Evaluation of the Tumor Microenvironment Using Image Analysis for Clinical Trials, New Webinar Hosted by Xtalks

19:00 EST 27 Feb 2017 | Marketwired

TORONTO, ON--(Marketwired - February 28, 2017) - The number of clinical trials examining immunotherapy and combination therapies with immunotherapy as a backbone has exceeded 1000 in 2016. While PD-L1 by immunohistochemistry has been successfully employed as a companion diagnostic for several therapies across a handful of indications, PD-L1 is only one potential biomarker for showing a predictive response. PD-L1 does not provide a complete depiction of the tumor and it is widely documented that some PD-L1 negative patients have responded positively to immunotherapy. As more combination therapies are examined, more informative markers will need to guide when and how a treatment or combinations of treatment should be considered.

Recently, efforts have focused on the tumor microenvironment as an indicator of response to immunotherapy. Specifically, "hot" tumors with involvement of the immune system have been suggested to have a statistically higher response to treatment protocols. While some have focused on the inflammatory gene panels and mutational burden, adequately assessment of various types of T cell responders in the tumor could provide insight into a patient's prognosis. The environmental makeup remains extremely complex, with some cells enhancing immunosuppression and others inducing potent anti-tumor responses. Furthermore, evaluation of proximity and morphology of the differing types of T cells will be critical in assessing the status of the existing immune involvement.

In the case of standard immunohistochemistry, the challenge in assessment lies within the inherent semi-quantitative analysis output. Manual pathology assessment of a single IHC marker is constrained by the intensity and percent of cells stained. Additionally, standardization and reproducibility remain a challenge in the clinical trial setting. Conversely, immunohistochemistry allows for the evaluation of differential expression among the heterogeneity of the sample by which no other testing modality is suitable. Employing image analysis and machine learning from analytics software such as Definiens allows for standardization of the data captured for a given marker; thereby making the analysis of the marker under study more robust and powerful.

In the current example, a standard IHC marker is assessed and Definiens is to develop an enumeration algorithm to assess the overall intensity of the marker as well as the density of the marker in the tumor region (reported in cells/mm2.). Subsequent validation shows the correlation of the analysis using the software compared with the manual assessment meets the preset criteria. Furthermore, the repeatability of the assay when using image analysis consistently meets criteria significantly better than manual assessment. Overall, the employment of image analysis for any given marker helps to improve pathology assessments and standardizes interpretation as well as systematically identifies the optimal cut-point threshold.

To learn more about this complimentary event visit: Evaluation of the Tumor Microenvironment Using Image Analysis for Clinical Trials

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners (from pharmaceutical & biotech companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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Contact:Dian RazakTel: +1 (416) 977-6555 ext 352Email: NEXT ARTICLE

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