subgroups have rapidly spread into neighbouring countries, suggesting enhanced fitness. These findings highlight the urgent need for elimination of this increasingly drug-resistant parasit...


[Articles] Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

Dihydroartemisinin-piperaquine is not treating malaria effectively across the eastern Greater Mekong subregion. A highly drug-resistant P falciparum co-lineage is evolving, acquiring new resistance mechanisms, and spreading. Accelerated elimination of P falciparum malaria in this region is needed urgently, to prevent further spread and avoid a potential global health emergency.

ACADIA's pimavanserin misses main goal of Phase III study as adjunctive treatment in schizophrenia; shares fall http://bit.ly/2GofhqC  #pharma

ACADIA's pimavanserin misses main goal of Phase III study as adjunctive treatment in schizophrenia; shares fall http://bit.ly/2GofhqC  #pharma

Multidrug-resistant malaria spreading in Southeast Asia - study

Strains of malaria resistant to two key anti-malarial medicines are becoming more dominant in Vietnam, Laos and northern Thailand after spreading rapidly from Cambodia, scientists warned on Monday.

Antibiotic use without prescription common in U.S.

(Reuters Health) - Many people in the U.S. take antibiotics that weren't prescribed for them, according to a new study that highlights one factor that may be contributing to the rise of antibiotic resistant infections.

FNR funds an additional 6 million euros for Luxembourg Parkinson's study

In spring 2015, the National Centre for Excellence in Research on Parkinson's Disease was created as the very first inter-institutional research program of its kind in Luxembourg.

Cognitive-Behavioral Therapy for Internet Addiction

A targeted approach improved symptoms, time spent online, and psychosocial functioning in a group of young men.

Online pain and mood symptom self-management works better when coupled with clinician telecare

Pain is the most common physical symptom for which adults seek medical attention in the United States, while anxiety and depression are the most common mental health symptoms for which adults visit a doctor. Drugs, especially opioids, may not be the only or best therapy.

Malaria Parasites in Southeast Asia Largely Resistant to Newest First-Line Treatment

Strains of Plasmodium falciparum in southeast Asia have become resistant to yet another first-line treatment for malaria — dihydroartemisinin plus piperaquine. A study in the...

Study will investigate how to make talk therapy treatment more accessible to all women

Depression and anxiety during and after a pregnancy is the most common complication associated with having a child.

Many Americans mistakenly use aspirin to prevent heart disease

(Reuters Health) - - Many Americans regularly take aspirin without a doctor's recommendation, believing it will protect their hearts, a new study finds. The problem is that for those who don't already have heart disease, aspirin comes with some dange...

Acadia's schizophrenia treatment fails to meet main goal of late-stage study

Acadia Pharmaceuticals Inc said on Monday its add-on treatment for schizophrenia failed to meet the main goal in a late-stage study.

Millions should stop taking aspirin for heart health, study says

Some 29 million people 40 and older were taking an aspirin a day despite having no known heart disease in 2017.

Study: Millions should stop using aspirin for heart health

Millions of people who take aspirin to prevent a heart attack may need to rethink the pill-popping, Harvard researchers say.

Gay Men's Specialist Psychotherapist, Sex Therapist, and Life Coach Launches Podcast, "Gay Therapy LA with Ken Howard, LCSW"

Ken Howard, LCSW, a licensed psychotherapist in California (Licensed Clinical Social Worker) with over 27 years experience as an LGBT-affirmative therapist, sex therapist, and life/career/relationship coach in general, and gay men's specialist in particular, announces his new podcast, "Gay Therapy LA with Ken Howard, LCSW", giving tips on quality of life improvement from a gay-affirm...

Electronic Submission of Adverse Event Reports to FDA Adverse Event Reporting System (FAERS) using International Council for Harmonisation (ICH) E2B(R3) Standards - 02/19/2020 - 02/19/2020

The purpose of these public meetings is to provide the pharmaceutical industry and other interested parties with information on the plans, progress, and technical specifications to upgrade electronic submission standards for the premarket and postmarket safety surveillance programs managed by CDER and CBER

HealthStream Announces Second Quarter 2019 Results

HealthStream, Inc. (Nasdaq: HSTM), a leading provider of workforce and provider solutions for the healthcare industry, announced today results for the second quarter ended June 30, 2019. In this earnings release, all results are from continuing operations only, unless otherwise indicated (i.e., results for the three and six months ended June 30, 2019 and 2018 exclude the gain on the sale of our d...

RMS Medical Products Schedules 2019 Second Quarter Financial Results and Conference Call

Repro Med Systems, Inc. dba RMS Medical Products (OTCQX: REPR) today announced that it will release its financial results for the second quarter and six months ended June 30, 2019 after the close of the financial markets on Tuesday, August 6, 2019. Management will host a conference call on Wednesday, August 7, 2019 at 9:00 am ET to discuss the results and business activities. Interested parties...

ACADIA Pharmaceuticals Announces Top-line Results from Phase 3 ENHANCE Trial of Pimavanserin as Adjunctive Treatment for Patients with Schizophrenia

- Pimavanserin did not achieve statistical significance on the primary endpoint, but showed a consistent trend in improvement of psychotic symptoms (p=0.0940) - Significant improvements observed on secondary endpoint of PANSS negative symptoms scale sub-score (unadjusted p=0.0474) - Conference call and webcast to be held today at 5:00 p.m. Eastern Time ACADIA Pharmaceuticals Inc. (Nasdaq: AC...

Children’s Hospital Los Angeles Receives $1.7M to Study How GI Tract Repairs After Injury

Chemotherapy and radiation target cancer cells but these treatments produce unwanted side effects on healthy tissue. The intestines are particularly sensitive to this toxicity. A better understanding of how intestinal tissue repairs itself in response to injury could help medicine develop ways to minimize these and other off-target effects. Children’s Hospital Los Angeles investigator Mark Frey...

Pact Pharma enrolls first patients in Phase Ia/Ib solid tumor cell therapy study

The company’s product is a T-cell receptor therapy, or TCR. While TCRs have been restricted by genotype, Pact says it has engineered its cells to overcome that restriction.

Smoking Has Long-Term Impact on Peripheral Artery Disease Risk

MONDAY, July 22, 2019 -- Both duration and intensity of smoking have a long-term impact on the risk for three major atherosclerotic diseases: peripheral artery disease (PAD), coronary heart disease (CHD), and stroke, according to a study published...

Multidrug-resistant malaria spreading in Southeast Asia: study

Strains of malaria resistant to two key anti-malarial medicines are becoming more dominant in Vietnam, Laos and northern Thailand after spreading rapidly from Cambodia, scientists warned on Monday.


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