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Delivering drugs to the brain is no easy task. The blood-brain barrier -a protective sheath of tissue that shields the brain from harmful chemicals and invaders - cannot be penetrated by most therapeutics that are injected into a person's blood stream. But for treating diseases of the central nervous system and cancers such as glioblastoma, it's essential to get drugs across this barrier and deliver them to where they are needed most. Current research models that are used to study or imitate the blood-brain barrier have a number of limitations. Investigators at Brigham and Women's Hospital have developed an innovative but easily implemented approach that uses "spheroids" to mimic the blood-brain barrier more accurately, and appears to overcome several challenges for discovering and advancing new drugs for treating brain conditions. They report their results June 6 in Nature Communications.
Original Article: Building a better blood-brain barrier modelNEXT ARTICLE
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