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Nonreproducibility of Preclinical Research

20:00 EDT 19 Jun 2017 | JAMA

To the Editor In his Viewpoint, Dr Ioannidis highlighted the seriousness of the nonreproducibility of preclinical research and suggested various ways to improve the situation. Two points are of concern. First, he wrote that “Overall, basic and preclinical research probably have a much larger challenge of nonreproducibility than clinical research.” The reverse is more likely to be true. Clinical research may be infeasible to reproduce for at least 2 reasons: the cost of doing so may be prohibitive and both background and foreground conditions may be impossible to replicate adequately.

Original Article: Nonreproducibility of Preclinical Research

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