Crohn’s Disease Severity Amplified by Fungus

06:27 EDT 22 Jun 2017 | Genetic Engineering News

Inflammatory bowel disease (IBD) affects millions worldwide and can often lead to serious intestinal disorders if left unchecked. While there has been a wave of IBD drugs that have recently come to market, the underlying molecular mechanisms for many of these disorders remains a mystery. Now, a team of researchers at Case Western Reserve University (CWRU) School of Medicine recently presented new data at the Digestive Disease Week conference in Chicago showing that the fungus Candida tropicalis triggers gut inflammation and exacerbates symptoms of Crohn's disease. Data from the study were presented in a talk entitled “Infection with the Fungus Candida Tropicalis Significantly Increases the Severity of Colitis in C57bl/6 Mice.” "The type of microorganisms that live in our intestine, our microbiome, has been shown to be a key element for triggering Crohn's disease,” explained lead study investigator Luca Di Martino, Ph.D., a postdoctoral research fellow in ...

Original Article: Crohn’s Disease Severity Amplified by Fungus


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Crohn’s disease (CD) is a long-term condition that causes inflammation of the lining of the digestive system.  Inflammation can affect any part of the digestive system, from the mouth to the back passage, but most commonly occurs in the last s...

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