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Motif Bio medical chief to present at prestigious infectious diseases conference

03:24 EDT 22 Jun 2017 | Proactive Investors

Motif Bio Plc (LON:MTFB) said its chief medical officer has been invited to address a prestigious conference to discuss the results of the first of two clinical trials of iclaprim, its next-generation antibiotic. Dr David Huang will present at IDWeek 2017 on October 7 where he will give an overview of the REVIVE-1 phase-III clinical study. "IDWeek is a major event for infectious disease professionals and I am delighted that the IDWeek Committee have selected iclaprim for presentation,” said Huang. “I look forward to presenting the positive data from the REVIVE-1 trial.  “We believe these data suggest iclaprim may serve as an important differentiated antibiotic option in an era of emerging antibiotic resistant infections." Positive result In April Motif successfully completed the final-stage assessment of the drug and its ability to treat patients with acute bacterial skin and skin structure infections (ABSSSI). The top-line results revealed it scored well against one of the leading products, vancomycin, on two counts. Researchers were assessing whether iclaprim was ‘non-inferior’ to vancomycin in the 48 to 72 hours after the start of administration and at the test of cure, a week to a fortnight after patients stop receiving treatment. It also did well in meeting several secondary ‘endpoints’, investors were told. Kidney disease boost Data from REVIVE-2, the second phase III trial, which uses an identical protocol but has different trial centres, are expected in the second half of the year. Motif plans to make a new drug application in the first half of 2018. It is thought iclaprim could be an important treatment for patients with ABSSSI who may have kidney disease – which is around a quarter of the 3.6mln annually that catch the infection.

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