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[Articles] Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

20:15 EDT 19 Jun 2017 | The Lancet

The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation.

Original Article: [Articles] Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

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