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Brain Protein Finding May Offer Insights into Neuro-Disease Development

04:26 EDT 22 Jun 2017 | Genetic Engineering News

Scientists at the University of Texas Medical Branch at Galveston say they have gained a better understanding of how the developing brain ensures that connections between brain cells reach their intended destination while also being maintained during life-span. The team reported its findings (“The glycosylation pathway is required for the secretion of Slit and for the maintenance of the Slit receptor Robo on axons”) in Science Signalling. The brain contains regions that serve specific functions such as interpreting sensory information, controlling bodily movement or formation of memory, and so on. In order for regions to interact with one another to perform complex tasks, the brain has a web of interconnecting pathways. Krishna M. Bhat, Ph.D., UTMB professor in the department of neuroscience and cell biology, and his colleagues demonstrated that a protein called Slit is necessary for maintaining the interconnecting pathways in the nervous system. Without Slit, ...

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