BMS, Novartis to Study Combination Therapies for Colorectal Cancer

05:32 EDT 6 Jun 2017 | Genetic Engineering News

Bristol-Myers Squibb (BMS) will carry out a Phase I/II study assessing both its Opdivo ® (nivolumab) and its Opdivo + Yervoy ® (ipilimumab) regimen in combination with Novartis’ Mekinist ® (trametinib) in metastatic colorectal cancer. The clinical research collaboration—whose value was not disclosed—will entail a study of the safety, tolerability, and efficacy of the combinations in patients with microsatellite stable tumors, where the tumors are proficient in mismatch repair (MSS mCRC pMMR). BMS will conduct the study and is expected to establish recommended dose regimens as well as the preliminary anti-tumor activity of the combination therapies. BMS and Novartis plan to evaluate the results to determine optimal approaches and determine potential clinical development of these combinations. The study marks an expansion of an ongoing partnership by the two pharma giants, launched in 2014 and initially focused on combining cancer treatments of the companies in order to ...

Original Article: BMS, Novartis to Study Combination Therapies for Colorectal Cancer


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