eFFECTOR, Pfizer, Merck KGaA Partner to Combine Avelumab with MNK1/2 Inhibitor

06:32 EDT 20 Jun 2017 | Genetic Engineering News

eFFECTOR Therapeutics, Pfizer, and Merck KGaA established a partnership to carry out Phase II study evaluating the safety, tolerability, and efficacy of eFFECTOR’s small-molecule investigational MNK1/2 (MAP kinase-interacting kinase 1 and 2) inhibitor eFT508 combined with Merck KGaA’s and Pfizer’s programmed death-ligand 1 (PD-L1) antibody avelumab (Bavencio ® ) in patients with microsatellite-stable relapsed or refractory colorectal cancer (CRC). eFFECTOR will conduct the noncomparative study, which is projected to start during the third quarter of this year, and will also include an eFT508 montherapy arm. Pfizer and Merck KGaA will share associated trial costs.  "We believe eFT508, our lead program, is a promising new immuno-oncology drug candidate that could significantly improve patient response in combination with checkpoint inhibitors," said Steve Worland, Ph.D., president and CEO at eFFECTOR. "We look forward to exploring the potential of this novel combination and the role we hope it may eventually ...

Original Article: eFFECTOR, Pfizer, Merck KGaA Partner to Combine Avelumab with MNK1/2 Inhibitor


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