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Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

19:00 EST 6 Mar 2017 | Arthritis Research and Therapy

The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthri...

Original Article: Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

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