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[Comment] Which fractionation of radiotherapy is best for limited-stage small-cell lung cancer?

07:28 EDT 20 Jun 2017 | The Lancet

The role of radiotherapy in the treatment of small-cell lung cancer has been established through a series of clinical trials and meta-analyses during the past 20 years, which showed that local radiotherapy in addition to chemotherapy1 and whole-brain radiotherapy2 can improve patient prognosis. Moreover, use of radiotherapy with concurrent chemotherapy3 in the early stages of disease has been shown to further improve treatment outcomes. Results from the Intergroup 0096 trial4 showed that a radiotherapy dose of 45 Gy given twice daily led to improved prognosis when compared with once-daily fractionation regimens employing the same total radiotherapy dose.

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