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[Comment] Identifying modifiers of Huntington's disease progression

20:15 EDT 19 Jun 2017 | The Lancet

Researchers are now harvesting the first fruits of their labour from nearly two decades of tremendous efforts to track progression of Huntington's disease in the manifest and premanifest phases. Large observational studies such as PREDICT-HD,1 COHORT,2 REGISTRY,3 and TRACK-HD4 have aimed to find objective measures of disease progression and learn about the course of the disease. The work to measure disease progression is ongoing. The global, observational study ENROLL-HD5 is currently recruiting and is intended to become the largest study of Huntington's disease.

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Huntington's Disease
Huntington's disease is a hereditary disease caused by a defect in a single gene on Chromosome 4 that is inherited in an autosomal dominant fashion. The defect causes a part of DNA, called a CAG repeat, to occur many more times than it is supposed to...