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snoRNAs contribute to myeloid leukaemogenesis

11:09 EDT 29 Jun 2017 | Nature Publishing

The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.

Original Article: snoRNAs contribute to myeloid leukaemogenesis

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