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Identification of Colorectal Cancer Biomarkers by Serum Protein Profiling

19:00 EST 1 Dec 2009 | NIH

This invention describes serum features that distinguish colorectal carcinoma malignant patient samples versus healthy samples using surface-enhanced laser desorption ionization time-of-flight (SELDI-TOF) mass spectrometry. By comparing healthy versus malignant samples, the investigators were able to identify thirteen (13) serum features that have been validated using an independently collected, blinded validation set of 55 sera samples. The features are characterized by the mass to charge ratio (m/z ratio). The investigators have shown that SELDI-TOF based serum marker protein profiling enables minimally invasive detection of colon cancer with 96.7 percent sensitivity and 100 percent specificity.

Colorectal cancer is the third most common cancer and the third leading cause of cancer-related mortality in the United States. Current diagnostic methods for colorectal cancer have a large non-compliance rate because of discomfort, e.g., sigmoidoscopy or colonoscopy, or have a high rate of false positive results, e.g., fecal occult blood tests. The claimed invention has the potential to be a widely used, easy-to-use, and inexpensive diagnostic.

IC: 
NCI
NIH Ref. No.: 
E-106-2005/0
TAB No: 
TAB-1300
Provider Technology ID: 
1300
Updated On: 
Jun 23, 2017
Date Published: 
Wednesday, December 2, 2009
Provider Classifications: 
Patent Application: 
60/664,681
PCT/US2006/010624
11/886,886
Publications: 
Patent Authority: 
US
PCT
US
2017-06-29 00:00:00
2017-06-29 00:00:00
Patent Number: 
9,075,062
Licensing Contacts: 
LPM Address: 
  --
United States
Lead Inventor: 
Inventor IC: 
NCI
NCI
Inventor Lab URL: 
http://irp.nih.gov/pi/thomas-ried
LPM FIrst Name: 
Jaime
LPM Last Name: 
Greene
LPM Address: 
9609 Medical Center Drive, Room 1E-530 (MSC 9702)
LPM City: 
Rockville
Inv Is lead: 
LPM Zip: 
20850-9702
LPM State: 
MD
LPM Phone: 
240-276-6633
LPM Suffix: 
M.S.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
240-276-5504
DTDT Classification: 
Cancer
Diagnostics
In Vitro
Other
Therapeutics
Conventional Chemotherapy
Alkylating Agents
Alkaloids
DTDT Description: 
Cancer
Cancer - Diagnostics
Cancer - Diagnostics - In Vitro
Cancer - Diagnostics - In Vitro: Other
Cancer - Therapeutics
Cancer - Therapeutics - Conventional Chemotherapy
Cancer - Therapeutics - Conventional Chemotherapy: Alkylating Agents
Cancer - Therapeutics - Conventional Chemotherapy: Alkaloids
Pat Filing Date: 
2005-03-22
2006-03-22
2008-12-11
Patent Issue Date: 
2015-07-07
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/17030172
Publication Caption: 
PMID 17030172
Publication Title: 

Habermann JK, et al.

Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
E Number Only: 
E-106-2005
Inventor First Name: 
Thomas
Jens
Inventor Last Name: 
Ried
Habermann

Original Article: Identification of Colorectal Cancer Biomarkers by Serum Protein Profiling

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