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OPA1 and cardiolipin team up for mitochondrial fusion

11:09 EDT 29 Jun 2017 | Nature Publishing

Fusion between the inner membranes of two mitochondria requires the GTPase optic atrophy 1 (OPA1), but the molecular mechanism is poorly understood. A study now shows that fusion of two liposomes can be performed by OPA1 tethered to just one liposome, through an interaction with the phospholipid cardiolipin on the opposing liposome.

Original Article: OPA1 and cardiolipin team up for mitochondrial fusion

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