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If cellular identity is to be maintained, it is important that actively transcribed chromatin stretches remain in a loose configuration as long as these genes are needed. Marc Bühler and his group have uncovered a novel positive feedback loop – crucially involving the histone acetyltransferase Mst2 – which ensures that (transcriptionally active) euchromatin cannot be easily converted into (inactive) heterochromatin. Because some of the players in this feedback loop have been implicated in cancer, these findings are relevant to our understanding of human diseases.
Original Article: Preserving the active chromatin stateNEXT ARTICLE
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...