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Glucagon receptor blockade may reduce insulin dose requirement in type 1 diabetes

17:30 EDT 14 Jun 2017 | Healio

SAN DIEGO — A single dose of an investigational agent that blocks glucagon receptors can lower the amount of insulin needed and improve glucose levels without increased hypoglycemia in adults with type 1 diabetes, according to a presenter here. “In humans with type 1 diabetes, it is well-known that glucagon is dysregulated,” said Jeremy Pettus, MD, assistant professor of medicine in the department of endocrinology at the University of California, San Diego. “For multiple reasons, people with type 1 diabetes produce too much glucagon, which can increase sympathetic glucose output and make people have profound issues with hyperglycemia. The concept we were going to test is basically, can we use this concept that’s been proven in animal models in individuals with type 1 diabetes?”

Original Article: Glucagon receptor blockade may reduce insulin dose requirement in type 1 diabetes

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