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Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

17:31 EDT 19 Jun 2017 | Nature Publishing

A protocol based on chemical modulation of WNT activity is used to efficiently generate colonic organoids that recapitulate the molecular features of human colon tissue. Colonic organoids generated from induced pluripotent stem cells from patients with familial adenomatous polyposis provide an in vitro platform for disease modeling and preclinical drug testing.

Original Article: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

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