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BASEL, Switzerland and CAMBRIDGE, Mass., March 10, 2017 (GLOBE NEWSWIRE) -- CRISPR Therapeutics, (NASDAQ:CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, today reported financial results for the three months and full year-ended December 31, 2016 and provided a business update.
“2016 was a year of tremendous growth for CRISPR Therapeutics, with the successful IPO in October certainly being a highlight,” said Dr. Rodger Novak, CEO of CRISPR Therapeutics. “It is very rewarding to see the significant achievements accompanied by a rapid maturation of the company since the founding of CRISPR in late 2013. The skill and dedication of our employees is remarkable and constitutes a key basis for delivering on the promise of CRISPR/Cas9 gene editing to create transformative gene-based medicines for serious human diseases.”
Recent Highlights and Outlook
Fourth Quarter and Full Year 2016 Financial Results (U.S. GAAP)
As of December 31, 2016, CRISPR Therapeutics had $315.5 million in cash as compared to $156.0 million in cash as of December 31, 2015. Based on its current operating plan, CRISPR expects that its existing cash resources will enable it to fund operating expenses and capital expenditure requirements for at least the next two years.
Three Months Ended December 31, 2016
CRISPR Therapeutics reported net income of $17.1 million in the three months ended December 31, 2016 as compared to a net loss of $12.3 million for the three months ended December 31, 2015. The increase in net income of $29.4 million was primarily a result of an increase in loss from operations of $13.1 million and a loss from equity method investment of $35.8 million offset by other income recognized in connection with the formation of a joint venture with Bayer of $78.6 million.
Research and development expenses were $15.6 million for the three months ended December 31, 2016 as compared to $6.2 million for the three months ended December 31, 2015. The increase in research and development expenses for the fourth quarter was primarily driven by increased spending on costs used to advance CRISPR’s pre-clinical and drug discovery activities, in addition to increased salary and related benefits costs due to the increase in employee headcount.
General and administrative expenses were $12.1 million for the three months ended December 31, 2016 as compared to $6.2 million for the three months ended December 31, 2015. The increase in general and administrative expenses in the fourth quarter was primarily due to an increase in employee related costs to support our overall growth, including stock-based compensation expense, intellectual property costs incurred to prosecute our patents and costs related to an interference proceeding with respect to our in-licensed intellectual property.
The Year Ended December 31, 2016
CRISPR Therapeutics reported a net loss of $23.2 million for the year ended December 31, 2016 as compared to $25.8 million for the year ended December 31, 2015. The decrease in the net loss of $2.6 million was primarily a result of an increase in loss from operations of $42.4 million and a loss from equity method investment of $36.5 million offset by an increase in other income of $82.0 million primarily related to the formation of the joint venture with Bayer.
Research and development expenses for the year ended December 31, 2016 were $42.2 million as compared to $12.6 million for the year ended December 31, 2015. The increase in research and development expenses for the full year was primarily driven by increased spending on costs used to advance CRISPR’s pre-clinical and drug discovery activities, as well as increased salary and related benefits costs due to the increase in employee headcount.
General and administrative expenses were $31.1 million for the year ended December 31, 2016 as compared to $13.4 million for the year ended December 31, 2015. The increase in general and administrative expenses in the full year was primarily due to an increase in employee related costs to support our overall growth, including stock-based compensation expense, intellectual property costs incurred to prosecute our patents and costs related to an interference proceeding with respect to our in-licensed intellectual property.
About CRISPR Therapeutics
CRISPR Therapeutics is a leading gene-editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 gene-editing platform. CRISPR/Cas9 is a revolutionary technology that allows for precise, directed changes to genomic DNA. CRISPR's multi-disciplinary team of world-class researchers and drug developers is working to translate this technology into breakthrough human therapeutics in a number of serious diseases. Additionally, CRISPR Therapeutics has established strategic collaborations with Bayer and Vertex Pharmaceuticals to develop CRISPR-based therapeutics in diseases with high unmet need. The foundational CRISPR/Cas9 patent estate for human therapeutic use was licensed from the company's scientific founder Emmanuelle Charpentier, Ph.D. CRISPR Therapeutics is headquartered in Basel, Switzerland with its R&D operations based in Cambridge, Massachusetts. For more information, please visit www.crisprtx.com.
CRISPR Forward-Looking Statement
Certain statements set forth in this press release constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, but not limited to, statements concerning: the therapeutic value, development, and commercial potential of CRISPR/Cas-9 gene editing technologies and therapies and the intellectual property protection of our technology and therapies. You are cautioned that forward-looking statements are inherently uncertain. Although the company believes that such statements are based on reasonable assumptions within the bounds of its knowledge of its business and operations, the forward-looking statements are neither promises nor guarantees and they are necessarily subject to a high degree of uncertainty and risk. Actual performance and results may differ materially from those projected or suggested in the forward-looking statements due to various risks and uncertainties. These risks and uncertainties include, among others: uncertainties regarding the intellectual property protection for our technology and intellectual property belonging to third parties; uncertainties inherent in the initiation and conduct of preclinical and clinical studies for the company’s product candidates; availability and timing of results from preclinical and clinical studies; whether results from a preclinical study or clinical trial will be predictive of future results in connection with future trials or use; expectations for regulatory approvals to conduct trials or to market products; and those risks and uncertainties described under the heading “Risk Factors” in the company’s most recent annual report on Form 10-K, and in any other subsequent filings made by the company with the U.S. Securities and Exchange Commission (SEC), which are available on the SEC’s website at www.sec.gov. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date they are made. The information contained in this press release is provided by the company as of the date hereof, and, except as required by law, the company disclaims any intention or responsibility for updating or revising any forward-looking information contained in this press release.
|CRISPR Therapeutics AG|
|Consolidated Statements of Operations|
|In thousands except share data and per share data|
|Three Months Ended||Twelve Months Ended|
|December 31,||December 31,|
|Research and development||15,572||6,174||42,238||12,573|
|General and administrative||12,082||6,239||31,056||13,403|
|Total operating expenses||27,654||12,413||73,294||25,976|
|Loss from operations||(25,310||)||(12,166||)||(68,130||)||(25,729||)|
|Other income (expense), net||78,654||(50||)||70,462||(92||)|
|Loss from equity method investment||(35,846||)||-||(36,532||)||-|
|Gain on extinguishment of convertible loan||-||-||11,482||-|
|Net income (loss) before income taxes||17,498||(12,216||)||(22,718||)||(25,821||)|
|Provision for income taxes||(400||)||(70||)||(484||)||(7||)|
|Net income (loss)||17,098||(12,286||)||(23,202||)||(25,828||)|
|Loss attributable to noncontrolling interest||1||16||25||325|
|Dividends attributable to Redeemable Convertible Preferred Stock||(763||)||-||-||-|
|Net income allocated to participating securities||(2,299||)||-||-||-|
|Net income (loss) attributable to common stockholders||$||14,037||$||(12,270||)||$||(23,177||)||$||(25,503||)|
|Net income (loss) per share attributable to common shareholders:|
|Weighted-average common shares outstanding used in net income (loss) per share attributable to common shareholders:|
|CRISPR Therapeutics AG|
|Consolidated Balance Sheets Data|
|As of December 31,|
|Redeemable convertible preferred shares||-||64,521|
|Total shareholders' equity (deficit)||232,846||(29,124||)|
MEDIA CONTACTS: Jennifer Paganelli W2O Group for CRISPR 347-658-8290 firstname.lastname@example.org INVESTOR CONTACT: Chris Brinzey Westwicke Partners for CRISPR 339-970-2843 email@example.comNEXT ARTICLE
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