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Discovery of New Immune Cell May Improve Treatment of Lung Cancer Patients

07:11 EDT 19 Jun 2017 | Genetic Engineering News

An international research team says it has discovered a new kind of immune cell that could predict which lung cancer patients will benefit most from immunotherapy treatment. The group's study ("Tissue-Resident Memory Features Are Linked to the Magnitude of Cytotoxic T Cell Responses in Human Lung Cancer") appears in Nature Immunology . Investigators at the University of Southampton and the La Jolla Institute for Allergy & Immunology found that lung cancer patients with large amounts of a particular type of immune T cell, called tissue-resident memory T cells, in their tumor were 34% less likely to die. The team also found that it was not just the numbers of cells that increased survival, but also the cells’ behavior played a key role. The cells clustered together and took up residency in a particular tissue, in this case the cancer tissue, to protect the patient. These new ...

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