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Here are the most relevant search results for "Cell Signaling Technologies" found in our extensive news archives from over 250 global news sources.
In addition to our news stories we have dozens of PubMed Articles about Cell Signaling Technologies for you to read. Along with our medical data and news we also list Cell Signaling Technologies Clinical Trials, which are updated daily. BioPortfolio also has a large database of Cell Signaling Technologies Companies for you to search.
Expression of the B-cell antigen receptor (BCR) is essential not only for the development but also for the maintenance of mature B cells. Similarly, many B-cell lymphomas, including Burkitt lymphoma (BL), require continuous BCR signaling for their tumor growth. This growth is driven by immunoreceptor tyrosine-based activation motif (ITAM) and PI3 kinase (PI3K) signaling. Here, we employ CRISPR/Cas...
Cells need for reactions on environmental changes and a balanced system of signaling cascades within the cell. Proteins outside of the cell, on the cellular surface, inside the cellular membrane, and within the cell orchestrate many fine-tuned signaling pathways, which result in adequate reactions on the environmental conditions or changes in the organism itself.
The first known immortalized cell line with a naturally-occurring inactivating mutation in PRKAR1A, the regulatory subunit type 1A (R1alpha) of protein kinase A (PKA), which is associated with tumor formation.Read more about Human Cell Line for Studies on Signaling and Endocrine Cancer
The mammalian Hippo signaling pathway, through its effectors YAP and TAZ, coerces epithelial progenitor cell expansion for appropriate tissue development or regeneration upon damage. Its ability to drive rapid tissue growth explains why many oncogenic events frequently exploit this pathway to promote cancer phenotypes. Indeed, several tumor types including basal cell carcinoma (BCC) show genetic a...
The quality of a cell signal, not just its strength, can determine whether a cell will follow a path toward cancer. This finding, which emerged from optogenetic interrogations of both healthy cells and cancer cells, stresses the importance of signal timing, or rather, the ability of cells to “hear” signals distinctly enough to respond appropriately. Unfortunately, mutations that affect signali...
(Georgia Institute of Technology) Using an informatics tool that identifies "hotspots" of post-translational modification (PTM) activity on proteins, researchers have found a previously-unknown mechanism that puts the brakes on an important cell signaling process involving the G proteins found in most living organisms.
NewsResearch into cell-to-cell signaling mechanism may lead to new cancer treatments.
In this exclusive interview, Fintan Walton talks to Peter Mountford, formerly CEO of Stem Cell Sciences, about the current state of stem cell technologies and their potential healthcare and research applications. The company is now at the ‘end of the beginning stage’, and has the capability to mass produce stem cells, with which it hopes to provide a range of products and services. The impact ...
In this episode of PharmaTelevision News Review, Fintan Walton talks with Dr Paul Tan, CEO of Living Cell Technologies. Filmed at AusBiotech 2009, they discuss: • The company’s origins and aims • Pig islet transplantation to combat diabetes • Results of Russian and New Zealand clinical trials • Living Cell Technologies’ issues with clinical trials in Australia • The company’s searc...
Death receptor 6 (DR6) is an orphan member of the TNF receptor superfamily and controls cell death and differentiation in a cell-autonomous manner in different cell types. Here, we report an additional non-cell-autonomous function for DR6 in the peripheral nervous system (PNS). DR6-knockout (DR6 KO) mice showed precocious myelination in the PNS. Using an in vitro myelination assay, we demonst...
Cell–cell and cell–matrix interactions guide organ development and homeostasis by controlling lineage specification and maintenance, but the underlying molecular principles are largely unknown. Here, we show that in human developing cardiomyocytes cell–cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA-ROCK signaling to m...
A study conducted by researchers from The Sainsbury Laboratory, the University of Zurich, and the University of Washington has identified the mechanisms by which a common plant co-receptor can regulate many different signaling pathways through protein phosphorylation that the researchers call a ‘phosphocode'. Cell-surface receptors are important to...
The first known immortalized cell line with a naturally-occurring inactivating mutation in PRKAR1A, the regulatory subunit type 1A (R1alpha) of protein kinase A (PKA), which is associated with tumor formation.Read more about A Novel Immortalized Human Adrenal Cell Line with Inactive Protein Kinase A for Studies on cAMP Signaling and Endocrine Tumorigenesis
(Vienna University of Technology) With a standard electron microscope, only dead T cells can be studied. Therefore, it is very hard to figure out the inner workings of the cell. New microscopy techniques, making it possible to study living T cells, have now led to surprising results: while it has been generally believed that T cell receptors must interact with one another for effective immune-sign...
Researchers at TU Wien and the Vienna School of Medicine report that T-cell receptors act alone, rather than interact with one another, for effective immune signaling. Their study (“ Monomeric TCRs drive T cell antigen recognition ”) appears in Nature Immunology . “T-cell antigen recognition requires T cell antigen receptors (TCRs) engaging MHC-embedded antigenic peptides (pMH...
Scientists in Germany have discovered that colon cancers contain two different cell types, characterized by mitogen-activated protein kinase (MAPK) and NOTCH signaling, respectively, which can regenerate each other when one type is killed by a targeted therapeutic. The studies, headed by David Horst, Ph.D., at the Charité University Hospital in Berlin, suggest that this cell plasticity allow...
Lesson 9 Cell Signaling: Curations and Articles of reference as supplemental information for lecture section on WNTs: #TUBiol3373 Stephen J. Wiilliams, Ph.D: Curator The following contain curations of scientific articles from the site https://pharmaceuticalintelligence.com intended as additional reference material to supplement material presented in the lecture. Wnts are a family of lipid-mo...
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study of the effects of spaceflight on the development of heart cells identified changes in calcium signaling that could be used to develop stem cell-based therapies for cardiac repair.
When a RAS gene operates normally, it acts as an on/off switch for cell signaling to control cell proliferation. But when the gene mutates, the switch jams into the "on" position, allowing cells to proliferate uncontrollably.