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T cells from patients with Parkinson’s disease recognize α-synuclein peptides

17:25 EDT 21 Jun 2017 | Nature Publishing

Genetic studies have shown the association of Parkinson’s disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson’s disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson’s disease. These responses may explain the association of Parkinson’s disease with specific major histocompatibility complex alleles.

Original Article: T cells from patients with Parkinson’s disease recognize α-synuclein peptides

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