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O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency

11:09 EDT 29 Jun 2017 | Nature Publishing

Wang et al. show that glucose deprivation causes AMPK-dependent phosphorylation of fumarase leading to ATF2 binding and gene transcription for cell cycle arrest. In cancer cells O-GlcNAcylation of fumarase blocks ATF2 binding to allow proliferation.

Original Article: O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency

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